| 1GNG |
2.6 |
Glycogen synthase kinase-3 beta (GSK3) complex with FRATtide peptide |
| 1H8F |
2.8 |
Glycogen Synthase Kinase 3 beta. |
| 1I09 |
2.7 |
STRUCTURE OF GLYCOGEN SYNTHASE KINASE-3 (GSK3B) |
| 1J1B |
1.8 |
Binary complex structure of human tau protein kinase I with AMPPNP |
| 1J1C |
2.1 |
Binary complex structure of human tau protein kinase I with ADP |
| 1O6K |
1.7 |
Structure of activated form of PKB kinase domain S474D with GSK3 peptide and AMP-PNP |
| 1O6L |
1.6 |
Crystal structure of an activated Akt/protein kinase B (PKB-PIF chimera) ternary complex with AMP-PNP and GSK3 peptide |
| 1O9U |
2.4 |
GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH AXIN PEPTIDE |
| 1PYX |
2.4 |
GSK-3 Beta complexed with AMP-PNP |
| 1Q3D |
2.2 |
GSK-3 Beta complexed with Staurosporine |
| 1Q3W |
2.3 |
GSK-3 Beta complexed with Alsterpaullone |
| 1Q41 |
2.1 |
GSK-3 Beta complexed with Indirubin-3'-monoxime |
| 1Q4L |
2.77 |
GSK-3 Beta complexed with Inhibitor I-5 |
| 1Q5K |
1.94 |
crystal structure of Glycogen synthase kinase 3 in complexed with inhibitor |
| 1R0E |
2.25 |
Glycogen synthase kinase-3 beta in complex with 3-indolyl-4-arylmaleimide inhibitor |
| 1UV5 |
2.8 |
GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 6-BROMOINDIRUBIN-3'-OXIME |
| 2JDO |
1.8 |
STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL)AMIDE |
| 2JDR |
2.3 |
STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-443654 |
| 2JLD |
2.35 |
Extremely Tight Binding of Ruthenium Complex to Glycogen Synthase Kinase 3 |
| 2O5K |
3.2 |
Crystal Structure of GSK3beta in complex with a benzoimidazol inhibitor |
| 2OW3 |
2.8 |
Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor |
| 2UW9 |
2.1 |
STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piperidine |
| 2X39 |
1.93 |
Structure of 4-Amino-N-(4-chlorobenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin- 4-yl)piperidine-4-carboxamide bound to PKB |
| 2XH5 |
2.72 |
Structure of 4-(4-tert-Butylbenzyl)-1-(7H-pyrrolo(2,3-d)pyrimidin-4- yl)piperidin-4-amine bound to PKB |
| 3CQU |
2.2 |
Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor |
| 3CQW |
2.0 |
Crystal Structure of Akt-1 complexed with substrate peptide and inhibitor |
| 3DU8 |
2.2 |
Crystal structure of GSK-3 beta in complex with NMS-869553A |
| 3E87 |
2.3 |
Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors |
| 3E88 |
2.5 |
Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors |
| 3E8D |
2.7 |
Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors |
| 3F7Z |
2.4 |
X-ray Co-Crystal Structure of Glycogen Synthase Kinase 3beta in Complex with an Inhibitor |
| 3F88 |
2.6 |
glycogen synthase Kinase 3beta inhibitor complex |
| 3GB2 |
2.4 |
GSK3beta inhibitor complex |
| 3I4B |
2.3 |
Crystal structure of GSK3b in complex with a pyrimidylpyrrole inhibitor |
| 3L1S |
2.9 |
3-Aryl-4-(arylhydrazono)-1H-pyrazol-5-ones: Highly ligand efficient and potent inhibitors of GSK3 |
| 3M1S |
3.134 |
Structure of Ruthenium Half-Sandwich Complex Bound to Glycogen Synthase Kinase 3 |
| 3MV5 |
2.47 |
Crystal structure of Akt-1-inhibitor complexes |
| 3OW4 |
2.6 |
Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors |
| 3PUP |
2.99 |
Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1) |
| 3Q3B |
2.7 |
6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors |
| 3QKK |
2.3 |
Spirochromane Akt Inhibitors |
| 3SAY |
2.231 |
Crystal structure of human glycogen synthase kinase 3 beta (GSK3b) in complex with inhibitor 142 |
| 3SD0 |
2.7 |
Identification of a Glycogen Synthase Kinase-3b Inhibitor that Attenuates Hyperactivity in CLOCK Mutant Mice |
| 3ZDI |
2.645 |
Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d |
| 3ZRK |
2.37 |
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors |
| 3ZRL |
2.48 |
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors |
| 3ZRM |
2.49 |
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors |
| 4ACC |
2.21 |
GSK3b in complex with inhibitor |
| 4ACD |
2.6 |
GSK3b in complex with inhibitor |
| 4ACG |
2.6 |
GSK3b in complex with inhibitor |
| 4ACH |
2.6 |
GSK3b in complex with inhibitor |
| 4AFJ |
1.98 |
5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors |
| 4B7T |
2.772 |
Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Leucettine L4 |
| 4DIT |
2.6 |
Crystal Structure of GSK3beta in complex with a Imidazopyridine inhibitor |
| 4EKK |
2.8 |
Akt1 with AMP-PNP |
| 4IQ6 |
3.12 |
Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine |
| 4J1R |
