Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Catalytic activity
PDB | Resolution (Å) | PDB name |
---|---|---|
4UG0 | 3.6 | STRUCTURE OF THE HUMAN 80S RIBOSOME |
4V6X | 5.0 | Structure of the human 80S ribosome |
5A2Q | 3.9 | Structure of the HCV IRES bound to the human ribosome |
5AJ0 | 3.5 | Cryo electron microscopy of actively translating human polysomes (POST state). |
5FLX | 3.9 | Mammalian 40S HCV-IRES complex |
5LKS | 3.6 | Structure-function insights reveal the human ribosome as a cancer target for antibiotics |
5OA3 | 4.2 | Human 40S-eIF2D-re-initiation complex |
5T2C | 3.6 | CryoEM structure of the human ribosome at 3.6 Angstrom resolution |
5VYC | 6.0 | Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1. |
6FEC | 6.3 | Human cap-dependent 48S pre-initiation complex |
6G51 | 4.1 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State D |
6G53 | 4.5 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State E |
6G5H | 3.6 | Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature |
6G5I | 3.5 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State R |
6IP5 | 3.9 | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) |
6IP6 | 4.5 | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) |
6IP8 | 3.9 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) |
6OLE | 3.1 | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs |
6OLF | 3.9 | Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs |
6OLG | 3.4 | Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA) |
6OLI | 3.5 | Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC) |
6OLZ | 3.9 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA |
6OM0 | 3.1 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs |
6OM7 | 3.7 | Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs |
6QZP | 2.9 | High-resolution cryo-EM structure of the human 80S ribosome |
6XA1 | 2.8 | Structure of a drug-like compound stalled human translation termination complex |
6Y0G | 3.2 | Structure of human ribosome in classical-PRE state |
6Y2L | 3.0 | Structure of human ribosome in POST state |
6Y57 | 3.5 | Structure of human ribosome in hybrid-PRE state |
6YBS | 3.1 | Structure of a human 48S translational initiation complex - head |
6Z6L | 3.0 | Cryo-EM structure of human CCDC124 bound to 80S ribosomes |
6Z6M | 3.1 | Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1 |
6Z6N | 2.9 | Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1) |
6ZLW | 2.6 | SARS-CoV-2 Nsp1 bound to the human 40S ribosomal subunit |
6ZM7 | 2.7 | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex |
6ZME | 3.0 | SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex |
6ZMI | 2.6 | SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex |
6ZMO | 3.1 | SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex |
6ZMT | 3.0 | SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex |
6ZMW | 3.7 | Structure of a human 48S translational initiation complex |
6ZN5 | 3.2 | SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex - state 2 |
6ZOJ | 2.8 | SARS-CoV-2-Nsp1-40S complex, composite map |
6ZOL | 2.8 | SARS-CoV-2-Nsp1-40S complex, focused on head |
6ZON | 3.0 | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 |
6ZP4 | 2.9 | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2 |
6ZUO | 3.1 | Human RIO1(kd)-StHA late pre-40S particle, structural state A (pre 18S rRNA cleavage) |
6ZV6 | 2.9 | Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage) |
6ZVH | 2.9 | EDF1-ribosome complex |
6ZVJ | 3.8 | Structure of a human ABCE1-bound 43S pre-initiation complex - State II |
6ZXD | 3.2 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State F1 |
6ZXE | 3.0 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State F2 |
6ZXF | 3.7 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State G |
6ZXG | 2.6 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State H1 |
6ZXH | 2.7 | Cryo-EM structure of a late human pre-40S ribosomal subunit - State H2 |
7A09 | 3.5 | Structure of a human ABCE1-bound 43S pre-initiation complex - State III |
7K5I | 2.9 | SARS-COV-2 nsp1 in complex with human 40S ribosome |
7QP6 | 4.7 | Structure of the human 48S initiation complex in open state (h48S AUG open) |
7QP7 | 3.7 | Structure of the human 48S initiation complex in closed state (h48S AUG closed) |
7R4X | 2.15 | Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map |
7TQL | 3.2 | CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B. |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0002181 | cytoplasmic translation |
Biological Process | GO:1901798 | positive regulation of signal transduction by p53 class mediator |
Biological Process | GO:0006412 | translation |
Molecular Function | GO:0097371 | MDM2/MDM4 family protein binding |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0003735 | structural constituent of ribosome |
Molecular Function | GO:1990948 | ubiquitin ligase inhibitor activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0022626 | cytosolic ribosome |
Cellular Component | GO:0022627 | cytosolic small ribosomal subunit |
Cellular Component | GO:0070062 | extracellular exosome |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005654 | nucleoplasm |
Cellular Component | GO:0045202 | synapse |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-156902 | Peptide chain elongation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-192823 | Viral mRNA Translation | Leaf | R-HSA-1643685 | Disease |
