Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.2.23
Transferases;
Acyltransferases;
Aminoacyltransferases;
E2 ubiquitin-conjugating enzyme
2.3.2.24
Transferases;
Acyltransferases;
Aminoacyltransferases;
(E3-independent) E2 ubiquitin-conjugating enzyme
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1XR9 | 1.788 | Crystal Structures of HLA-B*1501 in Complex with Peptides from Human UbcH6 and Epstein-Barr Virus EBNA-3 |
| 3BZH | 1.6 | Crystal structure of human ubiquitin-conjugating enzyme E2 E1 |
| 4JJQ | 1.95 | Crystal structure of usp7-ntd with an e2 enzyme |
| 5LBN | 1.42 | High-resolution crystal structure of the UBC core domain of UBE2E1/UbcH6 |
| 6FGA | 2.82 | Crystal structure of TRIM21 E3 ligase, RING domain in complex with its cognate E2 conjugating enzyme UBE2E1 |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0032020 | ISG15-protein conjugation |
| Biological Process | GO:0033523 | histone H2B ubiquitination |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0070936 | protein K48-linked ubiquitination |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042296 | ISG15 transferase activity |
| Molecular Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000151 | ubiquitin ligase complex |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1169408 | ISG15 antiviral mechanism | Leaf | R-HSA-168256 | Immune System |
| R-HSA-141430 | Inactivation of APC/C via direct inhibition of the APC/C complex | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-174084 | Autodegradation of Cdh1 by Cdh1:APC/C | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-174154 | APC/C:Cdc20 mediated degradation of Securin | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-176407 | Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase | Internal node | R-HSA-1640170 | Cell Cycle |
| R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins | Internal node | R-HSA-1640170 | Cell Cycle |
| R-HSA-176412 | Phosphorylation of the APC/C | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-179409 | APC-Cdc20 mediated degradation of Nek2A | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-2467813 | Separation of Sister Chromatids | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-68867 | Assembly of the pre-replicative complex | Internal node | R-HSA-69306 | DNA Replication |
| R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | Leaf | R-HSA-69306 | DNA Replication |
| R-HSA-8853884 | Transcriptional Regulation by VENTX | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-9687136 | Aberrant regulation of mitotic exit in cancer due to RB1 defects | Leaf | R-HSA-1643685 | Disease |
| R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation | Leaf | R-HSA-168256 | Immune System |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Nucleus | ECO:0000269 | PubMed:18845142 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Approved |
| breast | glandular cells | Low | Approved |
| breast | myoepithelial cells | Low | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebellum | cells in molecular layer | Medium | Approved |
| cerebral cortex | glial cells | Low | Approved |
| cerebral cortex | neuronal cells | Low | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Low | Approved |
| colon | glandular cells | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | glandular cells | Low | Approved |
| endometrium 2 | glandular cells | Low | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| lymph node | germinal center cells | Low | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Medium | Approved |
| placenta | decidual cells | Low | Approved |
| rectum | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | Low | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Low | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| soft tissue 1 | chondrocytes | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Low | Approved |
| testis | pachytene spermatocytes | Medium | Approved |
| testis | round or early spermatids | Low | Approved |
| testis | sertoli cells | Medium | Approved |
| testis | spermatogonia cells | Low | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Low | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|