MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2B05	2.55	Crystal Structure of 14-3-3 gamma in complex with a phosphoserine peptide
3UZD	1.86	Crystal structure of 14-3-3 GAMMA
4E2E	2.25	Crystal structure of a tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (YWHAG) from Homo sapiens at 2.25 A resolution
4J6S	3.08	14-3-3gamma complexed with the N-terminal sequence of tyrosine hydroxylase (residues 1-43)
4O46	2.9	14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228
5D3E	2.75	Crystal structure of human 14-3-3 gamma in complex with CFTR R-domain peptide pS768-pS795
6A5S	2.099	Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif
6BYJ	2.9	Structure of human 14-3-3 gamma bound to O-GlcNAc peptide
6BYL	3.35	Structure of 14-3-3 gamma bound to O-GlcNAcylated thr peptide
6BZD	2.67	Structure of 14-3-3 gamma R57E mutant bound to GlcNAcylated peptide
6FEL	2.84	Structure of 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser511
6GKF	2.598	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser139
6GKG	2.847	Structure of 14-3-3 gamma in complex with caspase-2 14-3-3 binding motif Ser164
6S9K	1.6	Structure of 14-3-3 gamma in complex with caspase-2 peptide containing 14-3-3 binding motif Ser139 and NLS
6SAD	2.753	Structure of 14-3-3 gamma in complex with double phosphorylated caspase-2 peptide on Ser139 and Ser164
6Y4K	3.0	Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and Fusicoccin A
6Y6B	3.08	Crystal structure of human 14-3-3 gamma in complex with CaMKK2 14-3-3 binding motif Ser100 and 16-OMe-Fusicoccin H
6ZBT	1.79949	Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser342
6ZC9	1.89896	Structure of 14-3-3 gamma in complex with Nedd4-2 14-3-3 binding motif Ser448
7A6R	2.7	Structure of 14-3-3 gamma in complex with DAPK2 peptide containing the 14-3-3 binding motif
7A6Y	2.5	Structure of 14-3-3 gamma in complex with DAPK2 peptide stabilized by FC-A

GO term

GO ontology	GO term	GO description
Biological Process	GO:0032869	cellular response to insulin stimulus
Biological Process	GO:0006469	negative regulation of protein kinase activity
Biological Process	GO:0006605	protein targeting
Biological Process	GO:0045664	regulation of neuron differentiation
Biological Process	GO:0009966	regulation of signal transduction
Biological Process	GO:0048167	regulation of synaptic plasticity
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0005159	insulin-like growth factor receptor binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0005080	protein kinase C binding
Molecular Function	GO:0008426	protein kinase C inhibitor activity
Molecular Function	GO:0030971	receptor tyrosine kinase binding
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005925	focal adhesion
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0098793	presynapse

InterPro / Pfam

InterPro	InterPro name
IPR000308	14-3-3 protein
IPR023409	14-3-3 protein, conserved site
IPR023410	14-3-3 domain
IPR036815	14-3-3 domain superfamily

Pfam	Pfam name
PF00244	14-3-3 protein

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-111447	Activation of BAD and translocation to mitochondria	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-380259	Loss of Nlp from mitotic centrosomes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-380270	Recruitment of mitotic centrosome proteins and complexes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-380284	Loss of proteins required for interphase microtubule organization from the centrosome	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-380320	Recruitment of NuMA to mitotic centrosomes	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-5620912	Anchoring of the basal body to the plasma membrane	Leaf	R-HSA-1852241	Organelle biogenesis and maintenance
R-HSA-5625740	RHO GTPases activate PKNs	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5628897	TP53 Regulates Metabolic Genes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-8854518	AURKA Activation by TPX2	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9614399	Regulation of localization of FOXO transcription factors	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	Leaf	R-HSA-1643685	Disease
R-HSA-9755779	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000250

