Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
6.1.1.1
Ligases;
Forming carbon-oxygen bonds;
Ligases forming aminoacyl-tRNA and related compounds;
tyrosine—tRNA ligase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1N3L | 1.18 | Crystal structure of a human aminoacyl-tRNA synthetase cytokine |
| 1NTG | 2.21 | Crystal Structure of the EMAP II-like Cytokine Released from human tyrosyl-tRNA Synthetase |
| 1Q11 | 1.6 | Crystal structure of an active fragment of human tyrosyl-tRNA synthetase with tyrosinol |
| 4Q93 | 2.1 | Crystal structure of resveratrol bound human tyrosyl tRNA synthetase |
| 4QBT | 2.1 | Crystal structure of tyrosine bound human tyrosyl tRNA synthetase |
| 5THH | 1.959 | Crystal structure of a human tyrosyl-tRNA synthetase mutant |
| 5THL | 1.6 | Crystal structure of the human tyrosyl-tRNA synthetase mutant G41R |
| 7ROU | 1.7 | Structure of human tyrosyl tRNA synthetase in complex with ML901-Tyr |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0042594 | response to starvation |
| Biological Process | GO:0006437 | tyrosyl-tRNA aminoacylation |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0005153 | interleukin-8 receptor binding |
| Molecular Function | GO:1905594 | resveratrol binding |
| Molecular Function | GO:0036094 | small molecule binding |
| Molecular Function | GO:0000049 | tRNA binding |
| Molecular Function | GO:0004831 | tyrosine-tRNA ligase activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
| IPR002307 | Tyrosine-tRNA ligase |
| IPR002547 | tRNA-binding domain |
| IPR012340 | Nucleic acid-binding, OB-fold |
| IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
| Pfam
|
Pfam name |
|---|---|
| PF00579 | tRNA synthetases class I (W and Y) |
| PF01588 | Putative tRNA binding domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-379716 | Cytosolic tRNA aminoacylation | Leaf | R-HSA-392499 | Metabolism of proteins |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000305 | PubMed:16429158 |
| Cytoplasm | ECO:0000305 | PubMed:30304524 |
| Cytoplasm | ECO:0000305 | PubMed:9162081 |
| Nucleus | ECO:0000269 | PubMed:22291016 |
| Nucleus | ECO:0000269 | PubMed:25533949 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000218 | High palate |
| HP:0000252 | Microcephaly |
| HP:0000286 | Epicanthus |
| HP:0000293 | Full cheeks |
| HP:0000308 | Microretrognathia |
| HP:0000431 | Wide nasal bridge |
| HP:0000490 | Deeply set eye |
| HP:0000639 | Nystagmus |
| HP:0000662 | Nyctalopia |
| HP:0000786 | Primary amenorrhea |
| HP:0001133 | Constriction of peripheral visual field |
| HP:0001252 | Hypotonia |
| HP:0001274 | Agenesis of corpus callosum |
| HP:0001284 | Areflexia |
| HP:0001382 | Joint hypermobility |
| HP:0001394 | Cirrhosis |
| HP:0001397 | Hepatic steatosis |
| HP:0001414 | Microvesicular hepatic steatosis |
| HP:0001508 | Failure to thrive |
| HP:0001510 | Growth delay |
| HP:0001531 | Failure to thrive in infancy |
| HP:0001622 | Premature birth |
| HP:0001629 | Ventricular septal defect |
| HP:0001738 | Exocrine pancreatic insufficiency |
| HP:0001744 | Splenomegaly |
| HP:0001747 | Accessory spleen |
| HP:0001748 | Polysplenia |
| HP:0001760 | Abnormal foot morphology |
| HP:0001903 | Anemia |
| HP:0001943 | Hypoglycemia |
| HP:0001998 | Neonatal hypoglycemia |
| HP:0002013 | Vomiting |
| HP:0002079 | Hypoplasia of the corpus callosum |
| HP:0002119 | Ventriculomegaly |
| HP:0002151 | Increased serum lactate |
| HP:0002155 | Hypertriglyceridemia |
| HP:0002194 | Delayed gross motor development |
| HP:0002197 | Generalized-onset seizure |
| HP:0002240 | Hepatomegaly |
| HP:0002355 | Difficulty walking |
| HP:0002460 | Distal muscle weakness |
| HP:0002474 | Expressive language delay |
| HP:0002611 | Cholestatic liver disease |
| HP:0002716 | Lymphadenopathy |
| HP:0002936 | Distal sensory impairment |
| HP:0003383 | Onion bulb formation |
| HP:0003431 | Decreased motor nerve conduction velocity |
| HP:0003448 | Decreased sensory nerve conduction velocity |
| HP:0003450 | Axonal regeneration |
| HP:0003484 | Upper limb muscle weakness |
| HP:0003593 | Infantile onset |
| HP:0003693 | Distal amyotrophy |
| HP:0005280 | Depressed nasal bridge |
| HP:0005948 | Multiple pulmonary cysts |
| HP:0006577 | Macronodular cirrhosis |
| HP:0006579 | Prolonged neonatal jaundice |
| HP:0007401 | Macular atrophy |
| HP:0008619 | Bilateral sensorineural hearing impairment |
| HP:0009046 | Difficulty running |
| HP:0011232 | Infra-orbital fold |
| HP:0012715 | Profound hearing impairment |
| HP:0025709 | Intermediate young adult onset |
| HP:0030237 | Hand muscle weakness |
| HP:0030319 | Weakness of facial musculature |
| HP:0033454 | Tube feeding |
| HP:0100806 | Sepsis |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| charcot-marie-tooth disease dominant intermediate c | MONDO:0012012 | G60 | chapter6, Diseases of the nervous system | OMIM:608323 | Orphanet:100045 |