MultifacetedProtDB - Bologna Biocomputing Group

Summary of P54687

Gene: BCAT1, BCT1, ECA39
Protein: Branched-chain-amino-acid aminotransferase, cytosolic

Protein family
Protein sequence
Protein function

Catalytic activity

EC number	EC number description
2.6.1.42	Transferases; Transferring nitrogenous groups; Transaminases; branched-chain-amino-acid transaminase

Publications

Structure

Link to AlphaFold model

PDB	Resolution (Å)	PDB name
2ABJ	2.2	Crystal structure of human branched chain amino acid transaminase in a complex with an inhibitor, C16H10N2O4F3SCl, and pyridoxal 5' phosphate.
2COG	2.1	Crystal structure of oxidized human cytosolic branched-chain aminotransferase complexed with 4-methylvalerate
2COI	1.9	Crystal structure of oxidized human cytosolic branched-chain aminotransferase complexed with gabapentin
2COJ	2.4	Crystal structure of reduced human cytosolic branched-chain aminotransferase complexed with gabapentin
7NTR	2.23	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SUBSTRATE MIMIC 3-PHENYLPROPIONATE
7NWA	1.59	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND COMPOUND A
7NWB	2.64	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND INHIBITOR COMPOUND 1
7NWC	2.38	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND INHIBITOR COMPOUND 2
7NWE	2.54	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND INHIBITOR COMPOUND 10
7NWM	2.15	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND INHIBITOR COMPOUND 12
7NXN	1.7	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR COMPOUND 21(5-F)
7NXO	1.71	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR COMPOUND 24(5-F)
7NY2	2.31	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR COMPOUND 35
7NY9	1.6	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR COMPOUND 38
7NYA	1.85	CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC BRANCHED-CHAIN AMINOTRANSFERASE (BCAT1) IN COMPLEX WITH PLP AND SMALL MOLECULE INHIBITOR BAY-069 (COMPOUND 36)

GO term

GO ontology	GO term	GO description
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle
Biological Process	GO:0009082	branched-chain amino acid biosynthetic process
Biological Process	GO:0009098	leucine biosynthetic process
Biological Process	GO:0006629	lipid metabolic process
Biological Process	GO:0009099	valine biosynthetic process
Molecular Function	GO:0052656	L-isoleucine transaminase activity
Molecular Function	GO:0052654	L-leucine transaminase activity
Molecular Function	GO:0050048	L-leucine:2-oxoglutarate aminotransferase activity
Molecular Function	GO:0052655	L-valine transaminase activity
Molecular Function	GO:0004084	branched-chain-amino-acid transaminase activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005739	mitochondrion

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease