Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.7.51
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases;
adenylylsulfate—ammonia adenylyltransferase
3.6.1.29
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides;
bis(5′-adenosyl)-triphosphatase
3.6.2.1
Hydrolases;
Acting on acid anhydrides;
In sulfonyl-containing anhydrides;
adenylylsulfatase
3.9.1.-
Hydrolases;
Acting on phosphorus-nitrogen bonds;
Acting on phosphorus-nitrogen bonds (only sub-subclass identified to date);
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1FHI | 3.1 | SUBSTRATE ANALOG (IB2) COMPLEX WITH THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT |
| 1FIT | 1.85 | FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) |
| 2FHI | 2.6 | SUBSTRATE ANALOG (IB2) COMPLEX WITH THE HIS 96 ASN SUBSTITUTION OF THE FRAGILE HISTIDINE TRIAD PROTEIN, FHIT |
| 2FIT | 1.9 | FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) |
| 3FIT | 2.4 | FHIT (FRAGILE HISTIDINE TRIAD PROTEIN) IN COMPLEX WITH ADENOSINE/SULFATE AMP ANALOG |
| 4FIT | 2.5 | FHIT-APO |
| 5FIT | 2.3 | FHIT-SUBSTRATE ANALOG |
| 6FIT | 2.6 | FHIT-TRANSITION STATE ANALOG |
| 7P8P | 2.34 | Crystal structure of Fhit covalently bound to a nucleotide |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0015964 | diadenosine triphosphate catabolic process |
| Biological Process | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator |
| Biological Process | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0006163 | purine nucleotide metabolic process |
| Molecular Function | GO:0043530 | adenosine 5'-monophosphoramidase activity |
| Molecular Function | GO:0047627 | adenylylsulfatase activity |
| Molecular Function | GO:0047352 | adenylylsulfate-ammonia adenylyltransferase activity |
| Molecular Function | GO:0047710 | bis(5'-adenosyl)-triphosphatase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001650 | fibrillar center |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:15007172 |
| Cytoplasm | ECO:0000269 | PubMed:15313915 |
| Mitochondrion | ECO:0000269 | PubMed:19622739 |
| Nucleus | ECO:0000269 | PubMed:15313915 |