Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0051642 | centrosome localization |
| Biological Process | GO:0006879 | intracellular iron ion homeostasis |
| Biological Process | GO:0016226 | iron-sulfur cluster assembly |
| Biological Process | GO:0010826 | negative regulation of centrosome duplication |
| Biological Process | GO:0072697 | protein localization to cell cortex |
| Biological Process | GO:0001558 | regulation of cell growth |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0140663 | ATP-dependent FeS chaperone activity |
| Molecular Function | GO:0051536 | iron-sulfur cluster binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0000166 | nucleotide binding |
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000808 | Mrp, conserved site |
| IPR003593 | AAA+ ATPase domain |
| IPR019591 | Mrp/NBP35 ATP-binding protein |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR028601 | Cytosolic Fe-S cluster assembly factor NUBP1/Nbp35 |
| IPR033756 | Flagellum site-determining protein YlxH/ Fe-S cluster assembling factor NBP35 |
| Pfam
|
Pfam name |
|---|---|
| PF10609 | NUBPL iron-transfer P-loop NTPase |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2564830 | Cytosolic iron-sulfur cluster assembly | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell projection | ECO:0000250 | |
| Cytoplasm | ECO:0000255 | PubMed:18573874 |
| Cytoplasm | ECO:0000255 | PubMed:29848660 |
| Cytoplasm, cytoskeleton, cilium axoneme | ECO:0000250 | |
| Cytoplasm, cytoskeleton, cilium basal body | ECO:0000250 | |
| Cytoplasm, cytoskeleton, microtubule organizing center | ECO:0000250 | |
| Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | ||
| Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole | ECO:0000250 | |
| Nucleus | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | glandular cells | Medium | Enhanced |
| appendix | lymphoid tissue | Medium | Enhanced |
| bone marrow | hematopoietic cells | Low | Enhanced |
| breast | glandular cells | Low | Enhanced |
| breast | myoepithelial cells | Low | Enhanced |
| bronchus | respiratory epithelial cells | Medium | Enhanced |
| caudate | glial cells | Medium | Enhanced |
| caudate | neuronal cells | Low | Enhanced |
| cerebellum | Purkinje cells | Low | Enhanced |
| cerebellum | cells in granular layer | Low | Enhanced |
| cerebral cortex | endothelial cells | Low | Enhanced |
| cerebral cortex | glial cells | Medium | Enhanced |
| cerebral cortex | neuropil | Medium | Enhanced |
| cervix | glandular cells | Low | Enhanced |
| cervix | squamous epithelial cells | Low | Enhanced |
| colon | endothelial cells | Low | Enhanced |
| colon | glandular cells | Medium | Enhanced |
| colon | peripheral nerve/ganglion | Medium | Enhanced |
| duodenum | glandular cells | Medium | Enhanced |
| endometrium 1 | glandular cells | Low | Enhanced |
| endometrium 2 | glandular cells | Medium | Enhanced |
| epididymis | glandular cells | Medium | Enhanced |
| esophagus | squamous epithelial cells | Low | Enhanced |
| fallopian tube | glandular cells | High | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| heart muscle | cardiomyocytes | Medium | Enhanced |
| hippocampus | glial cells | Medium | Enhanced |
| kidney | cells in glomeruli | Low | Enhanced |
| kidney | cells in tubules | High | Enhanced |
| liver | cholangiocytes | Low | Enhanced |
| liver | hepatocytes | Medium | Enhanced |
| lung | alveolar cells type II | Low | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | germinal center cells | Medium | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Medium | Enhanced |
| pancreas | pancreatic endocrine cells | Low | Enhanced |
| parathyroid gland | glandular cells | Low | Enhanced |
| placenta | trophoblastic cells | Medium | Enhanced |
| prostate | glandular cells | Low | Enhanced |
| rectum | glandular cells | Medium | Enhanced |
| salivary gland | glandular cells | Low | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Medium | Enhanced |
| skin 1 | endothelial cells | Low | Enhanced |
| skin 1 | fibrohistiocytic cells | Low | Enhanced |
| skin 1 | lymphocytes | Low | Enhanced |
| skin 1 | melanocytes | Low | Enhanced |
| skin 2 | cells in basal layer | Low | Enhanced |
| skin 2 | endothelial cells | Low | Enhanced |
| skin 2 | fibrohistiocytic cells | Low | Enhanced |
| skin 2 | lymphocytes | Medium | Enhanced |
| skin 2 | melanocytes | Low | Enhanced |
| small intestine | glandular cells | Medium | Enhanced |
| smooth muscle | smooth muscle cells | Medium | Enhanced |
| soft tissue 1 | fibroblasts | Low | Enhanced |
| soft tissue 1 | peripheral nerve | Medium | Enhanced |
| spleen | cells in red pulp | Low | Enhanced |
| spleen | cells in white pulp | Medium | Enhanced |
| stomach 1 | glandular cells | Medium | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| testis | Leydig cells | Low | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | Medium | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| vagina | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|