Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.1.77
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor;
nucleoside phosphotransferase
3.1.3.5
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
5′-nucleotidase
3.1.3.99
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases;
IMP-specific 5′-nucleotidase
PDB | Resolution (Å) | PDB name |
---|---|---|
2J2C | 2.2 | Crystal structure of Human Cytosolic 5'-Nucleotidase II (NT5C2, cN-II) |
2JC9 | 1.5 | Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with adenosine |
2JCM | 2.15 | Crystal structure of Human Cytosolic 5'-Nucleotidase II in complex with beryllium trifluoride |
2XCV | 2.3 | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inosine monophosphate and 2,3-bisphosphoglycerate |
2XCW | 1.9 | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inosine monophosphate and ATP |
2XCX | 2.3 | Crystal structure of the apoform of the D52N variant of cytosolic 5'- nucleotidase II |
2XJB | 2.3 | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with deoxyguanosine monophosphate and deoxyadenosine triphosphate |
2XJC | 2.0 | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with guanosine monophosphate and diadenosine tetraphosphate |
2XJD | 2.0 | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with inorganic phosphate and deoxyadenosine triphosphate |
2XJE | 2.3 | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II in complex with uridine 5'-monophosphate and adenosine triphosphate |
2XJF | 2.1 | Crystal structure of the D52N variant of cytosolic 5'-nucleotidase II with a covalently modified Asn52 |
4H4B | 2.9 | Human cytosolic 5'-nucleotidase II in complex with Anthraquinone-2,6- disulfonic acid |
5CQZ | 2.9 | Human cytosolic 5'-nucleotidase II in complex with 3-(3-Imidazol-1-ylphenyl)-N-(9H-purin-6-yl)benzamide |
5CR7 | 2.9 | Human cytosolic 5'-nucleotidase II in complex with N-(9H-Purin-6-yl)-3-(3-pyrrol-1-ylphenyl)benzamide |
5K7Y | 1.79 | Crystal structure of enzyme in purine metabolism |
5L4Z | 1.84 | Crystal structure of enzyme in purine metabolism |
5L50 | 1.643 | Crystal structure of enzyme in purine metabolism |
5OPK | 1.74 | Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate |
5OPL | 1.8 | Crystal structure of K25E cN-II mutant |
5OPM | 1.68 | Crystal structure of D52N/R238W cN-II mutant bound to dATP and free phosphate |
5OPN | 1.77 | Crystal structure of R39Q cN-II mutant |
5OPO | 2.0 | Crystal structure of R238G cN-II mutant |
5OPP | 1.7 | Crystal structure of S408R cN-II mutant |
6DD3 | 1.98 | Crystal structure of the double mutant (D52N/D407A) of NT5C2-537X in the active state |
6DDB | 2.8 | Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target |
6DDC | 2.91 | Crystal structure of the single mutant (D52N) of NT5C2-537X in the basal state, Northeast Structural Genomics Consortium Target |
6DDH | 2.35 | Crystal structure of the double mutant (D52N/R367Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target |
6DDK | 2.5 | Crystal structure of the double mutant (D52N/R367Q) of the full-length NT5C2 in the basal state |
6DDL | 2.26 | Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the basal state |
6DDO | 2.48 | Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the basal state |
6DDQ | 2.31 | Crystal structure of the double mutant (R39Q/D52N) of the full-length NT5C2 in the basal state |
6DDX | 2.901 | Crystal structure of the double mutant (D52N/L375F) of NT5C2-537X in the active state, Northeast Structural Genomics Target |
6DDY | 1.803 | Crystal structure of the double mutant (D52N/K359Q) of NT5C2-537X in the active state, Northeast Structural Genomics Target |
