MultifacetedProtDB - Bologna Biocomputing Group

GO ontology	GO term	GO description
Biological Process	GO:0009653	anatomical structure morphogenesis
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0000278	mitotic cell cycle
Biological Process	GO:0046326	positive regulation of glucose import
Biological Process	GO:0006898	receptor-mediated endocytosis
Biological Process	GO:0042147	retrograde transport, endosome to Golgi
Molecular Function	GO:0032051	clathrin light chain binding
Molecular Function	GO:0005198	structural molecule activity
Cellular Component	GO:0030130	clathrin coat of trans-Golgi network vesicle
Cellular Component	GO:0071439	clathrin complex
Cellular Component	GO:0045334	clathrin-coated endocytic vesicle
Cellular Component	GO:0005905	clathrin-coated pit
Cellular Component	GO:0030136	clathrin-coated vesicle
Cellular Component	GO:0030135	coated vesicle
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005770	late endosome
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0097443	sorting endosome
Cellular Component	GO:0005819	spindle
Cellular Component	GO:0005802	trans-Golgi network

InterPro	InterPro name
IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat
IPR011990	Tetratricopeptide-like helical domain superfamily
IPR015348	Clathrin, heavy chain, linker, core motif
IPR016024	Armadillo-type fold
IPR016025	Clathrin heavy chain, N-terminal
IPR016341	Clathrin, heavy chain
IPR022365	Clathrin, heavy chain, propeller repeat

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-190873	Gap junction degradation	Internal node	R-HSA-5653656	Vesicle-mediated transport
R-HSA-196025	Formation of annular gap junctions	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-3928665	EPH-ephrin mediated repulsion of cells	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-8856828	Clathrin-mediated endocytosis	Internal node	R-HSA-5653656	Vesicle-mediated transport

Location	ECO term	Pubmed
Cytoplasmic vesicle membrane	ECO:0000250
Membrane, coated pit	ECO:0000250

HPO ID	HPO name
HP:0000324	Facial asymmetry
HP:0000347	Micrognathia
HP:0000448	Prominent nose
HP:0000486	Strabismus
HP:0000491	Keratitis
HP:0000742	Self-mutilation
HP:0001328	Specific learning disability
HP:0001518	Small for gestational age
HP:0001562	Oligohydramnios
HP:0001772	Talipes equinovalgus
HP:0001838	Rocker bottom foot
HP:0001999	Abnormal facial shape
HP:0002069	Bilateral tonic-clonic seizure
HP:0002188	Delayed CNS myelination
HP:0002754	Osteomyelitis
HP:0002757	Recurrent fractures
HP:0002982	Tibial bowing
HP:0007021	Pain insensitivity
HP:0008000	Decreased corneal reflex
HP:0008780	Congenital bilateral hip dislocation
HP:0008947	Infantile muscular hypotonia
HP:0009826	Limb undergrowth
HP:0010830	Impaired tactile sensation
HP:0010841	Multifocal epileptiform discharges
HP:0011344	Severe global developmental delay
HP:0011470	Nasogastric tube feeding in infancy
HP:0012044	Seesaw nystagmus
HP:0012745	Short palpebral fissure
HP:0200020	Corneal erosion

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Enhanced
bronchus	respiratory epithelial cells	Low	Enhanced
fallopian tube	glandular cells	Low	Enhanced
kidney	cells in tubules	Low	Enhanced
nasopharynx	respiratory epithelial cells	Low	Enhanced
skin 1	keratinocytes	Low	Enhanced
testis	pachytene spermatocytes	High	Enhanced
testis	preleptotene spermatocytes	Medium	Enhanced
testis	round or early spermatids	High	Enhanced
thyroid gland	glandular cells	Low	Enhanced