Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2EBQ | Solution structure of the second zf-RanBP domain from human Nuclear pore complex protein Nup153 | |
| 2EBR | Solution structure of the fourth zf-RanBP domain from human Nuclear pore complex protein Nup153 | |
| 2EBV | Solution structure of the third zf-RanBP domain from human Nuclear pore complex protein Nup153 | |
| 2GQE | Molecular characterization of the Ran binding zinc finger domain | |
| 4U0C | 1.77 | Hexameric HIV-1 CA in complex with Nup153 peptide, P6 crystal form |
| 4U0D | 3.0 | Hexameric HIV-1 CA in complex with Nup153 peptide, P212121 crystal form |
| 5TSV | 2.502 | HIV-1 CA hexamer with NUP153 peptide - R3 crystal form |
| 5TSX | 1.899 | HIV-1 CA hexamer with NUP153 peptide - P1 crystal form |
| 6AYA | 2.4 | Structure of the native full-length HIV-1 capsid protein in complex with Nup153 peptide |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006405 | RNA export from nucleus |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:0046832 | negative regulation of RNA export from nucleus |
| Biological Process | GO:0051292 | nuclear pore complex assembly |
| Biological Process | GO:0006913 | nucleocytoplasmic transport |
| Biological Process | GO:0006606 | protein import into nucleus |
| Biological Process | GO:0046718 | viral entry into host cell |
| Biological Process | GO:0075732 | viral penetration into host nucleus |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0008139 | nuclear localization sequence binding |
| Molecular Function | GO:0043495 | protein-membrane adaptor activity |
| Molecular Function | GO:0017056 | structural constituent of nuclear pore |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043657 | host cell |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0042405 | nuclear inclusion body |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0034399 | nuclear periphery |
| Cellular Component | GO:0005643 | nuclear pore |
| Cellular Component | GO:0044615 | nuclear pore nuclear basket |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| InterPro
|
InterPro name |
|---|---|
| IPR001876 | Zinc finger, RanBP2-type |
| IPR013913 | Nucleoporin Nup153, N-terminal |
| IPR018892 | Retro-transposon transporting motif |
| IPR026054 | Nuclear pore complex protein |
| IPR036443 | Zinc finger, RanBP2-type superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00641 | Zn-finger in Ran binding protein and others |
| PF08604 | Nucleoporin Nup153-like |
| PF10599 | Retro-transposon transporting motif |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1169408 | ISG15 antiviral mechanism | Leaf | R-HSA-168256 | Immune System |
| R-HSA-159227 | Transport of the SLBP independent Mature mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | Leaf | R-HSA-1643685 | Disease |
| R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | Leaf | R-HSA-1643685 | Disease |
| R-HSA-168276 | NS1 Mediated Effects on Host Pathways | Internal node | R-HSA-1643685 | Disease |
| R-HSA-168325 | Viral Messenger RNA Synthesis | Leaf | R-HSA-1643685 | Disease |
| R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | Leaf | R-HSA-1643685 | Disease |
| R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-180746 | Nuclear import of Rev protein | Leaf | R-HSA-1643685 | Disease |
| R-HSA-180910 | Vpr-mediated nuclear import of PICs | Leaf | R-HSA-1643685 | Disease |
| R-HSA-191859 | snRNP Assembly | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-3232142 | SUMOylation of ubiquitinylation proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-4085377 | SUMOylation of SUMOylation proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-4551638 | SUMOylation of chromatin organization proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-4570464 | SUMOylation of RNA binding proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-4615885 | SUMOylation of DNA replication proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-5578749 | Transcriptional regulation by small RNAs | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | Leaf | R-HSA-1643685 | Disease |
| R-HSA-6784531 | tRNA processing in the nucleus | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-9609690 | HCMV Early Events | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9610379 | HCMV Late Events | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | Leaf | R-HSA-1643685 | Disease |