Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.5.1.58
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date);
protein farnesyltransferase
2.5.1.59
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date);
protein geranylgeranyltransferase type I
PDB | Resolution (Å) | PDB name |
---|---|---|
1JCQ | 2.3 | CRYSTAL STRUCTURE OF HUMAN PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH FARNESYL DIPHOSPHATE AND THE PEPTIDOMIMETIC INHIBITOR L-739,750 |
1LD7 | 2.0 | Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 66 |
1LD8 | 1.8 | Co-crystal structure of Human Farnesyltransferase with farnesyldiphosphate and inhibitor compound 49 |
1MZC | 2.0 | Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a |
1S63 | 1.9 | Human protein farnesyltransferase complexed with L-778,123 and FPP |
1SA4 | 2.1 | human protein farnesyltransferase complexed with FPP and R115777 |
1TN6 | 1.8 | Protein Farnesyltransferase Complexed with a Rap2a Peptide Substrate and a FPP Analog at 1.8A Resolution |
2F0Y | 2.7 | Crystal Structure Of Human Protein Farnesyltransferase Complexed With Farnesyl Diphosphate and hydantoin derivative |
2H6F | 1.5 | Protein Farnesyltransferase Complexed with a Farnesylated DDPTASACVLS Peptide Product at 1.5A Resolution |
2H6G | 1.85 | W102T Protein Farnesyltransferase Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 1.85A Resolution |
2H6H | 1.8 | Y365F Protein Farnesyltransferase Mutant Complexed with a Farnesylated DDPTASACVLS Peptide Product at 1.8A |
2H6I | 3.0 | W102T/Y365F Protein Farnesyltransferase Double Mutant Complexed with a Geranylgeranylated DDPTASACVLS Peptide Product at 3.0A |
2IEJ | 1.8 | Human Protein Farnesyltransferase Complexed with Inhibitor Compound STN-48 And FPP Analog at 1.8A Resolution |
3E37 | 1.8 | Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor 5 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0045213 | neurotransmitter receptor metabolic process |
Biological Process | GO:0090045 | positive regulation of deacetylase activity |
Biological Process | GO:0090044 | positive regulation of tubulin deacetylation |
Biological Process | GO:0018343 | protein farnesylation |
Biological Process | GO:0018344 | protein geranylgeranylation |
Biological Process | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering |
Biological Process | GO:0007179 | transforming growth factor beta receptor signaling pathway |
Molecular Function | GO:0004662 | CAAX-protein geranylgeranyltransferase activity |
Molecular Function | GO:0004663 | Rab geranylgeranyltransferase activity |
Molecular Function | GO:0030548 | acetylcholine receptor regulator activity |
Molecular Function | GO:0043014 | alpha-tubulin binding |
Molecular Function | GO:0008017 | microtubule binding |
Molecular Function | GO:0060090 | molecular adaptor activity |
Molecular Function | GO:0004660 | protein farnesyltransferase activity |
Molecular Function | GO:0004661 | protein geranylgeranyltransferase activity |
Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
Cellular Component | GO:0005953 | CAAX-protein geranylgeranyltransferase complex |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005875 | microtubule associated complex |
Cellular Component | GO:0005886 | plasma membrane |
Cellular Component | GO:0005965 | protein farnesyltransferase complex |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-111465 | Apoptotic cleavage of cellular proteins | Internal node | R-HSA-5357801 | Programmed Cell Death |
R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade | Leaf | R-HSA-9709957 | Sensory Perception |
R-HSA-9648002 | RAS processing | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-9679191 | Potential therapeutics for SARS | Leaf | R-HSA-1643685 | Disease |