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000252	Microcephaly
HP:0000348	High forehead
HP:0000494	Downslanted palpebral fissures
HP:0000504	Abnormality of vision
HP:0000508	Ptosis
HP:0000546	Retinal degeneration
HP:0000639	Nystagmus
HP:0000648	Optic atrophy
HP:0000668	Hypodontia
HP:0000708	Atypical behavior
HP:0000717	Autism
HP:0000739	Anxiety
HP:0000750	Delayed speech and language development
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001251	Ataxia
HP:0001252	Hypotonia
HP:0001257	Spasticity
HP:0001263	Global developmental delay
HP:0001265	Hyporeflexia
HP:0001268	Mental deterioration
HP:0001273	Abnormal corpus callosum morphology
HP:0001290	Generalized hypotonia
HP:0001298	Encephalopathy
HP:0001315	Reduced tendon reflexes
HP:0001336	Myoclonus
HP:0001337	Tremor
HP:0001388	Joint laxity
HP:0001508	Failure to thrive
HP:0001558	Decreased fetal movement
HP:0002020	Gastroesophageal reflux
HP:0002059	Cerebral atrophy
HP:0002063	Rigidity
HP:0002121	Generalized non-motor (absence) seizure
HP:0002133	Status epilepticus
HP:0002136	Broad-based gait
HP:0002317	Unsteady gait
HP:0002345	Action tremor
HP:0002353	EEG abnormality
HP:0002355	Difficulty walking
HP:0002370	Poor coordination
HP:0002376	Developmental regression
HP:0002392	EEG with polyspike wave complexes
HP:0002421	Poor head control
HP:0002509	Limb hypertonia
HP:0002521	Hypsarrhythmia
HP:0002650	Scoliosis
HP:0003593	Infantile onset
HP:0004305	Involuntary movements
HP:0004322	Short stature
HP:0007018	Attention deficit hyperactivity disorder
HP:0008770	Obsessive-compulsive trait
HP:0010844	EEG with multifocal slow activity
HP:0011153	Focal motor seizure
HP:0011443	Abnormality of coordination
HP:0011968	Feeding difficulties
HP:0012444	Brain atrophy
HP:0012447	Abnormal myelination
HP:0012547	Abnormal involuntary eye movements
HP:0032794	Myoclonic seizure
HP:0100660	Dyskinesia
HP:0100710	Impulsivity

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Approved
adrenal gland	glandular cells	Medium	Approved
appendix	glandular cells	Medium	Approved
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	Medium	Approved
breast	adipocytes	Medium	Approved
breast	glandular cells	Medium	Approved
breast	myoepithelial cells	Medium	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	glial cells	High	Approved
caudate	neuronal cells	High	Approved
cerebellum	Purkinje cells	High	Approved
cerebellum	cells in granular layer	High	Approved
cerebellum	cells in molecular layer	High	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	glial cells	Medium	Approved
cerebral cortex	neuronal cells	High	Approved
cerebral cortex	neuropil	Low	Approved
cervix	glandular cells	Medium	Approved
cervix	squamous epithelial cells	Medium	Approved
colon	endothelial cells	Medium	Approved
colon	glandular cells	Medium	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	cells in endometrial stroma	High	Approved
endometrium 1	glandular cells	High	Approved
endometrium 2	cells in endometrial stroma	Low	Approved
endometrium 2	glandular cells	High	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Medium	Approved
fallopian tube	glandular cells	Medium	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Medium	Approved
hippocampus	glial cells	Medium	Approved
hippocampus	neuronal cells	High	Approved
kidney	cells in glomeruli	Medium	Approved
kidney	cells in tubules	Medium	Approved
liver	cholangiocytes	Medium	Approved
liver	hepatocytes	Medium	Approved
lung	alveolar cells	Medium	Approved
lung	macrophages	High	Approved
lymph node	germinal center cells	Medium	Approved
lymph node	non-germinal center cells	Medium	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
oral mucosa	squamous epithelial cells	Medium	Approved
ovary	follicle cells	Medium	Approved
ovary	ovarian stroma cells	Medium	Approved
pancreas	exocrine glandular cells	Medium	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	decidual cells	High	Approved
placenta	trophoblastic cells	High	Approved
prostate	glandular cells	High	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Low	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	Medium	Approved
skin 1	fibroblasts	Medium	Approved
skin 1	keratinocytes	Medium	Approved
skin 1	melanocytes	Medium	Approved
skin 2	epidermal cells	Medium	Approved
small intestine	glandular cells	Medium	Approved
smooth muscle	smooth muscle cells	Low	Approved
soft tissue 1	chondrocytes	Low	Approved
soft tissue 1	fibroblasts	Medium	Approved
soft tissue 1	peripheral nerve	Medium	Approved
soft tissue 2	chondrocytes	Low	Approved
soft tissue 2	fibroblasts	Medium	Approved
soft tissue 2	peripheral nerve	Medium	Approved
spleen	cells in red pulp	Medium	Approved
spleen	cells in white pulp	Medium	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	High	Approved
testis	cells in seminiferous ducts	High	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	Medium	Approved
tonsil	non-germinal center cells	Medium	Approved
tonsil	squamous epithelial cells	Medium	Approved
urinary bladder	urothelial cells	High	Approved
vagina	squamous epithelial cells	Low	Approved

Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
undetermined early-onset epileptic encephalopathy	MONDO:0018614	G40	chapter6, Diseases of the nervous system		Orphanet:442835
developmental and epileptic encephalopathy, 56	MONDO:0033365	G40	chapter6, Diseases of the nervous system	OMIM:617665

Summary of P61981

Gene: YWHAG
Protein: 14-3-3 protein gamma

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P61981

Gene: YWHAG Protein: 14-3-3 protein gamma

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: YWHAG
Protein: 14-3-3 protein gamma