MultifacetedProtDB - Bologna Biocomputing Group

Summary of P50613

Gene: CDK7, CAK, CAK1, CDKN7, MO15, STK1
Protein: Cyclin-dependent kinase 7

Protein family
Protein sequence
Protein function

Catalytic activity

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EC number	EC number description
2.7.11.22	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; cyclin-dependent kinase
2.7.11.23	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; [RNA-polymerase]-subunit kinase

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Publications

Structure

Link to AlphaFold model

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PDB	Resolution (Å)	PDB name
1UA2	3.02	Crystal Structure of Human CDK7
6O9L	7.2	Human holo-PIC in the closed state
6XBZ	2.8	Structure of the human CDK-activating kinase
6XD3	3.3	Structure of the human CAK in complex with THZ1
7B5O	2.5	Cryo-EM structure of the human CAK bound to ICEC0942 at 2.5 Angstroms resolution
7B5Q	2.5	Cryo-EM structure of the human CAK bound to ICEC0942 (PHENIX-OPLS3e)
7EGB	3.3	TFIID-based holo PIC on SCP promoter
7EGC	3.9	p53-bound TFIID-based holo PIC on HDM2 promoter
7ENA	4.07	TFIID-based PIC-Mediator holo-complex in pre-assembled state (pre-hPIC-MED)
7ENC	4.13	TFIID-based PIC-Mediator holo-complex in fully-assembled state (hPIC-MED)

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GO term

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GO ontology	GO term	GO description
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0007049	cell cycle
Biological Process	GO:0051301	cell division
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0050821	protein stabilization
Biological Process	GO:2000045	regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0051726	regulation of cell cycle
Biological Process	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process	GO:0042795	snRNA transcription by RNA polymerase II

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InterPro / Pfam

Reactome

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Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-112382	Formation of RNA Pol II elongation complex	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-113418	Formation of the Early Elongation Complex	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	Leaf	R-HSA-1643685	Disease
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	Leaf	R-HSA-1643685	Disease
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	Leaf	R-HSA-1643685	Disease
R-HSA-167161	HIV Transcription Initiation	Leaf	R-HSA-1643685	Disease
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	Leaf	R-HSA-1643685	Disease
R-HSA-167172	Transcription of the HIV genome	Internal node	R-HSA-1643685	Disease
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	Leaf	R-HSA-1643685	Disease
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	Internal node	R-HSA-1643685	Disease

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Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

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Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Enhanced
appendix	glandular cells	Low	Enhanced
bone marrow	hematopoietic cells	Medium	Enhanced
breast	glandular cells	High	Enhanced
breast	myoepithelial cells	High	Enhanced
bronchus	basal cells	High	Enhanced
bronchus	ciliated cells (cell body)	High	Enhanced
bronchus	goblet cells	High	Enhanced
caudate	glial cells	Medium	Enhanced
caudate	neuronal cells	Medium	Enhanced

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Disease