6DDZ | 1.97 | Crystal structure of the double mutant (D52N/R238W) of NT5C2-537X in the active state, Northeast Structural Genomics Target |
6DE0 | 2.05 | Crystal structure of the single mutant (D52N) of NT5C2-Q523X in the active state |
6DE1 | 2.151 | Crystal structure of the single mutant (D52N) of the full-length NT5C2 in the active state |
6DE2 | 2.1 | Crystal structure of the double mutant (D52N/L375F) of the full-length NT5C2 in the active state |
6DE3 | 3.06 | Crystal structure of the double mutant (R39Q/D52N) of the full-length NT5C2 in the active state |
6FIR | 2.5 | Human cytosolic 5'-nucleotidase II soaked with 5mM3-Phenyl-N-(9H-purin-6-yl)benzamide |
6FIS | 2.3 | Human cytosolic 5'-nucleotidase II soaked with 10mM 7-Benzyloxymethyl-7H-adenine |
6FIU | 2.5 | Human cytosolic 5'-nucleotidase II soaked with 10mM 2-(6-([1,1'-Biphenyl]-3-carboxamido)-9H-purin-9-yl)acetic acid |
6FIW | 2.2 | Human cytosolic 5'-nucleotidase II co-crystallized with 10mM Sodium ((4-(3'-((7H-purin-6-yl)carbamoyl)-[1,1'-biphenyl]-3-yl)-1H-imidazol-1-yl) methyl) phosphonate |
6FXH | 2.3 | Human cytosolic 5'-nucleotidase II soaked with 10mM 3-Phenyl-N-(9H-purin-6-yl)benzamide |
GO ontology
|
GO term | GO description |
---|---|---|
Biological Process | GO:0046037 | GMP metabolic process |
Biological Process | GO:0006204 | IMP catabolic process |
Biological Process | GO:0046040 | IMP metabolic process |
Biological Process | GO:0046085 | adenosine metabolic process |
Biological Process | GO:0000255 | allantoin metabolic process |
Biological Process | GO:0046054 | dGMP metabolic process |
Biological Process | GO:0050689 | negative regulation of defense response to virus by host |
Biological Process | GO:0070936 | protein K48-linked ubiquitination |
Molecular Function | GO:0008253 | 5'-nucleotidase activity |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0050484 | GMP 5'-nucleotidase activity |
Molecular Function | GO:0050483 | IMP 5'-nucleotidase activity |
Molecular Function | GO:0106411 | XMP 5'-nucleosidase activity |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0046872 | metal ion binding |
Molecular Function | GO:0050146 | nucleoside phosphotransferase activity |
Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-2161541 | Abacavir metabolism | Leaf | R-HSA-9748784 | Drug ADME |
R-HSA-74259 | Purine catabolism | Internal node | R-HSA-1430728 | Metabolism |
R-HSA-9755088 | Ribavirin ADME | Leaf | R-HSA-9748784 | Drug ADME |
Location
|
ECO term
|
Pubmed |
---|---|---|
Cytoplasm, cytosol | ECO:0000269 | PubMed:9371705 |
HPO ID
|
HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000486 | Strabismus |
HP:0000545 | Myopia |
HP:0000639 | Nystagmus |
HP:0000648 | Optic atrophy |
HP:0001249 | Intellectual disability |
HP:0001258 | Spastic paraplegia |
HP:0001263 | Global developmental delay |
HP:0001270 | Motor delay |
HP:0001347 | Hyperreflexia |
HP:0001371 | Flexion contracture |
HP:0001762 | Talipes equinovarus |
HP:0002061 | Lower limb spasticity |
HP:0002064 | Spastic gait |
HP:0002079 | Hypoplasia of the corpus callosum |
HP:0003202 | Skeletal muscle atrophy |
HP:0003487 | Babinski sign |
HP:0003621 | Juvenile onset |
HP:0005830 | Flexion contracture of toe |
HP:0006380 | Knee flexion contracture |
HP:0006466 | Ankle flexion contracture |
HP:0006989 | Dysplastic corpus callosum |
HP:0011462 | Young adult onset |
HP:0011463 | Childhood onset |
HP:0012043 | Pendular nystagmus |
Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
---|---|---|---|---|---|
hereditary spastic paraplegia 45 | MONDO:0013165 | G11 | chapter6, Diseases of the nervous system | OMIM:613162 | Orphanet:320396 |