Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.6.5.5
Hydrolases;
Acting on acid anhydrides;
Acting on GTP to facilitate cellular and subcellular movement;
dynamin GTPase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2YS1 | Solution structure of the PH domain of Dynamin-2 from human |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0002031 | G protein-coupled receptor internalization |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0006893 | Golgi to plasma membrane transport |
| Biological Process | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| Biological Process | GO:0071481 | cellular response to X-ray |
| Biological Process | GO:0071245 | cellular response to carbon monoxide |
| Biological Process | GO:1903351 | cellular response to dopamine |
| Biological Process | GO:0071732 | cellular response to nitric oxide |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0044351 | macropinocytosis |
| Biological Process | GO:0061024 | membrane organization |
| Biological Process | GO:1903526 | negative regulation of membrane tubulation |
| Biological Process | GO:1902856 | negative regulation of non-motile cilium assembly |
| Biological Process | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0006909 | phagocytosis |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:1903408 | positive regulation of P-type sodium:potassium-exchanging transporter activity |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:2000370 | positive regulation of clathrin-dependent endocytosis |
| Biological Process | GO:0010592 | positive regulation of lamellipodium assembly |
| Biological Process | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| Biological Process | GO:0050766 | positive regulation of phagocytosis |
| Biological Process | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| Biological Process | GO:0006892 | post-Golgi vesicle-mediated transport |
| Biological Process | GO:0031623 | receptor internalization |
| Biological Process | GO:0006898 | receptor-mediated endocytosis |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:1903358 | regulation of Golgi organization |
| Biological Process | GO:0035020 | regulation of Rac protein signal transduction |
| Biological Process | GO:0030516 | regulation of axon extension |
| Biological Process | GO:0042220 | response to cocaine |
| Biological Process | GO:0009416 | response to light stimulus |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0007283 | spermatogenesis |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
| Biological Process | GO:0048489 | synaptic vesicle transport |
| Biological Process | GO:0033572 | transferrin transport |
| Molecular Function | GO:0031749 | D2 dopamine receptor binding |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0050699 | WW domain binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0036312 | phosphatidylinositol 3-kinase regulatory subunit binding |
| Molecular Function | GO:0120283 | protein serine/threonine kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0045334 | clathrin-coated endocytic vesicle |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030666 | endocytic vesicle membrane |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0001891 | phagocytic cup |
| Cellular Component | GO:0030670 | phagocytic vesicle membrane |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0099092 | postsynaptic density, intracellular component |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0032587 | ruffle membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| InterPro
|
InterPro name |
|---|---|
| IPR000375 | Dynamin stalk domain |
| IPR001401 | Dynamin, GTPase domain |
| IPR001849 | Pleckstrin homology domain |
| IPR003130 | Dynamin GTPase effector |
| IPR011993 | PH-like domain superfamily |
| IPR019762 | Dynamin, GTPase region, conserved site |
| IPR020850 | GTPase effector domain |
| IPR022812 | Dynamin |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR030381 | Dynamin-type guanine nucleotide-binding (G) domain |
| IPR045063 | Dynamin, N-terminal |
| Pfam
|
Pfam name |
|---|---|
| PF00169 | PH domain |
| PF00350 | Dynamin family |