R-HSA-2408557 | Selenocysteine synthesis | Leaf | R-HSA-1430728 | Metabolism |
R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-72649 | Translation initiation complex formation | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72689 | Formation of a pool of free 40S subunits | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72695 | Formation of the ternary complex, and subsequently, the 43S complex | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72702 | Ribosomal scanning and start codon recognition | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-72764 | Eukaryotic Translation Termination | Leaf | R-HSA-392499 | Metabolism of proteins |
R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Leaf | R-HSA-1266738 | Developmental Biology |
R-HSA-9633012 | Response of EIF2AK4 (GCN2) to amino acid deficiency | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | Leaf | R-HSA-1643685 | Disease |
R-HSA-9754678 | SARS-CoV-2 modulates host translation machinery | Leaf | R-HSA-1643685 | Disease |
R-HSA-975956 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) | Leaf | R-HSA-8953854 | Metabolism of RNA |
R-HSA-975957 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) | Leaf | R-HSA-8953854 | Metabolism of RNA |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000269 | PubMed:23636399 |
HPO ID | HPO name |
---|---|
HP:0000047 | Hypospadias |
HP:0000085 | Horseshoe kidney |
HP:0000104 | Renal agenesis |
HP:0000119 | Abnormality of the genitourinary system |
HP:0000185 | Cleft soft palate |
HP:0000218 | High palate |
HP:0000234 | Abnormality of the head |
HP:0000252 | Microcephaly |
HP:0000286 | Epicanthus |
HP:0000294 | Low anterior hairline |
HP:0000316 | Hypertelorism |
HP:0000347 | Micrognathia |
HP:0000369 | Low-set ears |
HP:0000431 | Wide nasal bridge |
HP:0000465 | Webbed neck |
HP:0000470 | Short neck |
HP:0000486 | Strabismus |
HP:0000505 | Visual impairment |
HP:0000508 | Ptosis |
HP:0000519 | Developmental cataract |
HP:0000708 | Atypical behavior |
HP:0000716 | Depression |
HP:0000737 | Irritability |
HP:0000738 | Hallucinations |
HP:0000739 | Anxiety |
HP:0000912 | Sprengel anomaly |
HP:0000980 | Pallor |
HP:0001087 | Developmental glaucoma |
HP:0001123 | Visual field defect |
HP:0001199 | Triphalangeal thumb |
HP:0001227 | Abnormality of the thenar eminence |
HP:0001250 | Seizure |
HP:0001252 | Hypotonia |
HP:0001254 | Lethargy |
HP:0001260 | Dysarthria |
HP:0001276 | Hypertonia |
HP:0001288 | Gait disturbance |
HP:0001371 | Flexion contracture |
HP:0001402 | Hepatocellular carcinoma |
HP:0001510 | Growth delay |
HP:0001518 | Small for gestational age |
HP:0001627 | Abnormal heart morphology |
HP:0001629 | Ventricular septal defect |
HP:0001631 | Atrial septal defect |
HP:0001680 | Coarctation of aorta |
HP:0001790 | Nonimmune hydrops fetalis |
HP:0001824 | Weight loss |
HP:0001873 | Thrombocytopenia |
HP:0001875 | Neutropenia |
HP:0001882 | Leukopenia |
HP:0001894 | Thrombocytosis |
HP:0001895 | Normochromic anemia |
HP:0001896 | Reticulocytopenia |
HP:0002017 | Nausea and vomiting |
HP:0002019 | Constipation |
HP:0002024 | Malabsorption |
HP:0002027 | Abdominal pain |
HP:0002076 | Migraine |
HP:0002167 | Abnormality of speech or vocalization |
HP:0002239 | Gastrointestinal hemorrhage |
HP:0002354 | Memory impairment |
HP:0002376 | Developmental regression |
HP:0002516 | Increased intracranial pressure |
HP:0002669 | Osteosarcoma |
HP:0002671 | Basal cell carcinoma |
HP:0002817 | Abnormality of the upper limb |
HP:0002863 | Myelodysplasia |
HP:0002893 | Pituitary adenoma |
HP:0002894 | Neoplasm of the pancreas |
HP:0003006 | Neuroblastoma |
HP:0003401 | Paresthesia |
HP:0004322 | Short stature |
HP:0004374 | Hemiplegia/hemiparesis |
HP:0004808 | Acute myeloid leukemia |
HP:0005280 | Depressed nasal bridge |
HP:0005518 | Increased mean corpuscular volume |
HP:0005532 | Macrocytic dyserythropoietic anemia |
HP:0006725 | Pancreatic adenocarcinoma |
HP:0006758 | Malignant genitourinary tract tumor |
HP:0007018 | Attention deficit hyperactivity disorder |
HP:0007256 | Abnormal pyramidal sign |
HP:0008551 | Microtia |
HP:0009726 | Renal neoplasm |
HP:0009777 | Absent thumb |
HP:0009778 | Short thumb |
HP:0009944 | Partial duplication of thumb phalanx |
HP:0010524 | Agnosia |
HP:0010526 | Dysgraphia |
HP:0010622 | Neoplasm of the skeletal system |
HP:0010784 | Uterine neoplasm |
HP:0010786 | Urinary tract neoplasm |
HP:0011904 | Persistence of hemoglobin F |
HP:0012113 | Abnormal circulating creatine concentration |
HP:0012126 | Stomach cancer |
HP:0012133 | Erythroid hypoplasia |
HP:0012174 | Glioblastoma multiforme |
HP:0012378 | Fatigue |
HP:0012410 | Pure red cell aplasia |
HP:0012758 | Neurodevelopmental delay |
HP:0020118 | Radial artery aplasia |
HP:0030270 | Elevated red cell adenosine deaminase level |
HP:0040276 | Adenocarcinoma of the colon |
HP:0100013 | Neoplasm of the breast |
HP:0100031 | Neoplasm of the thyroid gland |
HP:0100273 | Neoplasm of the colon |
HP:0100571 | Cardiac diverticulum |
HP:0100576 | Amaurosis fugax |
HP:0100615 | Ovarian neoplasm |
HP:0100660 | Dyskinesia |
HP:0100743 | Neoplasm of the rectum |
HP:0100835 | Benign neoplasm of the central nervous system |
HP:0410030 | Cleft lip |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
diamond-blackfan anemia | MONDO:0015253 | D61 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIMPS:105650 | Orphanet:124 |
familial colorectal cancer type x | MONDO:0018604 | C18 | chapter2, Neoplasms | Orphanet:440437 |