Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
6VLZ | 2.97 | Structure of the human mitochondrial ribosome-EF-G1 complex (ClassI) |
6VMI | 2.96 | Structure of the human mitochondrial ribosome-EF-G1 complex (ClassIII) |
6ZM5 | 2.89 | Human mitochondrial ribosome in complex with OXA1L, mRNA, A/A tRNA, P/P tRNA and nascent polypeptide |
6ZM6 | 2.59 | Human mitochondrial ribosome in complex with mRNA, A/A tRNA and P/P tRNA |
6ZS9 | 4.0 | Human mitochondrial ribosome in complex with ribosome recycling factor |
6ZSA | 4.0 | Human mitochondrial ribosome bound to mRNA, A-site tRNA and P-site tRNA |
6ZSB | 4.5 | Human mitochondrial ribosome in complex with mRNA and P-site tRNA |
6ZSC | 3.5 | Human mitochondrial ribosome in complex with E-site tRNA |
6ZSD | 3.7 | Human mitochondrial ribosome in complex with mRNA, P-site tRNA and E-site tRNA |
6ZSE | 5.0 | Human mitochondrial ribosome in complex with mRNA, A/P-tRNA and P/E-tRNA |
6ZSG | 4.0 | Human mitochondrial ribosome in complex with mRNA, A-site tRNA, P-site tRNA and E-site tRNA |
7L08 | 3.49 | Cryo-EM structure of the human 55S mitoribosome-RRFmt complex. |
7L20 | 3.15 | Cryo-EM structure of the human 39S mitoribosomal subunit in complex with RRFmt and EF-G2mt. |
7O9K | 3.1 | Human mitochondrial ribosome large subunit assembly intermediate with MTERF4-NSUN4, MRM2, MTG1, the MALSU module, GTPBP5 and mtEF-Tu |
7O9M | 2.6 | Human mitochondrial ribosome large subunit assembly intermediate with MTERF4-NSUN4, MRM2, MTG1 and the MALSU module |
7OG4 | 3.8 | Human mitochondrial ribosome in complex with P/E-tRNA |
7PO2 | 3.09 | Initiation complex of human mitochondrial ribosome small subunit with IF2, fMet-tRNAMet and mRNA |
7PO4 | 2.56 | Assembly intermediate of human mitochondrial ribosome large subunit (largely unfolded rRNA with MALSU1, L0R8F8 and ACP) |
7QI4 | 2.21 | Human mitochondrial ribosome at 2.2 A resolution |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006390 | mitochondrial transcription |
Biological Process | GO:0032543 | mitochondrial translation |
Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
Biological Process | GO:0006412 | translation |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0003729 | mRNA binding |
Molecular Function | GO:0003735 | structural constituent of ribosome |
Cellular Component | GO:0005743 | mitochondrial inner membrane |
Cellular Component | GO:0005762 | mitochondrial large ribosomal subunit |
Cellular Component | GO:0005739 | mitochondrion |
InterPro | InterPro name |
---|---|
IPR000206 | Ribosomal protein L7/L12 |
IPR008932 | Ribosomal protein L7/L12, oligomerisation |
IPR013823 | Ribosomal protein L7/L12, C-terminal |
IPR014719 | Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like |
IPR036235 | Ribosomal protein L7/L12, oligomerisation domain superfamily |
Pfam | Pfam name |
---|---|
PF00542 | Ribosomal protein L7/L12 C-terminal domain |
PF16320 | Ribosomal protein L7/L12 dimerisation domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-5368286 | Mitochondrial translation initiation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-5389840 | Mitochondrial translation elongation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-5419276 | Mitochondrial translation termination | Leaf | R-HSA-392499 | Metabolism of proteins |
Location | ECO term | Pubmed |
---|---|---|
Mitochondrion | ECO:0000269 | PubMed:8626705 |
HPO ID | HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000218 | High palate |
HP:0000286 | Epicanthus |
HP:0000311 | Round face |
HP:0000369 | Low-set ears |
HP:0000470 | Short neck |
HP:0000666 | Horizontal nystagmus |
HP:0001250 | Seizure |
HP:0001251 | Ataxia |
HP:0001263 | Global developmental delay |
HP:0001324 | Muscle weakness |
HP:0001337 | Tremor |
HP:0001344 | Absent speech |
HP:0001508 | Failure to thrive |
HP:0001695 | Cardiac arrest |
HP:0002151 | Increased serum lactate |
HP:0002500 | Abnormal cerebral white matter morphology |
HP:0008347 | Decreased activity of mitochondrial complex IV |
HP:0008936 | Axial hypotonia |
HP:0011923 | Decreased activity of mitochondrial complex I |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
combined oxidative phosphorylation deficiency 45 | MONDO:0033533 | E70 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:618951 | |
combined oxidative phosphorylation deficiency 45 | MONDO:0033533 | E88 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:618951 |