MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.4.21.-	Hydrolases; Acting on peptide bonds (peptidases); Serine endopeptidases;

Structure

PDB	Resolution (Å)	PDB name
1KO6	3.0	Crystal Structure of C-terminal Autoproteolytic Domain of Nucleoporin Nup98
2Q5X	1.9	Crystal Structure of the C-terminal domain of hNup98
2Q5Y	2.3	Crystal Structure of the C-terminal domain of hNup98
3MMY	1.65	Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1
4OWR	3.15	Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair Rae1-Nup98
5A9Q	23.0	Human nuclear pore complex
6BZM	0.9	GFGNFGTS from low-complexity/FG repeat domain of Nup98, residues 116-123
7F60	2.85	Crystal structure of auxiliary protein in complex with human nuclear protein
7F90	2.39	Crystal structure of SARS auxiliary protein in complex with human nuclear protein
7MNI	2.0	Crystal structure of the N-terminal domain of NUP88 in complex with NUP98 C-terminal Autoproteolytic Domain
7PEQ	35.0	Model of the outer rings of the human nuclear pore complex
7Q64	2.76	Cryo-em structure of the Nup98 fibril polymorph 1
7Q65	3.32	Cryo-em structure of the Nup98 fibril polymorph 2
7Q66	2.79	Cryo-em structure of the Nup98 fibril polymorph 3
7Q67	3.37	Cryo-em structure of the Nup98 fibril polymorph 4
7VPG	2.49	Crystal structure of the C-terminal tail of SARS-CoV-1 Orf6 complex with human nucleoporin pair Rae1-Nup98
7VPH	2.8	Crystal structure of the C-terminal tail of SARS-CoV-2 Orf6 complex with human nucleoporin pair Rae1-Nup98

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006405	RNA export from nucleus
Biological Process	GO:0051028	mRNA transport
Biological Process	GO:0051292	nuclear pore complex assembly
Biological Process	GO:0006999	nuclear pore organization
Biological Process	GO:0006913	nucleocytoplasmic transport
Biological Process	GO:0048026	positive regulation of mRNA splicing, via spliceosome
Biological Process	GO:0000973	post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery
Biological Process	GO:0006606	protein import into nucleus
Biological Process	GO:0006508	proteolysis
Biological Process	GO:0034398	telomere tethering at nuclear periphery
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0008139	nuclear localization sequence binding
Molecular Function	GO:1990841	promoter-specific chromatin binding
Molecular Function	GO:0008236	serine-type peptidase activity
Molecular Function	GO:0017056	structural constituent of nuclear pore
Molecular Function	GO:0003713	transcription coactivator activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016604	nuclear body
Cellular Component	GO:0005635	nuclear envelope
Cellular Component	GO:0042405	nuclear inclusion body
Cellular Component	GO:0031965	nuclear membrane
Cellular Component	GO:0034399	nuclear periphery
Cellular Component	GO:0005643	nuclear pore
Cellular Component	GO:0044614	nuclear pore cytoplasmic filaments
Cellular Component	GO:0044615	nuclear pore nuclear basket
Cellular Component	GO:0031080	nuclear pore outer ring
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:1990904	ribonucleoprotein complex

InterPro / Pfam

InterPro	InterPro name
IPR007230	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain
IPR021967	Nuclear pore complex protein NUP96, C-terminal domain
IPR036903	Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily
IPR037665	Nucleoporin peptidase S59-like

Pfam	Pfam name
PF04096	Nucleoporin autopeptidase
PF12110	Nuclear protein 96

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1169408	ISG15 antiviral mechanism	Leaf	R-HSA-168256	Immune System
R-HSA-141444	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-159227	Transport of the SLBP independent Mature mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159230	Transport of the SLBP Dependant Mature mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159231	Transport of Mature mRNA Derived from an Intronless Transcript	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-159236	Transport of Mature mRNA derived from an Intron-Containing Transcript	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-165054	Rev-mediated nuclear export of HIV RNA	Leaf	R-HSA-1643685	Disease
R-HSA-168271	Transport of Ribonucleoproteins into the Host Nucleus	Leaf	R-HSA-1643685	Disease
R-HSA-168276	NS1 Mediated Effects on Host Pathways	Internal node	R-HSA-1643685	Disease
R-HSA-168325	Viral Messenger RNA Synthesis	Leaf	R-HSA-1643685	Disease
R-HSA-168333	NEP/NS2 Interacts with the Cellular Export Machinery	Leaf	R-HSA-1643685	Disease
R-HSA-170822	Regulation of Glucokinase by Glucokinase Regulatory Protein	Leaf	R-HSA-1430728	Metabolism
R-HSA-180746	Nuclear import of Rev protein	Leaf	R-HSA-1643685	Disease
R-HSA-180910	Vpr-mediated nuclear import of PICs	Leaf	R-HSA-1643685	Disease
R-HSA-191859	snRNP Assembly	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-2467813	Separation of Sister Chromatids	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2500257	Resolution of Sister Chromatid Cohesion	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-3108214	SUMOylation of DNA damage response and repair proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3232142	SUMOylation of ubiquitinylation proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3301854	Nuclear Pore Complex (NPC) Disassembly	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-3371453	Regulation of HSF1-mediated heat shock response	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-4085377	SUMOylation of SUMOylation proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4551638	SUMOylation of chromatin organization proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4570464	SUMOylation of RNA binding proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4615885	SUMOylation of DNA replication proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5578749	Transcriptional regulation by small RNAs	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-5619107	Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	Leaf	R-HSA-1643685	Disease
R-HSA-5663220	RHO GTPases Activate Formins	Leaf	R-HSA-162582	Signal Transduction
R-HSA-6784531	tRNA processing in the nucleus	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-68877	Mitotic Prometaphase	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-9609690	HCMV Early Events	Leaf	R-HSA-1643685	Disease
R-HSA-9610379	HCMV Late Events	Leaf	R-HSA-1643685	Disease
R-HSA-9615933	Postmitotic nuclear pore complex (NPC) reformation	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9648025	EML4 and NUDC in mitotic spindle formation	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Nucleus membrane	ECO:0000269	PubMed:10087256
Nucleus membrane	ECO:0000269	PubMed:11106761
Nucleus membrane	ECO:0000269	PubMed:11839768
Nucleus membrane	ECO:0000269	PubMed:12191480
Nucleus membrane	ECO:0000269	PubMed:12802065
Nucleus membrane	ECO:0000269	PubMed:15229283
Nucleus membrane	ECO:0000269	PubMed:20407419
Nucleus membrane	ECO:0000269	PubMed:28221134
Nucleus membrane	ECO:0000269	PubMed:33360543
Nucleus, nuclear pore complex	ECO:0000269	PubMed:11839768
Nucleus, nuclear pore complex	ECO:0000269	PubMed:12802065
Nucleus, nuclear pore complex	ECO:0000269	PubMed:15229283
Nucleus, nuclear pore complex	ECO:0000269	PubMed:33097660
Nucleus, nucleoplasm	ECO:0000269	PubMed:12191480
Nucleus, nucleoplasm	ECO:0000269	PubMed:28221134

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P52948

Gene: NUP98, ADAR2
Protein: Nuclear pore complex protein Nup98-Nup96

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P52948

Gene: NUP98, ADAR2 Protein: Nuclear pore complex protein Nup98-Nup96

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: NUP98, ADAR2
Protein: Nuclear pore complex protein Nup98-Nup96