Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.11.22
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
cyclin-dependent kinase
2.7.11.23
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
[RNA-polymerase]-subunit kinase
PDB | Resolution (Å) | PDB name |
---|---|---|
3BLH | 2.48 | Crystal Structure of Human CDK9/cyclinT1 |
3BLQ | 2.9 | Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP |
3BLR | 2.8 | Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol |
3LQ5 | 3.0 | Structure of CDK9/CyclinT in complex with S-CR8 |
3MI9 | 2.1 | Crystal structure of HIV-1 Tat complexed with human P-TEFb |
3MIA | 3.0 | Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb |
3MY1 | 2.8 | Structure of CDK9/cyclinT1 in complex with DRB |
3TN8 | 2.95 | CDK9/cyclin T in complex with CAN508 |
3TNH | 3.202 | CDK9/cyclin T in complex with CAN508 |
3TNI | 3.234 | structure of CDK9/cyclin T F241L |
4BCF | 3.011 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
4BCG | 3.085 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
4BCH | 2.958 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
4BCI | 3.1 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
4BCJ | 3.162 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
4EC8 | 3.6 | Structure of full length CDK9 in complex with cyclinT and DRB |
4EC9 | 3.21 | Crystal structure of full-length cdk9 in complex with cyclin t |
4IMY | 2.94 | The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat |
4OGR | 3.0 | crystal structure of P-TEFb complex with AFF4 and Tat |
4OR5 | 2.9 | Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 |
5L1Z | 5.9 | TAR complex with HIV-1 Tat-AFF4-P-TEFb |
6CYT | 3.5 | HIV-1 TAR loop in complex with Tat:AFF4:P-TEFb |
6GZH | 3.17 | Crystal Structure of Human CDK9/cyclinT1 with A86 |
6W9E | 3.1 | Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295 |
6Z45 | 3.37 | CDK9-Cyclin-T1 complex bound by compound 24 |
7NWK | 2.81 | Crystal structure of CDK9-Cyclin T1 bound by compound 6 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006281 | DNA repair |
Biological Process | GO:0008283 | cell population proliferation |
Biological Process | GO:0071345 | cellular response to cytokine stimulus |
Biological Process | GO:0120186 | negative regulation of protein localization to chromatin |
Biological Process | GO:0051647 | nucleus localization |
Biological Process | GO:0043923 | positive regulation by host of viral transcription |
Biological Process | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
Biological Process | GO:0120187 | positive regulation of protein localization to chromatin |
Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Biological Process | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II |
Biological Process | GO:0006468 | protein phosphorylation |
Biological Process | GO:0006282 | regulation of DNA repair |
Biological Process | GO:0051726 | regulation of cell cycle |
Biological Process | GO:0031440 | regulation of mRNA 3'-end processing |
Biological Process | GO:0051147 | regulation of muscle cell differentiation |
Biological Process | GO:0031297 | replication fork processing |
Biological Process | GO:0009410 | response to xenobiotic stimulus |
Biological Process | GO:0006366 | transcription by RNA polymerase II |
Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
Biological Process | GO:0140673 | transcription elongation-coupled chromatin remodeling |
Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
Molecular Function | GO:0097322 | 7SK snRNA binding |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0003677 | DNA binding |
Molecular Function | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity |
Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
Molecular Function | GO:0003682 | chromatin binding |
Molecular Function | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
Molecular Function | GO:0016301 | kinase activity |
Molecular Function | GO:0140677 | molecular function activator activity |
Molecular Function | GO:0140678 | molecular function inhibitor activity |
Molecular Function | GO:0004672 | protein kinase activity |
Molecular Function | GO:0019901 | protein kinase binding |
Molecular Function | GO:0106310 | protein serine kinase activity |
Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
Molecular Function | GO:0001223 | transcription coactivator binding |
Cellular Component | GO:0070691 | P-TEFb complex |
Cellular Component | GO:0016605 | PML body |
Cellular Component | GO:0008024 | cyclin/CDK positive transcription elongation factor complex |
Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0008023 | transcription elongation factor complex |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-112382 | Formation of RNA Pol II elongation complex | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | Leaf | R-HSA-1643685 | Disease |
R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | Leaf | R-HSA-1643685 | Disease |
R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | Leaf | R-HSA-1643685 | Disease |
R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | Leaf | R-HSA-1643685 | Disease |
R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | Internal node | R-HSA-1643685 | Disease |
R-HSA-167287 | HIV elongation arrest and recovery | Leaf | R-HSA-1643685 | Disease |
R-HSA-167290 | Pausing and recovery of HIV elongation | Leaf | R-HSA-1643685 | Disease |
R-HSA-176034 | Interactions of Tat with host cellular proteins | Leaf | R-HSA-1643685 | Disease |
R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-674695 | RNA Polymerase II Pre-transcription Events | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-75955 | RNA Polymerase II Transcription Elongation | Internal node | R-HSA-74160 | Gene expression (Transcription) |
R-HSA-9018519 | Estrogen-dependent gene expression | Leaf | R-HSA-162582 | Signal Transduction |