MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2IV8	2.8	beta appendage in complex with b-arrestin peptide
6PWC	4.9	A complex structure of arrestin-2 bound to neurotensin receptor 1
6TKO	3.3	Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc.
6UP7	4.2	neurotensin receptor and arrestin2 complex
7R0C	4.73	Structure of the AVP-V2R-arrestin2-ScFv30 complex
7R0J	4.23	Structure of the V2 receptor Cter-arrestin2-ScFv30 complex
7SRS	3.3	5-HT2B receptor bound to LSD in complex with beta-arrestin1 obtained by cryo-electron microscopy (cryoEM)

GO term

GO ontology	GO term	GO description
Biological Process	GO:0002031	G protein-coupled receptor internalization
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity
Biological Process	GO:0045746	negative regulation of Notch signaling pathway
Biological Process	GO:0032715	negative regulation of interleukin-6 production
Biological Process	GO:0032717	negative regulation of interleukin-8 production
Biological Process	GO:0031397	negative regulation of protein ubiquitination
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade
Biological Process	GO:0035025	positive regulation of Rho protein signal transduction
Biological Process	GO:0035066	positive regulation of histone acetylation
Biological Process	GO:0001934	positive regulation of protein phosphorylation
Biological Process	GO:0002092	positive regulation of receptor internalization
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0015031	protein transport
Biological Process	GO:0016567	protein ubiquitination
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0043149	stress fiber assembly
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process
Biological Process	GO:0007601	visual perception
Molecular Function	GO:0001664	G protein-coupled receptor binding
Molecular Function	GO:0005096	GTPase activator activity
Molecular Function	GO:0031701	angiotensin receptor binding
Molecular Function	GO:1990763	arrestin family protein binding
Molecular Function	GO:0004857	enzyme inhibitor activity
Molecular Function	GO:0005159	insulin-like growth factor receptor binding
Molecular Function	GO:0003713	transcription coactivator activity
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Cellular Component	GO:0000139	Golgi membrane
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005905	clathrin-coated pit
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0031410	cytoplasmic vesicle
Cellular Component	GO:0030659	cytoplasmic vesicle membrane
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005765	lysosomal membrane
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0031143	pseudopodium

InterPro / Pfam

InterPro	InterPro name
IPR000698	Arrestin
IPR011021	Arrestin-like, N-terminal
IPR011022	Arrestin C-terminal-like domain
IPR014752	Arrestin-like, C-terminal
IPR014753	Arrestin, N-terminal
IPR014756	Immunoglobulin E-set
IPR017864	Arrestin, conserved site

Pfam	Pfam name
PF00339	Arrestin (or S-antigen), N-terminal domain
PF02752	Arrestin (or S-antigen), C-terminal domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	Leaf	R-HSA-162582	Signal Transduction
R-HSA-418555	G alpha (s) signalling events	Internal node	R-HSA-162582	Signal Transduction
R-HSA-432720	Lysosome Vesicle Biogenesis	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-432722	Golgi Associated Vesicle Biogenesis	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-456926	Thrombin signalling through proteinase activated receptors (PARs)	Leaf	R-HSA-109582	Hemostasis
R-HSA-5635838	Activation of SMO	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5674135	MAP2K and MAPK activation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5689880	Ub-specific processing proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-6802946	Signaling by moderate kinase activity BRAF mutants	Leaf	R-HSA-1643685	Disease
R-HSA-6802948	Signaling by high-kinase activity BRAF mutants	Leaf	R-HSA-1643685	Disease
R-HSA-6802952	Signaling by BRAF and RAF1 fusions	Leaf	R-HSA-1643685	Disease
R-HSA-6802955	Paradoxical activation of RAF signaling by kinase inactive BRAF	Leaf	R-HSA-1643685	Disease
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-8856828	Clathrin-mediated endocytosis	Internal node	R-HSA-5653656	Vesicle-mediated transport
R-HSA-9649948	Signaling downstream of RAS mutants	Leaf	R-HSA-1643685	Disease
R-HSA-9656223	Signaling by RAF1 mutants	Leaf	R-HSA-1643685	Disease

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	Medium	Approved
breast	glandular cells	Medium	Approved
bronchus	basal cells	Low	Approved
bronchus	ciliated cells (cell body)	Medium	Approved
bronchus	goblet cells	Medium	Approved
caudate	neuronal cells	Medium	Approved
cerebellum	Purkinje cells	High	Approved
cerebral cortex	neuronal cells	Medium	Approved
cervix	glandular cells	Medium	Approved
cervix	squamous epithelial cells	Medium	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	glandular cells	Low	Approved
endometrium 2	glandular cells	Low	Approved
epididymis	glandular cells	Low	Approved
esophagus	squamous epithelial cells	Low	Approved
fallopian tube	ciliated cells (cell body)	Low	Approved
fallopian tube	ciliated cells (ciliary rootlets)	Low	Approved
fallopian tube	ciliated cells (tip of cilia)	Low	Approved
fallopian tube	non-ciliated cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
hippocampus	neuronal cells	Low	Approved
kidney	cells in glomeruli	Medium	Approved
kidney	cells in tubules	Low	Approved
liver	cholangiocytes	Low	Approved
liver	hepatocytes	Low	Approved
lung	alveolar cells	Medium	Approved
lung	macrophages	Medium	Approved
nasopharynx	basal cells	Medium	Approved
nasopharynx	ciliated cells (cell body)	Medium	Approved
nasopharynx	goblet cells	High	Approved
oral mucosa	squamous epithelial cells	Low	Approved
ovary	follicle cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
pancreas	pancreatic endocrine cells	Low	Approved
placenta	decidual cells	Medium	Approved
placenta	trophoblastic cells	Low	Approved
rectum	glandular cells	Medium	Approved
skin 1	fibroblasts	Medium	Approved
skin 1	keratinocytes	Medium	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	Medium	Approved
smooth muscle	smooth muscle cells	Low	Approved
soft tissue 1	fibroblasts	Medium	Approved
soft tissue 2	fibroblasts	High	Approved
stomach 2	glandular cells	Low	Approved
testis	Leydig cells	Medium	Approved
testis	spermatogonia cells	Low	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	Low	Approved
urinary bladder	urothelial cells	Low	Approved
vagina	squamous epithelial cells	Low	Approved

Disease

Location	ECO term	Pubmed
Cell membrane
Cell projection, pseudopodium	ECO:0000250
Cytoplasm
Cytoplasmic vesicle
Membrane, clathrin-coated pit	ECO:0000305
Nucleus

Summary of P49407

Gene: ARRB1, ARR1
Protein: Beta-arrestin-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P49407

Gene: ARRB1, ARR1 Protein: Beta-arrestin-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: ARRB1, ARR1
Protein: Beta-arrestin-1