| PF01031 | Dynamin central region |
| PF02212 | Dynamin GTPase effector domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade | Internal node | R-HSA-168256 | Immune System |
| R-HSA-177504 | Retrograde neurotrophin signalling | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-190873 | Gap junction degradation | Internal node | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-196025 | Formation of annular gap junctions | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-203641 | NOSTRIN mediated eNOS trafficking | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-2132295 | MHC class II antigen presentation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-432720 | Lysosome Vesicle Biogenesis | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-432722 | Golgi Associated Vesicle Biogenesis | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-437239 | Recycling pathway of L1 | Leaf | R-HSA-1266738 | Developmental Biology |
| R-HSA-8856828 | Clathrin-mediated endocytosis | Internal node | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-9031628 | NGF-stimulated transcription | Leaf | R-HSA-162582 | Signal Transduction |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell junction | ECO:0000250 | |
| Cell projection, phagocytic cup | ECO:0000250 | |
| Cytoplasm | ||
| Cytoplasm, cytoskeleton | ||
| Cytoplasmic vesicle, phagosome membrane | ECO:0000250 | |
| Membrane, clathrin-coated pit | ECO:0000250 | |
| Midbody | ||
| Postsynaptic density | ||
| Synapse |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000020 | Urinary incontinence |
| HP:0000028 | Cryptorchidism |
| HP:0000508 | Ptosis |
| HP:0000544 | External ophthalmoplegia |
| HP:0000573 | Retinal hemorrhage |
| HP:0000762 | Decreased nerve conduction velocity |
| HP:0000764 | Peripheral axonal degeneration |
| HP:0000883 | Thin ribs |
| HP:0001048 | Cavernous hemangioma |
| HP:0001252 | Hypotonia |
| HP:0001265 | Hyporeflexia |
| HP:0001270 | Motor delay |
| HP:0001284 | Areflexia |
| HP:0001290 | Generalized hypotonia |
| HP:0001371 | Flexion contracture |
| HP:0001436 | Abnormality of the foot musculature |
| HP:0001518 | Small for gestational age |
| HP:0001520 | Large for gestational age |
| HP:0001522 | Death in infancy |
| HP:0001558 | Decreased fetal movement |
| HP:0001561 | Polyhydramnios |
| HP:0001761 | Pes cavus |
| HP:0002021 | Pyloric stenosis |
| HP:0002047 | Malignant hyperthermia |
| HP:0002093 | Respiratory insufficiency |
| HP:0002194 | Delayed gross motor development |
| HP:0002355 | Difficulty walking |
| HP:0002460 | Distal muscle weakness |
| HP:0002522 | Areflexia of lower limbs |
| HP:0002747 | Respiratory insufficiency due to muscle weakness |
| HP:0002803 | Congenital contracture |
| HP:0002936 | Distal sensory impairment |
| HP:0003236 | Elevated circulating creatine kinase concentration |
| HP:0003307 | Hyperlordosis |
| HP:0003380 | Decreased number of peripheral myelinated nerve fibers |
| HP:0003383 | Onion bulb formation |
| HP:0003388 | Easy fatigability |
| HP:0003458 | EMG: myopathic abnormalities |
| HP:0003477 | Peripheral axonal neuropathy |
| HP:0003481 | Segmental peripheral demyelination/remyelination |
| HP:0003577 | Congenital onset |
| HP:0003593 | Infantile onset |
| HP:0003621 | Juvenile onset |
| HP:0003677 | Slowly progressive |
| HP:0003687 | Centrally nucleated skeletal muscle fibers |
| HP:0003693 | Distal amyotrophy |
| HP:0003701 | Proximal muscle weakness |
| HP:0003712 | Skeletal muscle hypertrophy |
| HP:0003738 | Exercise-induced myalgia |
| HP:0003803 | Type 1 muscle fiber predominance |
| HP:0004488 | Macrocephaly at birth |
| HP:0005268 | Miscarriage |
| HP:0005335 | Sleepy facial expression |
| HP:0007107 | Segmental peripheral demyelination |
| HP:0007126 | Proximal amyotrophy |
| HP:0008180 | Mildly elevated creatine kinase |
| HP:0008948 | Proximal upper limb amyotrophy |
| HP:0008981 | Calf muscle hypertrophy |
| HP:0008994 | Proximal muscle weakness in lower limbs |
| HP:0008997 | Proximal muscle weakness in upper limbs |
| HP:0009053 | Distal lower limb muscle weakness |
| HP:0010546 | Muscle fibrillation |