2.702 |
Crystal Structure of GSK3b in complex with inhibitor 15R |
| 4J71 |
2.31 |
Crystal Structure of GSK3b in complex with inhibitor 1R |
| 4NM0 |
2.5 |
Crystal structure of peptide inhibitor-free GSK-3/Axin complex |
| 4NM3 |
2.1 |
Crystal structure of GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide |
| 4NM5 |
2.3 |
Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 c-motif |
| 4NM7 |
2.3 |
Crystal structure of GSK-3/Axin complex bound to phosphorylated Wnt receptor LRP6 e-motif |
| 4PTC |
2.711 |
Structure of a carboxamide compound (3) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-OXO-4H-1LAMBDA~4~,3-THIAZOLE-5-CARBOXAMIDE) to GSK3b |
| 4PTE |
2.033 |
Structure of a carvoxamide compound (15) (N-[4-(ISOQUINOLIN-7-YL)PYRIDIN-2-YL]CYCLOPROPANECARBOXAMIDE) to GSK3b |
| 4PTG |
2.361 |
Structure of a carboxamine compound (26) (2-{2-[(CYCLOPROPYLCARBONYL)AMINO]PYRIDIN-4-YL}-4-METHOXYPYRIMIDINE-5-CARBOXAMIDE) to GSK3b |
| 5F94 |
2.51 |
Crystal structure of GSK3b in complex with Compound 15: 2-[(cyclopropylcarbonyl)amino]-N-(4-methoxypyridin-3-yl)pyridine-4-carboxamide |
| 5F95 |
2.525 |
Crystal structure of GSK3b in complex with Compound 18: 2-[(cyclopropylcarbonyl)amino]-N-(4-phenylpyridin-3-yl)pyridine-4-carboxamide |
| 5HLN |
3.1 |
X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH CHIR99021 |
| 5HLP |
2.45 |
X-RAY CRYSTAL STRUCTURE OF GSK3B IN COMPLEX WITH BRD3937 |
| 5K5N |
2.2 |
Crystal structure of GSK-3beta complexed with PF-04802367, a highly selective brain-penetrant kinase inhibitor |
| 5KPK |
2.4 |
Glycogen Synthase Kinase 3 beta Complexed with BRD0209 |
| 5KPL |
2.6 |
Glycogen Synthase Kinase 3 beta Complexed with BRD0705 |
| 5KPM |
2.69 |
Glycogen Synthase Kinase 3 beta Complexed with BRD3731 |
| 5OY4 |
3.2 |
GSK3beta complex with N-(6-(3,4-dihydroxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide |
| 5T31 |
2.85 |
Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia |
| 6B8J |
2.595 |
Co-structure of human glycogen synthase kinase beta with a selective (5-imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine inhibitor |
| 6BUU |
2.4 |
Crystal structure of AKT1 (aa 144-480) with a bisubstrate |
| 6GJO |
2.91 |
Crystal Structure of Glycogen Synthase Kinase-3 beta in Complex with BI-91BS |
| 6GN1 |
2.6 |
Crystal Structure of Glycogen synthase kinase-3 beta (GSK3B) in Complex with PIK-75 |
| 6H0U |
2.3 |
Glycogen synthase kinase-3 beta (GSK3) complex with a covalent [1,2,4]triazolo[1,5-a][1,3,5]triazine inhibitor |
| 6HK3 |
2.35 |
Crystal structure of GSK-3B in complex with pyrazine inhibitor C44 |
| 6HK4 |
2.5 |
Crystal structure of GSK-3B in complex with pyrazine inhibitor C22 |
| 6HK7 |
3.2 |
Crystal structure of GSK-3B in complex with pyrazine inhibitor C50 |
| 6NPZ |
2.12 |
Crystal structure of Akt1 (aa 123-480) kinase with a bisubstrate |
| 6TCU |
2.14 |
Glycogen synthase kinase-3 beta (GSK3b) in complex with ligand 1 |
| 6V6L |
2.19 |
Co-structure of human glycogen synthase kinase beta with 1-(6-((2-((6-amino-5-nitropyridin-2-yl)amino)ethyl)amino)-2-(2,4-dichlorophenyl)pyridin-3-yl)-4-methylpiperazin-2-one |
| 6Y9R |
2.08 |
Crystal structure of GSK-3b in complex with the 1H-indazole-3-carboxamide inhibitor 2 |
| 6Y9S |
2.03 |
Crystal structure of GSK-3b in complex with the imidazo[1,5-a]pyridine-3-carboxamide inhibitor 16 |
| 7B6F |
2.05 |
GSK3-beta in complex with compound (S)-5c |
| 7OY5 |
2.57 |
Crystal structure of GSK3Beta in complex with ARN25068 |
| 7U2Z |
2.21 |
Crystal structure of human GSK3B in complex with G12 |
| 7U31 |
2.38 |
Crystal structure of human GSK3B in complex with G5 |
| 7U33 |
2.6 |
Crystal structure of human GSK3B in complex with ARN9133 |
| 7U36 |
2.75 |
Crystal structure of human GSK3B in complex with ARN1484 |
| 7Z1F |
3.0 |
Crystal structure of GSK3b in complex with CX-4945 |
| 7Z1G |
2.85 |
Crystal structure of nonphosphorylated (Tyr216) GSK3b in complex with CX-4945 |
| 8DJC |
2.463 |
CRYSTAL STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH (4S)-N-{4-[(2S)-2-methylmorpholin-4-yl] pyridin-3-yl}-2-phenylimidazo[1,2-b]pyridazine-8-carboxamide |
| 8DJD |
2.205 |
CRYSTAL STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 3-[(CYCLOPROPYLMETHYL)AMINO] -N-(4-PHENYLPYRIDIN-3-YL)IMIDAZO[1,2-B]PYRIDAZINE-8-CARBOX AMIDE |
| 8DJE |
2.374 |
CRYSTAL STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 3-[(CYCLOPROPYLMETHYL)AMINO] -N-(4-PHENYLPYRIDIN-3-YL)IMIDAZO[1,2-B]PYRIDAZINE-8-CARBOX AMIDE |
