Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.7.1.1
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor;
hexokinase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2NZT | 2.45 | Crystal structure of human hexokinase II |
| 5HEX | 2.734 | Crystal Structure of Human Hexokinase 2 with cmpd 30, a 2-amino-6-benzenesulfonamide glucosamine |
| 5HFU | 2.923 | Crystal Structure of Human Hexokinase 2 with cmpd 27, a 2-amido-6-benzenesulfonamide glucosamine |
| 5HG1 | 2.76 | Crystal Structure of Human Hexokinase 2 with cmpd 1, a C-2-substituted glucosamine |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0008637 | apoptotic mitochondrial changes |
| Biological Process | GO:0061621 | canonical glycolysis |
| Biological Process | GO:0046835 | carbohydrate phosphorylation |
| Biological Process | GO:1990830 | cellular response to leukemia inhibitory factor |
| Biological Process | GO:0072655 | establishment of protein localization to mitochondrion |
| Biological Process | GO:0006002 | fructose 6-phosphate metabolic process |
| Biological Process | GO:0051156 | glucose 6-phosphate metabolic process |
| Biological Process | GO:0006006 | glucose metabolic process |
| Biological Process | GO:0006096 | glycolytic process |
| Biological Process | GO:0001678 | intracellular glucose homeostasis |
| Biological Process | GO:0007595 | lactation |
| Biological Process | GO:0072656 | maintenance of protein location in mitochondrion |
| Biological Process | GO:0035795 | negative regulation of mitochondrial membrane permeability |
| Biological Process | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| Biological Process | GO:0045766 | positive regulation of angiogenesis |
| Biological Process | GO:1904925 | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization |
| Biological Process | GO:0046324 | regulation of glucose import |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0002931 | response to ischemia |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0008865 | fructokinase activity |
| Molecular Function | GO:0004340 | glucokinase activity |
| Molecular Function | GO:0005536 | glucose binding |
| Molecular Function | GO:0004396 | hexokinase activity |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-70171 | Glycolysis | Internal node | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytosol | ECO:0000269 | PubMed:18350175 |
| Mitochondrion outer membrane | ECO:0000269 | PubMed:18350175 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | glandular cells | Medium | Enhanced |
| appendix | lymphoid tissue | Low | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| breast | glandular cells | Low | Enhanced |
| breast | myoepithelial cells | Low | Enhanced |
| bronchus | respiratory epithelial cells | Low | Enhanced |
| caudate | neuronal cells | Medium | Enhanced |
| cerebellum | cells in granular layer | Medium | Enhanced |
| cerebellum | cells in molecular layer | Low | Enhanced |
| cerebral cortex | endothelial cells | Low | Enhanced |
| cerebral cortex | glial cells | Low | Enhanced |
| cerebral cortex | neuronal cells | Medium | Enhanced |
| cerebral cortex | neuropil | Low | Enhanced |
| cervix | glandular cells | Low | Enhanced |
| colon | glandular cells | Low | Enhanced |
| colon | peripheral nerve/ganglion | Low | Enhanced |
| duodenum | glandular cells | Low | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | High | Enhanced |
| esophagus | squamous epithelial cells | Low | Enhanced |
| fallopian tube | glandular cells | Low | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| heart muscle | cardiomyocytes | Medium | Enhanced |
| hippocampus | neuronal cells | Medium | Enhanced |
| kidney | cells in tubules | Medium | Enhanced |
| lung | alveolar cells | Low | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Low | Enhanced |
| pancreas | pancreatic endocrine cells | Low | Enhanced |
| parathyroid gland | glandular cells | Medium | Enhanced |
| placenta | decidual cells | Medium | Enhanced |
| placenta | trophoblastic cells | Low | Enhanced |
| prostate | glandular cells | Low | Enhanced |
| rectum | glandular cells | Medium | Enhanced |
| salivary gland | glandular cells | Low | Enhanced |
| seminal vesicle | glandular cells | Low | Enhanced |
| skeletal muscle | myocytes | Medium | Enhanced |
| skin 1 | Langerhans | Low | Enhanced |
| skin 1 | keratinocytes | Low | Enhanced |
| skin 1 | melanocytes | Low | Enhanced |
| skin 2 | epidermal cells | Low | Enhanced |
| small intestine | glandular cells | Low | Enhanced |
| soft tissue 1 | peripheral nerve | Low | Enhanced |
| soft tissue 2 | peripheral nerve | Medium | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | Medium | Enhanced |
| testis | elongated or late spermatids | Medium | Enhanced |
| testis | sertoli cells | Medium | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Low | Enhanced |
| tonsil | non-germinal center cells | Low | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|