Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.3.2.-
Transferases;
Acyltransferases;
Aminoacyltransferases;
PDB | Resolution (Å) | PDB name |
---|---|---|
1RRP | 2.96 | STRUCTURE OF THE RAN-GPPNHP-RANBD1 COMPLEX |
1XKE | Solution structure of the second Ran-binding domain from human RanBP2 | |
1Z5S | 3.01 | Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2 |
2LAS | Molecular Determinants of Paralogue-Specific SUMO-SIM Recognition | |
3UIN | 2.597 | Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 |
3UIO | 2.602 | Complex between human RanGAP1-SUMO2, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II |
3UIP | 2.293 | Complex between human RanGAP1-SUMO1, UBC9 and the IR1 domain from RanBP2 containing IR2 Motif II |
4GA0 | 1.15 | Structure of the N-terminal domain of Nup358 |
4I9Y | 1.75 | Structure of the C-terminal domain of Nup358 |
4L6E | 2.496 | Crystal Structure of the RanBD1 fourth domain of E3 SUMO-protein ligase RanBP2. Northeast Structural Genomics Consortium (NESG) Target HR9193b |
4LQW | 1.95 | Crystal structure of HIV-1 capsid N-terminal domain in complex with NUP358 cyclophilin |
5CLL | 2.45 | Truncated Ran wild type in complex with GDP-BeF and RanBD1 |
5CLQ | 3.2 | Ran Y39A in complex with GPPNHP and RanBD1 |
7MNJ | 3.8 | Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 145-673) |
7MNK | 1.1 | Crystal structure of the tetramerization element of NUP358/RanBP2 (residues 805-832) |
7MNL | 3.95 | Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) in complex with Fab fragment |
7MNM | 4.7 | Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T585M mutant in complex with Fab fragment |
7MNN | 6.7 | Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) T653I mutant in complex with Fab fragment |
7MNO | 6.73 | Crystal structure of the N-terminal domain of NUP358/RanBP2 (residues 1-752) I656V mutant in complex with Fab fragment |
7MNP | 2.05 | Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP |
7MNQ | 2.05 | Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP |
7MNR | 1.8 | Crystal Structure of the ZnF3 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP |
7MNS | 2.1 | Crystal Structure of the ZnF4 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP |
7MNT | 2.45 | Crystal Structure of the ZnF5 or ZnF6 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP |
7MNU | 2.0 | Crystal Structure of the ZnF7 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP |
7MNV | 1.8 | Crystal Structure of the ZnF8 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP |
7MNW | 2.4 | Crystal Structure of Nup358/RanBP2 Ran-binding domain 1 in complex with Ran-GPPNHP |
7MNX | 2.4 | Crystal Structure of Nup358/RanBP2 Ran-binding domain 2 in complex with Ran-GPPNHP |
7MNY | 2.7 | Crystal Structure of Nup358/RanBP2 Ran-binding domain 3 in complex with Ran-GPPNHP |
7MNZ | 2.35 | Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP |
7R5J | 50.0 | Human nuclear pore complex (dilated) |
7R5K | 12.0 | Human nuclear pore complex (constricted) |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006607 | NLS-bearing protein import into nucleus |
Biological Process | GO:0051642 | centrosome localization |
Biological Process | GO:0051028 | mRNA transport |
Biological Process | GO:0051168 | nuclear export |
Biological Process | GO:0006913 | nucleocytoplasmic transport |
Biological Process | GO:0033133 | positive regulation of glucokinase activity |
Biological Process | GO:0006457 | protein folding |
Biological Process | GO:0000413 | protein peptidyl-prolyl isomerization |
Biological Process | GO:0016925 | protein sumoylation |
Biological Process | GO:0006111 | regulation of gluconeogenesis |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0061665 | SUMO ligase activity |
Molecular Function | GO:0019789 | SUMO transferase activity |
Molecular Function | GO:0046872 | metal ion binding |
Molecular Function | GO:0031267 | small GTPase binding |
Cellular Component | GO:0106068 | SUMO ligase complex |
Cellular Component | GO:0005642 | annulate lamellae |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005635 | nuclear envelope |
Cellular Component | GO:0042405 | nuclear inclusion body |
Cellular Component | GO:0031965 | nuclear membrane |
Cellular Component | GO:0005643 | nuclear pore |
Cellular Component | GO:0044614 | nuclear pore cytoplasmic filaments |
Cellular Component | GO:0044615 | nuclear pore nuclear basket |
Cellular Component | GO:0005654 | nucleoplasm |
InterPro | InterPro name |
---|---|
IPR000156 | Ran binding domain |
IPR001876 | Zinc finger, RanBP2-type |
IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
IPR011990 | Tetratricopeptide-like helical domain superfamily |
IPR011993 | PH-like domain superfamily |
IPR019734 | Tetratricopeptide repeat |
IPR020892 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site |
IPR022011 | Nup358/RanBP2 E3 ligase domain |
