MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.4.3.-	Oxidoreductases; Acting on the CH-NH2 group of donors; With oxygen as acceptor;
1.4.3.13	Oxidoreductases; Acting on the CH-NH2 group of donors; With oxygen as acceptor; protein-lysine 6-oxidase

GO ontology	GO term	GO description
Biological Process	GO:0030199	collagen fibril organization
Biological Process	GO:0001837	epithelial to mesenchymal transition
Biological Process	GO:1905590	fibronectin fibril organization
Biological Process	GO:0006954	inflammatory response
Biological Process	GO:0030324	lung development
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:2000329	negative regulation of T-helper 17 cell lineage commitment
Biological Process	GO:0018057	peptidyl-lysine oxidation
Biological Process	GO:2001046	positive regulation of integrin-mediated signaling pathway
Biological Process	GO:0060021	roof of mouth development
Biological Process	GO:0061053	somite development
Biological Process	GO:0021510	spinal cord development
Molecular Function	GO:0005507	copper ion binding
Molecular Function	GO:0001968	fibronectin binding
Molecular Function	GO:0004720	protein-lysine 6-oxidase activity
Molecular Function	GO:0005044	scavenger receptor activity
Cellular Component	GO:0062023	collagen-containing extracellular matrix
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus

InterPro	InterPro name
IPR001190	SRCR domain
IPR001695	Lysyl oxidase
IPR017448	SRCR-like domain
IPR019828	Lysyl oxidase, conserved site
IPR036772	SRCR-like domain superfamily

Pfam	Pfam name
PF00530	Scavenger receptor cysteine-rich domain
PF01186	Lysyl oxidase

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1566948	Elastic fibre formation	Internal node	R-HSA-1474244	Extracellular matrix organization
R-HSA-2243919	Crosslinking of collagen fibrils	Leaf	R-HSA-1474244	Extracellular matrix organization

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:17018530
Cytoplasm	ECO:0000269	PubMed:28065600
Nucleus	ECO:0000269	PubMed:28065600
Secreted, extracellular space	ECO:0000250
Secreted, extracellular space	ECO:0000269	PubMed:17018530
Secreted, extracellular space	ECO:0000305

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000175	Cleft palate
HP:0000272	Malar flattening
HP:0000347	Micrognathia
HP:0000407	Sensorineural hearing impairment
HP:0000483	Astigmatism
HP:0000518	Cataract
HP:0000541	Retinal detachment
HP:0000545	Myopia
HP:0000646	Amblyopia
HP:0000926	Platyspondyly
HP:0002656	Epiphyseal dysplasia
HP:0002857	Genu valgum
HP:0003301	Irregular vertebral endplates
HP:0004322	Short stature
HP:0005692	Joint hyperflexibility
HP:0005930	Abnormal epiphysis morphology
HP:0007773	Vitreoretinopathy
HP:0011003	High myopia
HP:0011463	Childhood onset
HP:0012368	Flat face

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
bronchus	respiratory epithelial cells	Low	Approved
cerebral cortex	neuropil	Low	Approved
colon	glandular cells	Medium	Approved
duodenum	glandular cells	High	Approved
epididymis	glandular cells	Low	Approved
gallbladder	glandular cells	Medium	Approved
kidney	cells in tubules	Medium	Approved
liver	hepatocytes	Low	Approved
lung	macrophages	Medium	Approved
nasopharynx	respiratory epithelial cells	Low	Approved
oral mucosa	squamous epithelial cells	Low	Approved
pancreas	exocrine glandular cells	High	Approved
placenta	decidual cells	High	Approved
prostate	glandular cells	Low	Approved
rectum	glandular cells	Low	Approved
salivary gland	glandular cells	Medium	Approved
small intestine	glandular cells	High	Approved
stomach 1	glandular cells	Low	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Low	Approved
tonsil	squamous epithelial cells	Low	Approved
urinary bladder	urothelial cells	Low	Approved