Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.11.22
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
cyclin-dependent kinase
2.7.11.23
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
[RNA-polymerase]-subunit kinase
PDB | Resolution (Å) | PDB name |
---|---|---|
1UA2 | 3.02 | Crystal Structure of Human CDK7 |
6O9L | 7.2 | Human holo-PIC in the closed state |
6XBZ | 2.8 | Structure of the human CDK-activating kinase |
6XD3 | 3.3 | Structure of the human CAK in complex with THZ1 |
7B5O | 2.5 | Cryo-EM structure of the human CAK bound to ICEC0942 at 2.5 Angstroms resolution |
7B5Q | 2.5 | Cryo-EM structure of the human CAK bound to ICEC0942 (PHENIX-OPLS3e) |
7EGB | 3.3 | TFIID-based holo PIC on SCP promoter |
7EGC | 3.9 | p53-bound TFIID-based holo PIC on HDM2 promoter |
7ENA | 4.07 | TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED) |
7ENC | 4.13 | TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED) |
7LBM | 4.8 | Structure of the human Mediator-bound transcription pre-initiation complex |
7NVR | 4.5 | Human Mediator with RNA Polymerase II Pre-initiation complex |
8GXQ | 5.04 | PIC-Mediator in complex with +1 nucleosome (T40N) in MH-binding state |
8GXS | 4.16 | PIC-Mediator in complex with +1 nucleosome (T40N) in H-binding state |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006281 | DNA repair |
Biological Process | GO:0007049 | cell cycle |
Biological Process | GO:0051301 | cell division |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Biological Process | GO:0006468 | protein phosphorylation |
Biological Process | GO:0050821 | protein stabilization |
Biological Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
Biological Process | GO:0051726 | regulation of cell cycle |
Biological Process | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity |
Biological Process | GO:0042795 | snRNA transcription by RNA polymerase II |
Biological Process | GO:0006366 | transcription by RNA polymerase II |
Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0008094 | ATP-dependent activity, acting on DNA |
Molecular Function | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity |
Molecular Function | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
Molecular Function | GO:0004672 | protein kinase activity |
Molecular Function | GO:0106310 | protein serine kinase activity |
Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
Cellular Component | GO:0070516 | CAK-ERCC2 complex |
Cellular Component | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0001650 | fibrillar center |
Cellular Component | GO:0001673 | male germ cell nucleus |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
Cellular Component | GO:0005886 | plasma membrane |
Cellular Component | GO:0000439 | transcription factor TFIIH core complex |
Cellular Component | GO:0005675 | transcription factor TFIIH holo complex |
Cellular Component | GO:0070985 | transcription factor TFIIK complex |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-112382 | Formation of RNA Pol II elongation complex | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-113418 | Formation of the Early Elongation Complex | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | Leaf | R-HSA-1643685 | Disease |
R-HSA-167158 | Formation of the HIV-1 Early Elongation Complex | Leaf | R-HSA-1643685 | Disease |
R-HSA-167160 | RNA Pol II CTD phosphorylation and interaction with CE during HIV infection | Leaf | R-HSA-1643685 | Disease |
R-HSA-167161 | HIV Transcription Initiation | Leaf | R-HSA-1643685 | Disease |
R-HSA-167162 | RNA Polymerase II HIV Promoter Escape | Leaf | R-HSA-1643685 | Disease |
R-HSA-167172 | Transcription of the HIV genome | Internal node | R-HSA-1643685 | Disease |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | Leaf | R-HSA-1643685 | Disease |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | Internal node | R-HSA-1643685 | Disease |
R-HSA-427413 | NoRC negatively regulates rRNA expression | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-5696395 | Formation of Incision Complex in GG-NER | Leaf | R-HSA-73894 | DNA Repair |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-6781823 | Formation of TC-NER Pre-Incision Complex | Leaf | R-HSA-73894 | DNA Repair |
R-HSA-6781827 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | Internal node | R-HSA-73894 | DNA Repair |
R-HSA-6782135 | Dual incision in TC-NER | Leaf | R-HSA-73894 | DNA Repair |
R-HSA-6782210 | Gap-filling DNA repair synthesis and ligation in TC-NER | Leaf | R-HSA-73894 | DNA Repair |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-69202 | Cyclin E associated events during G1/S transition | Internal node | R-HSA-1640170 | Cell Cycle |
R-HSA-69231 | Cyclin D associated events in G1 | Internal node | R-HSA-1640170 | Cell Cycle |
R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | Internal node | R-HSA-1640170 | Cell Cycle |
R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry | Internal node | R-HSA-1640170 | Cell Cycle |
R-HSA-72086 | mRNA Capping | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-73762 | RNA Polymerase I Transcription Initiation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-73772 | RNA Polymerase I Promoter Escape | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-73776 | RNA Polymerase II Promoter Escape | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-73779 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-73863 | RNA Polymerase I Transcription Termination | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-75953 | RNA Polymerase II Transcription Initiation | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | Internal node | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-76042 | RNA Polymerase II Transcription Initiation And Promoter Clearance | Internal node | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-77075 | RNA Pol II CTD phosphorylation and interaction with CE | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | Leaf | R-HSA-74160 | Gene expression (Transcription) |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:15695176 |
Cytoplasm, perinuclear region | ECO:0000269 | PubMed:19071173 |
Nucleus | ECO:0000269 | PubMed:10958787 |
Nucleus | ECO:0000269 | PubMed:15695176 |
Nucleus | ECO:0000269 | PubMed:19071173 |