MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.1.1.100	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3-oxoacyl-[acyl-carrier-protein] reductase
1.3.1.39	Oxidoreductases; Acting on the CH-CH group of donors; With NAD+ or NADP+ as acceptor; enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific)
2.3.1.38	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; [acyl-carrier-protein] S-acetyltransferase
2.3.1.39	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; [acyl-carrier-protein] S-malonyltransferase
2.3.1.41	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; β-ketoacyl-[acyl-carrier-protein] synthase I
2.3.1.85	Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; fatty-acid synthase system
3.1.2.14	Hydrolases; Acting on ester bonds; Thioester hydrolases; oleoyl-[acyl-carrier-protein] hydrolase
4.2.1.59	Lyases; Carbon-oxygen lyases; Hydro-lyases; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase

Structure

PDB	Resolution (Å)	PDB name
1XKT	2.6	Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain
2CG5	2.7	Structure of aminoadipate-semialdehyde dehydrogenase- phosphopantetheinyl transferase in complex with cytosolic acyl carrier protein and coenzyme A
2JFD	2.81	Structure of the MAT domain of human FAS
2JFK	2.4	Structure of the MAT domain of human FAS with malonyl-CoA
2PX6	2.3	Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat
3HHD	2.15	Structure of the Human Fatty Acid Synthase KS-MAT Didomain as a Framework for Inhibitor Design.
3TJM	1.48	Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct
4PIV	2.299	Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069
4W82	1.7	Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase
4W9N	1.84	Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase complexed with triclosan
4Z49	1.7	Homo Sapiens Fatty Acid Synthetase, Thioesterase Domain at 1.7 Angstroms Resolution
5C37	2.3	Structure of the beta-ketoacyl reductase domain of human fatty acid synthase bound to a spiro-imidazolone inhibitor
6NNA	2.26	Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and Compound 22
7MHD	2.03	Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
7MHE	2.8	Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7957

GO term

GO ontology	GO term	GO description
Biological Process	GO:0071353	cellular response to interleukin-4
Biological Process	GO:0090557	establishment of endothelial intestinal barrier
Biological Process	GO:0008611	ether lipid biosynthetic process
Biological Process	GO:0006633	fatty acid biosynthetic process
Biological Process	GO:0006631	fatty acid metabolic process
Biological Process	GO:0002068	glandular epithelial cell development
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0030879	mammary gland development
Biological Process	GO:0044788	modulation by host of viral process
Biological Process	GO:0030224	monocyte differentiation
Biological Process	GO:0030223	neutrophil differentiation
Biological Process	GO:0001649	osteoblast differentiation
Molecular Function	GO:0008693	(3R)-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity
Molecular Function	GO:0047451	(3R)-3-hydroxyoctanoyl-acyl-carrier-protein dehydratase activity
Molecular Function	GO:0047450	(3R)-hydroxybutanoyl-acyl-carrier-protein hydratase activity
Molecular Function	GO:0008659	(3R)-hydroxymyristoyl-acyl-carrier-protein dehydratase activity
Molecular Function	GO:0004317	(3R)-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity
Molecular Function	GO:0004316	3-oxoacyl-acyl-carrier-protein reductase (NADPH) activity
Molecular Function	GO:0004315	3-oxoacyl-acyl-carrier-protein synthase activity
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0004313	acyl-carrier-protein S-acetyltransferase activity
Molecular Function	GO:0004314	acyl-carrier-protein S-malonyltransferase activity
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0047117	enoyl-acyl-carrier-protein reductase (NADPH, A-specific) activity
Molecular Function	GO:0004312	fatty acid synthase activity
Molecular Function	GO:0016295	myristoyl-acyl-carrier-protein hydrolase activity
Molecular Function	GO:0016296	palmitoyl-acyl-carrier-protein hydrolase activity
Molecular Function	GO:0031177	phosphopantetheine binding
Cellular Component	GO:0005794	Golgi apparatus
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0042587	glycogen granule
Cellular Component	GO:0042470	melanosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005886	plasma membrane

InterPro / Pfam

InterPro	InterPro name
IPR001031	Thioesterase
IPR001227	Acyl transferase domain superfamily
IPR006162	Phosphopantetheine attachment site
IPR009081	Phosphopantetheine binding ACP domain
IPR011032	GroES-like superfamily
IPR013149	Alcohol dehydrogenase-like, C-terminal
IPR013217	Methyltransferase type 12
IPR013968	Polyketide synthase, ketoreductase domain
IPR014030	Beta-ketoacyl synthase, N-terminal
IPR014031	Beta-ketoacyl synthase, C-terminal
IPR014043	Acyl transferase
IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
IPR016036	Malonyl-CoA ACP transacylase, ACP-binding
IPR016039	Thiolase-like
IPR018201	Beta-ketoacyl synthase, active site
IPR020806	Polyketide synthase, phosphopantetheine-binding domain
IPR020807	Polyketide synthase, dehydratase domain
IPR020841	Polyketide synthase, beta-ketoacyl synthase domain
IPR020843	Polyketide synthase, enoylreductase domain
IPR029058	Alpha/Beta hydrolase fold
IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
IPR032821	Polyketide synthase, C-terminal extension
IPR036291	NAD(P)-binding domain superfamily
IPR036736	ACP-like superfamily
IPR042104	Polyketide synthase, dehydratase domain superfamily

Pfam	Pfam name
PF00107	Zinc-binding dehydrogenase
PF00109	Beta-ketoacyl synthase, N-terminal domain
PF00550	Phosphopantetheine attachment site
PF00698	Acyl transferase domain
PF00975	Thioesterase domain
PF02801	Beta-ketoacyl synthase, C-terminal domain
PF08242	Methyltransferase domain
PF08659	KR domain
PF14765	Polyketide synthase dehydratase
PF16197	Ketoacyl-synthetase C-terminal extension

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-163765	ChREBP activates metabolic gene expression	Leaf	R-HSA-1430728	Metabolism
R-HSA-199220	Vitamin B5 (pantothenate) metabolism	Internal node	R-HSA-1430728	Metabolism
R-HSA-2426168	Activation of gene expression by SREBF (SREBP)	Leaf	R-HSA-1430728	Metabolism
R-HSA-75105	Fatty acyl-CoA biosynthesis	Internal node	R-HSA-1430728	Metabolism
R-HSA-9029558	NR1H2 & NR1H3 regulate gene expression linked to lipogenesis	Leaf	R-HSA-162582	Signal Transduction

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:17081065
Melanosome	ECO:0000269	PubMed:17081065

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	High	Enhanced
breast	adipocytes	High	Enhanced
breast	glandular cells	High	Enhanced
cerebellum	molecular layer cells - cytoplasm/membrane	Medium	Enhanced

Summary of P49327

Gene: FASN, FAS
Protein: Fatty acid synthase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P49327

Gene: FASN, FAS Protein: Fatty acid synthase

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: FASN, FAS
Protein: Fatty acid synthase