Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.11.22
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
cyclin-dependent kinase
2.7.11.23
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
[RNA-polymerase]-subunit kinase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3BLH | 2.48 | Crystal Structure of Human CDK9/cyclinT1 |
| 3BLQ | 2.9 | Crystal Structure of Human CDK9/cyclinT1 in Complex with ATP |
| 3BLR | 2.8 | Crystal Structure of Human CDK9/cyclinT1 in complex with Flavopiridol |
| 3LQ5 | 3.0 | Structure of CDK9/CyclinT in complex with S-CR8 |
| 3MI9 | 2.1 | Crystal structure of HIV-1 Tat complexed with human P-TEFb |
| 3MIA | 3.0 | Crystal structure of HIV-1 Tat complexed with ATP-bound human P-TEFb |
| 3MY1 | 2.8 | Structure of CDK9/cyclinT1 in complex with DRB |
| 3TN8 | 2.95 | CDK9/cyclin T in complex with CAN508 |
| 3TNH | 3.202 | CDK9/cyclin T in complex with CAN508 |
| 3TNI | 3.234 | structure of CDK9/cyclin T F241L |
| 4BCF | 3.011 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
| 4BCG | 3.085 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
| 4BCH | 2.958 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
| 4BCI | 3.1 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
| 4BCJ | 3.162 | Structure of CDK9 in complex with cyclin T and a 2-amino-4-heteroaryl- pyrimidine inhibitor |
| 4EC8 | 3.6 | Structure of full length CDK9 in complex with cyclinT and DRB |
| 4EC9 | 3.21 | Crystal structure of full-length cdk9 in complex with cyclin t |
| 4IMY | 2.94 | The AFF4 scaffold binds human P-TEFb adjacent to HIV Tat |
| 4OGR | 3.0 | crystal structure of P-TEFb complex with AFF4 and Tat |
| 4OR5 | 2.9 | Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4 |
| 5L1Z | 5.9 | TAR complex with HIV-1 Tat-AFF4-P-TEFb |
| 6CYT | 3.5 | HIV-1 TAR loop in complex with Tat:AFF4:P-TEFb |
| 6GZH | 3.17 | Crystal Structure of Human CDK9/cyclinT1 with A86 |
| 6W9E | 3.1 | Crystal Structure of Human CDK9/cyclinT1 in complex with MC180295 |
| 6Z45 | 3.37 | CDK9-Cyclin-T1 complex bound by compound 24 |
| 7NWK | 2.81 | Crystal structure of CDK9-Cyclin T1 bound by compound 6 |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0008283 | cell population proliferation |
| Biological Process | GO:0071345 | cellular response to cytokine stimulus |
| Biological Process | GO:0120186 | negative regulation of protein localization to chromatin |
| Biological Process | GO:0051647 | nucleus localization |
| Biological Process | GO:0043923 | positive regulation by host of viral transcription |
| Biological Process | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| Biological Process | GO:0120187 | positive regulation of protein localization to chromatin |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032968 | positive regulation of transcription elongation by RNA polymerase II |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0006282 | regulation of DNA repair |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:0031440 | regulation of mRNA 3'-end processing |
| Biological Process | GO:0051147 | regulation of muscle cell differentiation |
| Biological Process | GO:0031297 | replication fork processing |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0006366 | transcription by RNA polymerase II |
| Biological Process | GO:0006368 | transcription elongation by RNA polymerase II |
| Biological Process | GO:0140673 | transcription elongation-coupled chromatin remodeling |
| Biological Process | GO:0006367 | transcription initiation at RNA polymerase II promoter |
| Molecular Function | GO:0097322 | 7SK snRNA binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0008353 | RNA polymerase II CTD heptapeptide repeat kinase activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0140677 | molecular function activator activity |
| Molecular Function | GO:0140678 | molecular function inhibitor activity |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0001223 | transcription coactivator binding |
| Cellular Component | GO:0070691 | P-TEFb complex |
| Cellular Component | GO:0016605 | PML body |
| Cellular Component | GO:0008024 | cyclin/CDK positive transcription elongation factor complex |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0008023 | transcription elongation factor complex |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-112382 | Formation of RNA Pol II elongation complex | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-167152 | Formation of HIV elongation complex in the absence of HIV Tat | Leaf | R-HSA-1643685 | Disease |
| R-HSA-167200 | Formation of HIV-1 elongation complex containing HIV-1 Tat | Leaf | R-HSA-1643685 | Disease |
| R-HSA-167238 | Pausing and recovery of Tat-mediated HIV elongation | Leaf | R-HSA-1643685 | Disease |
| R-HSA-167243 | Tat-mediated HIV elongation arrest and recovery | Leaf | R-HSA-1643685 | Disease |
| R-HSA-167246 | Tat-mediated elongation of the HIV-1 transcript | Internal node | R-HSA-1643685 | Disease |
| R-HSA-167287 | HIV elongation arrest and recovery | Leaf | R-HSA-1643685 | Disease |
| R-HSA-167290 | Pausing and recovery of HIV elongation | Leaf | R-HSA-1643685 | Disease |
| R-HSA-176034 | Interactions of Tat with host cellular proteins | Leaf | R-HSA-1643685 | Disease |
| R-HSA-2173796 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-674695 | RNA Polymerase II Pre-transcription Events | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-6796648 | TP53 Regulates Transcription of DNA Repair Genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-6807505 | RNA polymerase II transcribes snRNA genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-75955 | RNA Polymerase II Transcription Elongation | Internal node | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-9018519 | Estrogen-dependent gene expression | Leaf | R-HSA-162582 | Signal Transduction |