MultifacetedProtDB - Bologna Biocomputing Group

PDB	Resolution (Å)	PDB name
2KHT		NMR Structure of human alpha defensin HNP-1
2PM1	1.6	Derivative of human alpha-defensin 1 (HNP1)
3GNY	1.56	Crystal structure of human alpha-defensin 1 (HNP1)
3H6C	1.63	Crystal structure of human alpha-defensin 1 (Mutant Gln22Ala)
3HJ2	1.4	Crystal structure of covalent dimer of HNP1
3HJD	1.65	X-ray structure of monomeric variant of HNP1
3LO1	1.6	Crystal structure of human alpha-defensin 1 (Y16A mutant)
3LO2	1.56	Crystal structure of human alpha-defensin 1 (Y21A mutant)
3LO4	1.75	Crystal structure of human alpha-defensin 1 (R24A mutant)
3LO6	1.56	Crystal structure of human alpha-defensin 1 (W26Aba mutant)
3LO9	1.56	Crystal structure of human alpha-defensin 1 (W26Ahp mutant)
3LOE	1.56	Crystal structure of human alpha-defensin 1 (F28A mutant)
3LVX	1.63	Crystal structure of human alpha-defensin 1 (I6A mutant)
4DU0	1.9	Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant)
4LB1	2.0	Crystal structure of human alpha-defensin 1 (HNP1) Y16A/F28A mutant
4LB7	1.902	Crystal structure of human alpha-defensin 1 (HNP1) Y16A/I20A/L25A/F28A mutant.
4LBB	1.719	Crystal structure of human alpha-defensin 1 (HNP1) I20A mutant
4LBF	1.7	Crystal structure of HUMAN ALPHA-DEFENSIN 1 (HNP1) I20A/L25A mutant

GO ontology	GO term	GO description
Biological Process	GO:0010818	T cell chemotaxis
Biological Process	GO:0019731	antibacterial humoral response
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process	GO:0071222	cellular response to lipopolysaccharide
Biological Process	GO:0006935	chemotaxis
Biological Process	GO:0050829	defense response to Gram-negative bacterium
Biological Process	GO:0050830	defense response to Gram-positive bacterium
Biological Process	GO:0050832	defense response to fungus
Biological Process	GO:0042832	defense response to protozoan
Biological Process	GO:0051607	defense response to virus
Biological Process	GO:0051673	disruption of membrane integrity in another organism
Biological Process	GO:0006955	immune response
Biological Process	GO:0002227	innate immune response in mucosa
Biological Process	GO:0030520	intracellular estrogen receptor signaling pathway
Biological Process	GO:0051873	killing by host of symbiont cells
Biological Process	GO:0031640	killing of cells of another organism
Molecular Function	GO:0140911	pore-forming activity
Cellular Component	GO:0005796	Golgi lumen
Cellular Component	GO:0035578	azurophil granule lumen
Cellular Component	GO:0062023	collagen-containing extracellular matrix
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005615	extracellular space

InterPro	InterPro name
IPR002366	Alpha-defensin, N-terminal
IPR006080	Beta/alpha-defensin, C-terminal
IPR006081	Alpha-defensin, C-terminal
IPR016327	Alpha-defensin

Pfam	Pfam name
PF00323	Mammalian defensin
PF00879	Defensin propeptide

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1461973	Defensins	Internal node	R-HSA-168256	Immune System
R-HSA-1462054	Alpha-defensins	Leaf	R-HSA-168256	Immune System
R-HSA-6798695	Neutrophil degranulation	Leaf	R-HSA-168256	Immune System

Tissue	Cell type	Expression level	Reliability
bone marrow	hematopoietic cells	High	Enhanced
bone marrow	hematopoietic cells	High	Supported
spleen	cells in red pulp	High	Enhanced
spleen	cells in red pulp	High	Supported