| HP:0010628 | Facial palsy |
| HP:0010851 | EEG with burst suppression |
| HP:0012768 | Neonatal asphyxia |
| HP:0030007 | EMG: positive sharp waves |
| HP:0040078 | Axonal degeneration |
| HP:0100284 | EMG: myotonic discharges |
| HP:0100309 | Subdural hemorrhage |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Supported |
| appendix | glandular cells | High | Supported |
| appendix | lymphoid tissue | Medium | Supported |
| breast | glandular cells | Medium | Supported |
| breast | myoepithelial cells | Low | Supported |
| bronchus | respiratory epithelial cells | Medium | Supported |
| caudate | glial cells | Medium | Supported |
| cerebellum | white matter cells - cytoplasm/membrane | Medium | Supported |
| cerebral cortex | endothelial cells | Medium | Supported |
| cerebral cortex | glial cells | Low | Supported |
| cerebral cortex | neuronal cells | Low | Supported |
| cerebral cortex | neuropil | Low | Supported |
| cervix | glandular cells | Medium | Supported |
| cervix | squamous epithelial cells | Medium | Supported |
| colon | endothelial cells | Medium | Supported |
| colon | glandular cells | High | Supported |
| duodenum | glandular cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | Medium | Supported |
| endometrium 1 | glandular cells | High | Supported |
| endometrium 2 | cells in endometrial stroma | Low | Supported |
| endometrium 2 | glandular cells | High | Supported |
| epididymis | glandular cells | Medium | Supported |
| esophagus | squamous epithelial cells | High | Supported |
| fallopian tube | glandular cells | High | Supported |
| gallbladder | glandular cells | High | Supported |
| heart muscle | cardiomyocytes | Medium | Supported |
| hippocampus | glial cells | Low | Supported |
| kidney | cells in glomeruli | Low | Supported |
| kidney | cells in tubules | High | Supported |
| liver | hepatocytes | Low | Supported |
| lung | alveolar cells type II | Low | Supported |
| lung | macrophages | Medium | Supported |
| lymph node | germinal center cells | Medium | Supported |
| lymph node | non-germinal center cells | High | Supported |
| nasopharynx | respiratory epithelial cells | High | Supported |
| oral mucosa | squamous epithelial cells | Medium | Supported |
| pancreas | exocrine glandular cells | Medium | Supported |
| pancreas | pancreatic endocrine cells | Low | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | Medium | Supported |
| seminal vesicle | glandular cells | Medium | Supported |
| skeletal muscle | myocytes | Low | Supported |
| skin 1 | Langerhans | Low | Supported |
| skin 1 | keratinocytes | Medium | Supported |
| skin 1 | melanocytes | Low | Supported |
| skin 2 | epidermal cells | Medium | Supported |
| small intestine | glandular cells | High | Supported |
| smooth muscle | smooth muscle cells | Low | Supported |
| soft tissue 1 | fibroblasts | Low | Supported |
| soft tissue 2 | fibroblasts | Low | Supported |
| spleen | cells in red pulp | Medium | Supported |
| spleen | cells in white pulp | High | Supported |
| stomach 1 | glandular cells | High | Supported |
| stomach 2 | glandular cells | High | Supported |
| testis | sertoli cells | Medium | Supported |
| tonsil | germinal center cells | Medium | Supported |
| tonsil | non-germinal center cells | High | Supported |
| tonsil | squamous epithelial cells | High | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | Medium | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| autosomal dominant centronuclear myopathy | MONDO:0008048 | G71 | chapter6, Diseases of the nervous system | OMIM:160150 | Orphanet:169189 |
| autosomal dominant centronuclear myopathy | MONDO:0008048 | G71 | chapter6, Diseases of the nervous system | OMIM:614408 | Orphanet:169189 |
| x-linked centronuclear myopathy | MONDO:0010683 | G71 | chapter6, Diseases of the nervous system | OMIM:310400 | Orphanet:596 |
| fetal akinesia-cerebral and retinal hemorrhage syndrome | MONDO:0014149 | G71 | chapter6, Diseases of the nervous system | OMIM:615368 | Orphanet:363409 |
| autosomal dominant charcot-marie-tooth disease type 2m | MONDO:0016431 | G60 | chapter6, Diseases of the nervous system | Orphanet:228179 |