Protein family
Protein sequence
Protein function
EC number | EC number description |
---|---|
1.1.1.100 | Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3-oxoacyl-[acyl-carrier-protein] reductase |
1.3.1.39 | Oxidoreductases; Acting on the CH-CH group of donors; With NAD+ or NADP+ as acceptor; enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific) |
2.3.1.38 | Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; [acyl-carrier-protein] S-acetyltransferase |
2.3.1.39 | Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; [acyl-carrier-protein] S-malonyltransferase |
2.3.1.41 | Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; β-ketoacyl-[acyl-carrier-protein] synthase I |
2.3.1.85 | Transferases; Acyltransferases; Transferring groups other than aminoacyl groups; fatty-acid synthase system |
3.1.2.14 | Hydrolases; Acting on ester bonds; Thioester hydrolases; oleoyl-[acyl-carrier-protein] hydrolase |
4.2.1.59 | Lyases; Carbon-oxygen lyases; Hydro-lyases; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase |
PDB | Resolution (Å) | PDB name |
---|---|---|
1XKT | 2.6 | Human fatty acid synthase: Structure and substrate selectivity of the thioesterase domain |
2CG5 | 2.7 | Structure of aminoadipate-semialdehyde dehydrogenase- phosphopantetheinyl transferase in complex with cytosolic acyl carrier protein and coenzyme A |
2JFD | 2.81 | Structure of the MAT domain of human FAS |
2JFK | 2.4 | Structure of the MAT domain of human FAS with malonyl-CoA |
2PX6 | 2.3 | Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat |
3HHD | 2.15 | Structure of the Human Fatty Acid Synthase KS-MAT Didomain as a Framework for Inhibitor Design. |
3TJM | 1.48 | Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct |
4PIV | 2.299 | Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and GSK2194069 |
4W82 | 1.7 | Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase |
4W9N | 1.84 | Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase complexed with triclosan |
GO ontology
| GO term | GO description |
---|---|---|
Biological Process | GO:0071353 | cellular response to interleukin-4 |
Biological Process | GO:0090557 | establishment of endothelial intestinal barrier |
Biological Process | GO:0008611 | ether lipid biosynthetic process |
Biological Process | GO:0006633 | fatty acid biosynthetic process |
Biological Process | GO:0006631 | fatty acid metabolic process |
Biological Process | GO:0002068 | glandular epithelial cell development |
Biological Process | GO:0006954 | inflammatory response |
Biological Process | GO:0030879 | mammary gland development |
Biological Process | GO:0044788 | modulation by host of viral process |
Biological Process | GO:0030224 | monocyte differentiation |
InterPro
| InterPro name |
---|---|
IPR001031 | Thioesterase |
IPR001227 | Acyl transferase domain superfamily |
IPR006162 | Phosphopantetheine attachment site |
IPR009081 | Phosphopantetheine binding ACP domain |
IPR011032 | GroES-like superfamily |
IPR013149 | Alcohol dehydrogenase-like, C-terminal |
IPR013217 | Methyltransferase type 12 |
IPR013968 | Polyketide synthase, ketoreductase domain |
IPR014030 | Beta-ketoacyl synthase, N-terminal |
IPR014031 | Beta-ketoacyl synthase, C-terminal |
Pfam
| Pfam name |
---|---|
PF00107 | Zinc-binding dehydrogenase |
PF00109 | Beta-ketoacyl synthase, N-terminal domain |
PF00550 | Phosphopantetheine attachment site |
PF00698 | Acyl transferase domain |
PF00975 | Thioesterase domain |
PF02801 | Beta-ketoacyl synthase, C-terminal domain |
PF08242 | Methyltransferase domain |
PF08659 | KR domain |
PF14765 | Polyketide synthase dehydratase |
PF16197 | Ketoacyl-synthetase C-terminal extension |
Reactome
| Reactome Name | Node type
| Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-163765 | ChREBP activates metabolic gene expression | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-199220 | Vitamin B5 (pantothenate) metabolism | Internal node | R-HSA-1430728 | Metabolism |
R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-75105 | Fatty acyl-CoA biosynthesis | Internal node | R-HSA-1430728 | Metabolism |
R-HSA-9029558 | NR1H2 & NR1H3 regulate gene expression linked to lipogenesis | Leaf | R-HSA-162582 | Signal Transduction |
Location
| ECO term
| Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:17081065 |
Melanosome | ECO:0000269 | PubMed:17081065 |