Protein family
Protein sequence
Protein function
EC number | EC number description |
---|---|
1.-.-.- | Oxidoreductases; ; ; |
1.1.1.112 | Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; indanol dehydrogenase |
1.1.1.209 | Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3(or 17)α-hydroxysteroid dehydrogenase |
1.1.1.357 | Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3α-hydroxysteroid 3-dehydrogenase |
1.1.1.53 | Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3α(or 20β)-hydroxysteroid dehydrogenase |
1.1.1.62 | Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 17β-estradiol 17-dehydrogenase |
1.3.1.20 | Oxidoreductases; Acting on the CH-CH group of donors; With NAD+ or NADP+ as acceptor; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase |
PDB | Resolution (Å) | PDB name |
---|---|---|
1IHI | 3.0 | Crystal Structure of Human Type III 3-alpha-Hydroxysteroid Dehydrogenase/Bile Acid Binding Protein (AKR1C2) Complexed with NADP+ and Ursodeoxycholate |
1J96 | 1.25 | Human 3alpha-HSD type 3 in Ternary Complex with NADP and Testosterone |
1XJB | 1.9 | Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H), citrate and acetate molecules |
2HDJ | 2.0 | Crystal structure of human type 3 3alpha-hydroxysteroid dehydrogenase in complex with NADP(H) |
2IPJ | 1.8 | Crystal structure of h3alpha-hydroxysteroid dehydrogenase type 3 mutant Y24A in complex with NADP+ and epi-testosterone |
4JQ1 | 1.6 | AKR1C2 complex with naproxen |
4JQ2 | 1.75 | AKR1C2 complex with sulindac |
4JQ3 | 1.75 | AKR1C2 complex with zomepirac |
4JQ4 | 1.52 | AKR1C2 complex with indomethacin |
4JQA | 1.45 | AKR1C2 complex with mefenamic acid |
GO ontology
| GO term | GO description |
---|---|---|
Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
Biological Process | GO:0071395 | cellular response to jasmonic acid stimulus |
Biological Process | GO:0071799 | cellular response to prostaglandin D stimulus |
Biological Process | GO:0044597 | daunorubicin metabolic process |
Biological Process | GO:0007586 | digestion |
Biological Process | GO:0044598 | doxorubicin metabolic process |
Biological Process | GO:0030855 | epithelial cell differentiation |
Biological Process | GO:0008284 | positive regulation of cell population proliferation |
Biological Process | GO:0051897 | positive regulation of protein kinase B signaling |
Biological Process | GO:0042448 | progesterone metabolic process |
Reactome
| Reactome Name | Node type
| Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-193775 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol | Leaf | R-HSA-1430728 | Metabolism |
Location
| ECO term
| Pubmed |
---|---|---|
Cytoplasm, cytosol | ECO:0000305 | PubMed:8486699 |
HPO ID
| HPO name |
---|---|
HP:0000007 | Autosomal recessive inheritance |
HP:0000028 | Cryptorchidism |
HP:0000037 | Male pseudohermaphroditism |
HP:0000062 | Ambiguous genitalia |
HP:0012245 | Sex reversal |
Disease name | MONDO ID
| ICD10
| ICD10 chapter
| OMIM
| Orphanet
|
---|---|---|---|---|---|
46,xy disorder of sex development due to testicular 17,20-desmolase deficiency | MONDO:0013664 | E29 | chapter4, Endocrine, nutritional and metabolic diseases | OMIM:614279 | Orphanet:443087 |