Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.3.1.-
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups;
3.1.1.32
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
phospholipase A1
3.1.1.4
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases;
phospholipase A2
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2KYT | Solution structure of the H-REV107 N-terminal domain | |
| 4DOT | 1.96 | Crystal structure of human HRASLS3. |
| 4FA0 | 2.65 | Crystal structure of human AdPLA to 2.65 A resolution |
| 4Q95 | 2.2 | Crystal structure of HRASLS3/LRAT chimeric protein |
| 7C3Z | 1.957 | The structure of class II tumor suppressor protein H-REV107 |
| 7C41 | 2.276 | KRAS G12V and H-REV107 peptide complex |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0070292 | N-acylphosphatidylethanolamine metabolic process |
| Biological Process | GO:0046485 | ether lipid metabolic process |
| Biological Process | GO:0070306 | lens fiber cell differentiation |
| Biological Process | GO:0016042 | lipid catabolic process |
| Biological Process | GO:0051179 | localization |
| Biological Process | GO:0030397 | membrane disassembly |
| Biological Process | GO:1903008 | organelle disassembly |
| Biological Process | GO:0007031 | peroxisome organization |
| Biological Process | GO:0036152 | phosphatidylethanolamine acyl-chain remodeling |
| Biological Process | GO:0008654 | phospholipid biosynthetic process |
| Biological Process | GO:0006644 | phospholipid metabolic process |
| Biological Process | GO:1904177 | regulation of adipose tissue development |
| Biological Process | GO:0009617 | response to bacterium |
| Biological Process | GO:0006641 | triglyceride metabolic process |
| Molecular Function | GO:0052740 | 1-acyl-2-lysophosphatidylserine acylhydrolase activity |
| Molecular Function | GO:0016410 | N-acyltransferase activity |
| Molecular Function | GO:0016746 | acyltransferase activity |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0052739 | phosphatidylserine 1-acylhydrolase activity |
| Molecular Function | GO:0008970 | phospholipase A1 activity |
| Molecular Function | GO:0004623 | phospholipase A2 activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0031966 | mitochondrial membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005635 | nuclear envelope |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005778 | peroxisomal membrane |
| Cellular Component | GO:0005777 | peroxisome |
| Cellular Component | GO:0005886 | plasma membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1482788 | Acyl chain remodelling of PC | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482801 | Acyl chain remodelling of PS | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482839 | Acyl chain remodelling of PE | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-1482922 | Acyl chain remodelling of PI | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000250 | |
| Cytoplasm | ECO:0000269 | PubMed:17374643 |
| Cytoplasm, cytosol | ECO:0000250 | |
| Cytoplasm, perinuclear region | ECO:0000250 | |
| Endoplasmic reticulum membrane | ECO:0000250 | |
| Lysosome membrane | ECO:0000250 | |
| Mitochondrion membrane | ECO:0000250 | |
| Nucleus envelope | ECO:0000250 | |
| Peroxisome membrane | ECO:0000250 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | Low | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | glandular cells | Low | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | neuronal cells | Medium | Approved |
| cerebellum | Purkinje cells | Low | Approved |
| cerebellum | cells in granular layer | Medium | Approved |
| cerebral cortex | neuronal cells | Medium | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Low | Approved |
| colon | glandular cells | High | Approved |
| colon | peripheral nerve/ganglion | High | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | Medium | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | Medium | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | Medium | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | neuronal cells | Medium | Approved |
| kidney | cells in tubules | High | Approved |
| liver | cholangiocytes | Low | Approved |
| liver | hepatocytes | Medium | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | High | Approved |
| oral mucosa | squamous epithelial cells | Low | Approved |
| ovary | follicle cells | Medium | Approved |
| pancreas | exocrine glandular cells | Low | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | decidual cells | Low | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Low | Approved |
| seminal vesicle | glandular cells | Medium | Approved |
| skin 1 | keratinocytes | Low | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Medium | Approved |
| small intestine | glandular cells | High | Approved |
| spleen | cells in red pulp | Low | Approved |
| stomach 1 | glandular cells | Medium | Approved |
| stomach 2 | glandular cells | Medium | Approved |
| testis | elongated or late spermatids | High | Approved |
| testis | pachytene spermatocytes | High | Approved |
| testis | round or early spermatids | High | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| urinary bladder | urothelial cells | High | Approved |
| vagina | squamous epithelial cells | Medium | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|