Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
6.1.1.10
Ligases;
Forming carbon-oxygen bonds;
Ligases forming aminoacyl-tRNA and related compounds;
methionine—tRNA ligase
PDB | Resolution (Å) | PDB name |
---|---|---|
2DJV | Solution structures of the WHEP-TRS domain of human methionyl-tRNA synthetase | |
4BL7 | 1.892 | Crystal structure of the AIMP3-MRS N-terminal domain complex in different space group |
4BVX | 1.6 | Crystal structure of the AIMP3-MRS N-terminal domain complex with I3C |
4BVY | 1.992 | Crystal structure of the AIMP3-MRS N-terminal domain complex |
5GL7 | 2.013 | Crystal structure of a truncated human cytosolic methionyl-tRNA synthetase |
5GOY | 2.278 | The crystal structure of human cytosolic methionyl-tRNA synthetase in complex with methionine |
5Y6L | 2.9 | A subcomplex crystal structure of human cytosolic aspartyl-tRNA synthetase and heterotetrameric glutathione transferase-homology domains in multi-tRNA synthetase complex |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
Biological Process | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
Biological Process | GO:0006431 | methionyl-tRNA aminoacylation |
Biological Process | GO:1901838 | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I |
Biological Process | GO:0009303 | rRNA transcription |
Biological Process | GO:0006418 | tRNA aminoacylation for protein translation |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0004825 | methionine-tRNA ligase activity |
Molecular Function | GO:0000049 | tRNA binding |
Cellular Component | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005730 | nucleolus |
InterPro | InterPro name |
---|---|
IPR000738 | WHEP-TRS domain |
IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
IPR004046 | Glutathione S-transferase, C-terminal |
IPR009068 | S15/NS1, RNA-binding |
IPR009080 | Aminoacyl-tRNA synthetase, class Ia, anticodon-binding |
IPR010987 | Glutathione S-transferase, C-terminal-like |
IPR014729 | Rossmann-like alpha/beta/alpha sandwich fold |
IPR014758 | Methionyl-tRNA synthetase |
IPR015413 | Methionyl/Leucyl tRNA synthetase |
IPR023458 | Methionine-tRNA ligase, type 1 |
IPR029038 | Methionyl-tRNA synthetase, Zn-domain |
IPR033911 | Methioninyl-tRNA synthetase core domain |
IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
IPR041598 | Methionine--tRNA ligase, N-terminal |
IPR041872 | Methionyl-tRNA synthetase, anticodon-binding domain |
Pfam | Pfam name |
---|---|
PF00043 | Glutathione S-transferase, C-terminal domain |
PF00458 | WHEP-TRS domain |
PF09334 | tRNA synthetases class I (M) |
PF18485 | Glutathione S-transferase, N-terminal domain |
PF19303 | Anticodon binding domain of methionyl tRNA ligase |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-2408522 | Selenoamino acid metabolism | Internal node | R-HSA-1430728 | Metabolism |
R-HSA-379716 | Cytosolic tRNA aminoacylation | Leaf | R-HSA-392499 | Metabolism of proteins |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm, cytosol | ECO:0000305 | PubMed:10791971 |
Cytoplasm, cytosol | ECO:0000305 | PubMed:19289464 |
Cytoplasm, cytosol | ECO:0000305 | PubMed:26472928 |
Nucleus, nucleolus | ECO:0000269 | PubMed:10791971 |
HPO ID | HPO name |
---|---|
HP:0000006 | Autosomal dominant inheritance |
HP:0000007 | Autosomal recessive inheritance |
HP:0000100 | Nephrotic syndrome |
HP:0000286 | Epicanthus |
HP:0000689 | Dental malocclusion |
HP:0000821 | Hypothyroidism |
HP:0001156 | Brachydactyly |
HP:0001217 | Clubbing |
HP:0001249 | Intellectual disability |
HP:0001251 | Ataxia |
HP:0001252 | Hypotonia |
HP:0001256 | Intellectual disability, mild |
HP:0001263 | Global developmental delay |
HP:0001270 | Motor delay |
HP:0001284 | Areflexia |
HP:0001288 | Gait disturbance |
HP:0001315 | Reduced tendon reflexes |
HP:0001388 | Joint laxity |
HP:0001394 | Cirrhosis |
HP:0001395 | Hepatic fibrosis |
HP:0001396 | Cholestasis |
HP:0001397 | Hepatic steatosis |
HP:0001399 | Hepatic failure |
HP:0001508 | Failure to thrive |
HP:0001894 | Thrombocytosis |
HP:0001903 | Anemia |
HP:0001987 | Hyperammonemia |
HP:0002013 | Vomiting |
HP:0002061 | Lower limb spasticity |
HP:0002093 | Respiratory insufficiency |
HP:0002094 | Dyspnea |
HP:0002206 | Pulmonary fibrosis |
HP:0002240 | Hepatomegaly |
HP:0002355 | Difficulty walking |
HP:0002378 | Hand tremor |
HP:0002460 | Distal muscle weakness |
HP:0002705 | High, narrow palate |
HP:0002936 | Distal sensory impairment |
HP:0003128 | Lactic acidosis |
HP:0003355 | Aminoaciduria |
HP:0003376 | Steppage gait |
HP:0003477 | Peripheral axonal neuropathy |
HP:0003584 | Late onset |
HP:0003593 | Infantile onset |
HP:0003596 | Middle age onset |
HP:0003623 | Neonatal onset |
HP:0003676 | Progressive |
HP:0003677 | Slowly progressive |
HP:0003693 | Distal amyotrophy |
HP:0006517 | Intraalveolar phospholipid accumulation |
HP:0006530 | Abnormal pulmonary interstitial morphology |
HP:0007020 | Progressive spastic paraplegia |
HP:0008064 | Ichthyosis |
HP:0008070 | Sparse hair |
HP:0008404 | Nail dystrophy |
HP:0009027 | Foot dorsiflexor weakness |
HP:0009130 | Hand muscle atrophy |
HP:0009830 | Peripheral neuropathy |
HP:0011463 | Childhood onset |
HP:0012418 | Hypoxemia |
HP:0012447 | Abnormal myelination |
HP:0012735 | Cough |
HP:0030237 | Hand muscle weakness |
HP:0030948 | Elevated gamma-glutamyltransferase level |
HP:0031956 | Elevated circulating aspartate aminotransferase concentration |
HP:0031964 | Elevated circulating alanine aminotransferase concentration |
HP:0032152 | Keratosis pilaris |
HP:0045055 | Tiger tail banding |
HP:0045075 | Sparse eyebrow |
HP:0100022 | Abnormality of movement |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
severe early-onset pulmonary alveolar proteinosis due to mars deficiency | MONDO:0014206 | J84 | chapter10, Diseases of the respiratory system | OMIM:615486 | Orphanet:370088 |
severe early-onset pulmonary alveolar proteinosis due to mars deficiency | MONDO:0014206 | J84 | chapter10, Diseases of the respiratory system | OMIM:615486 | Orphanet:440427 |
charcot-marie-tooth disease axonal type 2u | MONDO:0014566 | G60 | chapter6, Diseases of the nervous system | OMIM:616280 | Orphanet:397735 |
autosomal recessive spastic paraplegia type 70 | MONDO:0018422 | G11 | chapter6, Diseases of the nervous system | Orphanet:401835 |