Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
2.7.11.26
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
tau-protein kinase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0016055 | Wnt signaling pathway |
| Biological Process | GO:0007568 | aging |
| Biological Process | GO:0003214 | cardiac left ventricle morphogenesis |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0071385 | cellular response to glucocorticoid stimulus |
| Biological Process | GO:0032869 | cellular response to insulin stimulus |
| Biological Process | GO:0036016 | cellular response to interleukin-3 |
| Biological Process | GO:0071285 | cellular response to lithium ion |
| Biological Process | GO:0007212 | dopamine receptor signaling pathway |
| Biological Process | GO:0060079 | excitatory postsynaptic potential |
| Biological Process | GO:0097191 | extrinsic apoptotic signaling pathway |
| Biological Process | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| Biological Process | GO:0005977 | glycogen metabolic process |
| Biological Process | GO:0008286 | insulin receptor signaling pathway |
| Biological Process | GO:0032007 | negative regulation of TOR signaling |
| Biological Process | GO:0010905 | negative regulation of UDP-glucose catabolic process |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development |
| Biological Process | GO:2000171 | negative regulation of dendrite development |
| Biological Process | GO:0044027 | negative regulation of gene expression via CpG island methylation |
| Biological Process | GO:0046325 | negative regulation of glucose import |
| Biological Process | GO:2000466 | negative regulation of glycogen (starch) synthase activity |
| Biological Process | GO:0045719 | negative regulation of glycogen biosynthetic process |
| Biological Process | GO:1904227 | negative regulation of glycogen synthase activity, transferring glucose-1-phosphate |
| Biological Process | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| Biological Process | GO:2000077 | negative regulation of type B pancreatic cell development |
| Biological Process | GO:0007399 | nervous system development |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:0018107 | peptidyl-threonine phosphorylation |
| Biological Process | GO:0106071 | positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0071879 | positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway |
| Biological Process | GO:1902004 | positive regulation of amyloid-beta formation |
| Biological Process | GO:0010508 | positive regulation of autophagy |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:2000467 | positive regulation of glycogen (starch) synthase activity |
| Biological Process | GO:0045823 | positive regulation of heart contraction |
| Biological Process | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| Biological Process | GO:0043525 | positive regulation of neuron apoptotic process |
| Biological Process | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| Biological Process | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| Biological Process | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0045732 | positive regulation of protein catabolic process |
| Biological Process | GO:1903955 | positive regulation of protein targeting to mitochondrion |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:1903146 | regulation of autophagy of mitochondrion |
| Biological Process | GO:0006349 | regulation of gene expression by genomic imprinting |
| Biological Process | GO:0010975 | regulation of neuron projection development |
| Biological Process | GO:0003073 | regulation of systemic arterial blood pressure |
| Biological Process | GO:0019082 | viral protein processing |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0120283 | protein serine/threonine kinase binding |
| Molecular Function | GO:0005102 | signaling receptor binding |
| Molecular Function | GO:0048156 | tau protein binding |
| Molecular Function | GO:0050321 | tau-protein kinase activity |
| Cellular Component | GO:0097440 | apical dendrite |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0030877 | beta-catenin destruction complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:1990635 | proximal dendrite |
| InterPro
|
InterPro name |
|---|---|
| IPR000719 | Protein kinase domain |
| IPR008271 | Serine/threonine-protein kinase, active site |
| IPR011009 | Protein kinase-like domain superfamily |
| IPR017441 | Protein kinase, ATP binding site |
| IPR039192 | Glycogen synthase kinase 3, catalytic domain |
| Pfam
|
Pfam name |
|---|---|
| PF00069 | Protein kinase domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-198323 | AKT phosphorylates targets in the cytosol | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-381038 | XBP1(S) activates chaperone genes | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9635465 | Suppression of apoptosis | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9683610 | Maturation of nucleoprotein | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9694631 | Maturation of nucleoprotein | Leaf | R-HSA-1643685 | Disease |
| Location
|
ECO term
|
Pubmed |
|---|
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | High | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | Purkinje cells | High | Approved |
| cerebellum | cells in granular layer | High | Approved |
| cerebellum | cells in molecular layer | High | Approved |
| cerebral cortex | endothelial cells | Medium | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cerebral cortex | neuropil | High | Approved |
| cervix | glandular cells | High | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | High | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | High | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | Low | Approved |
| esophagus | squamous epithelial cells | High | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | glial cells | Low | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | Medium | Approved |
| lung | alveolar cells | Medium | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | High | Approved |
| lymph node | non-germinal center cells | High | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | High | Approved |
| pancreas | pancreatic endocrine cells | High | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skeletal muscle | myocytes | Low | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| soft tissue 1 | peripheral nerve | Medium | Approved |
| soft tissue 2 | fibroblasts | Low | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | High | Approved |
| spleen | cells in white pulp | High | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | High | Approved |
| tonsil | germinal center cells | High | Approved |
| tonsil | non-germinal center cells | High | Approved |
| tonsil | squamous epithelial cells | High | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|