IPR029000 | Cyclophilin-like domain superfamily |
IPR036443 | Zinc finger, RanBP2-type superfamily |
IPR045255 | Ran binding protein RanBP1-like |
Pfam | Pfam name |
---|---|
PF00160 | Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD |
PF00638 | RanBP1 domain |
PF00641 | Zn-finger in Ran binding protein and others |
PF12185 | Nup358/RanBP2 E3 ligase domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-1169408 | ISG15 antiviral mechanism | Leaf | R-HSA-168256 | Immune System |
R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | Leaf | R-HSA-1640170 | Cell Cycle |
R-HSA-159227 | Transport of the SLBP independent Mature mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-165054 | Rev-mediated nuclear export of HIV RNA | Leaf | R-HSA-1643685 | Disease |
R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus | Leaf | R-HSA-1643685 | Disease |
R-HSA-168276 | NS1 Mediated Effects on Host Pathways | Internal node | R-HSA-1643685 | Disease |
R-HSA-168325 | Viral Messenger RNA Synthesis | Leaf | R-HSA-1643685 | Disease |
R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery | Leaf | R-HSA-1643685 | Disease |
R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-180746 | Nuclear import of Rev protein | Leaf | R-HSA-1643685 | Disease |
R-HSA-180910 | Vpr-mediated nuclear import of PICs | Leaf | R-HSA-1643685 | Disease |
R-HSA-191859 | snRNP Assembly | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-2467813 | Separation of Sister Chromatids | Leaf | R-HSA-1640170 | Cell Cycle |
R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | Leaf | R-HSA-1640170 | Cell Cycle |
R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-3232142 | SUMOylation of ubiquitinylation proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | Leaf | R-HSA-1640170 | Cell Cycle |
R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
R-HSA-4085377 | SUMOylation of SUMOylation proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-4551638 | SUMOylation of chromatin organization proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-4570464 | SUMOylation of RNA binding proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-4615885 | SUMOylation of DNA replication proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-5578749 | Transcriptional regulation by small RNAs | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-5619107 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) | Leaf | R-HSA-1643685 | Disease |
R-HSA-5663220 | RHO GTPases Activate Formins | Leaf | R-HSA-162582 | Signal Transduction |
R-HSA-6784531 | tRNA processing in the nucleus | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-68877 | Mitotic Prometaphase | Internal node | R-HSA-1640170 | Cell Cycle |
R-HSA-9609690 | HCMV Early Events | Leaf | R-HSA-1643685 | Disease |
R-HSA-9610379 | HCMV Late Events | Leaf | R-HSA-1643685 | Disease |
R-HSA-9648025 | EML4 and NUDC in mitotic spindle formation | Leaf | R-HSA-1640170 | Cell Cycle |
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | Leaf | R-HSA-1643685 | Disease |
R-HSA-9725370 | Signaling by ALK fusions and activated point mutants | Internal node | R-HSA-1643685 | Disease |
Location | ECO term | Pubmed |
---|---|---|
Nucleus | ECO:0000269 | PubMed:7775481 |
Nucleus envelope | ECO:0000269 | PubMed:20386726 |
Nucleus membrane | ECO:0000269 | PubMed:11839768 |
Nucleus, nuclear pore complex | ECO:0000269 | PubMed:11839768 |
Nucleus, nuclear pore complex | ECO:0000269 | PubMed:20386726 |
Nucleus, nuclear pore complex | ECO:0000269 | PubMed:23353830 |
Nucleus, nuclear pore complex | ECO:0000269 | PubMed:7603572 |
HPO ID | HPO name |
---|---|
HP:0000006 | Autosomal dominant inheritance |
HP:0001249 | Intellectual disability |
HP:0001250 | Seizure |
HP:0001257 | Spasticity |
HP:0001259 | Coma |
HP:0001260 | Dysarthria |
HP:0001276 | Hypertonia |
HP:0001288 | Gait disturbance |
HP:0001298 | Encephalopathy |
HP:0001945 | Fever |
HP:0002013 | Vomiting |
HP:0002063 | Rigidity |
HP:0002090 | Pneumonia |
HP:0002171 | Gliosis |
HP:0002181 | Cerebral edema |
HP:0002363 | Abnormal brainstem morphology |
HP:0002376 | Developmental regression |
HP:0002445 | Tetraplegia |
HP:0002510 | Spastic tetraplegia |
HP:0002715 | Abnormality of the immune system |
HP:0002793 | Abnormal pattern of respiration |
HP:0002922 | Increased CSF protein concentration |
HP:0003324 | Generalized muscle weakness |
HP:0003593 | Infantile onset |
HP:0003829 | Typified by incomplete penetrance |
HP:0006846 | Acute encephalopathy |
HP:0010663 | Abnormality of thalamus morphology |
HP:0011887 | Choroid hemorrhage |
HP:0012747 | Abnormal brainstem MRI signal intensity |
HP:0025404 | Abnormal visual fixation |
HP:0031982 | Abnormal putamen morphology |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
familial acute necrotizing encephalopathy | MONDO:0011953 | G93 | chapter6, Diseases of the nervous system | OMIM:608033 | Orphanet:88619 |