Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2BR9 | 1.75 | 14-3-3 Protein Epsilon (Human) Complexed to Peptide |
| 3UAL | 1.8 | Crystal Structure of 14-3-3 epsilon with Mlf1 peptide |
| 3UBW | 1.9 | Complex of 14-3-3 isoform epsilon, a Mlf1 phosphopeptide and a small fragment hit from a FBDD screen |
| 6EIH | 2.7 | The crystal structure of 14-3-3 epsilon in complex with the phosphorylated NELFE peptide |
| 7C8E | 3.16 | Crystal Structure of 14-3-3 epsilon with 9J10 peptide |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:0034605 | cellular response to heat |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0021766 | hippocampus development |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0086013 | membrane repolarization during cardiac muscle cell action potential |
| Biological Process | GO:1905913 | negative regulation of calcium ion export across plasma membrane |
| Biological Process | GO:1901020 | negative regulation of calcium ion transmembrane transporter activity |
| Biological Process | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0046827 | positive regulation of protein export from nucleus |
| Biological Process | GO:0034504 | protein localization to nucleus |
| Biological Process | GO:0006605 | protein targeting |
| Biological Process | GO:0051480 | regulation of cytosolic calcium ion concentration |
| Biological Process | GO:0086091 | regulation of heart rate by cardiac conduction |
| Biological Process | GO:0003064 | regulation of heart rate by hormone |
| Biological Process | GO:0060306 | regulation of membrane repolarization |
| Biological Process | GO:0007346 | regulation of mitotic cell cycle |
| Biological Process | GO:1901016 | regulation of potassium ion transmembrane transporter activity |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0021762 | substantia nigra development |
| Molecular Function | GO:0023026 | MHC class II protein complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0045296 | cadherin binding |
| Molecular Function | GO:0005246 | calcium channel regulator activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042826 | histone deacetylase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0050815 | phosphoserine residue binding |
| Molecular Function | GO:0015459 | potassium channel regulator activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0019903 | protein phosphatase binding |
| Molecular Function | GO:0097110 | scaffold protein binding |
| Molecular Function | GO:0044325 | transmembrane transporter binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-111447 | Activation of BAD and translocation to mitochondria | Leaf | R-HSA-5357801 | Programmed Cell Death |
| R-HSA-1445148 | Translocation of SLC2A4 (GLUT4) to the plasma membrane | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-2028269 | Signaling by Hippo | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-205025 | NADE modulates death signalling | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-3371511 | HSF1 activation | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-380259 | Loss of Nlp from mitotic centrosomes | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome | Internal node | R-HSA-1640170 | Cell Cycle |
| R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-5620912 | Anchoring of the basal body to the plasma membrane | Leaf | R-HSA-1852241 | Organelle biogenesis and maintenance |
| R-HSA-5625740 | RHO GTPases activate PKNs | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-5628897 | TP53 Regulates Metabolic Genes | Leaf | R-HSA-74160 | Gene expression (Transcription) |
| R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-8854518 | AURKA Activation by TPX2 | Leaf | R-HSA-1640170 | Cell Cycle |
| R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models | Leaf | R-HSA-1643685 | Disease |
| R-HSA-8876198 | RAB GEFs exchange GTP for GDP on RABs | Leaf | R-HSA-5653656 | Vesicle-mediated transport |
| R-HSA-9735871 | SARS-CoV-1 targets host intracellular signalling and regulatory pathways | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9755779 | SARS-CoV-2 targets host intracellular signalling and regulatory pathways | Leaf | R-HSA-1643685 | Disease |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:12917326 |
| Melanosome | ECO:0000269 | PubMed:12042314 |
| Melanosome | ECO:0000269 | PubMed:17081065 |
| Nucleus | ECO:0000269 | PubMed:12917326 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000023 | Inguinal hernia |
| HP:0000098 | Tall stature |
| HP:0000112 | Nephropathy |
| HP:0000160 | Narrow mouth |
| HP:0000177 | Abnormal upper lip morphology |
| HP:0000218 | High palate |
| HP:0000286 | Epicanthus |
| HP:0000316 | Hypertelorism |
| HP:0000348 | High forehead |
| HP:0000369 | Low-set ears |
| HP:0000445 | Wide nose |
| HP:0000463 | Anteverted nares |
| HP:0000470 | Short neck |
| HP:0000494 | Downslanted palpebral fissures |
| HP:0000960 | Sacral dimple |
| HP:0001250 | Seizure |
| HP:0001251 | Ataxia |
| HP:0001252 | Hypotonia |
| HP:0001263 | Global developmental delay |
| HP:0001339 | Lissencephaly |
| HP:0001374 | Congenital hip dislocation |
| HP:0001510 | Growth delay |
| HP:0001539 | Omphalocele |
| HP:0001561 | Polyhydramnios |
| HP:0001626 | Abnormality of the cardiovascular system |
| HP:0002007 | Frontal bossing |
| HP:0002079 | Hypoplasia of the corpus callosum |
| HP:0002119 | Ventriculomegaly |
| HP:0002120 | Cerebral cortical atrophy |
| HP:0002353 | EEG abnormality |
| HP:0003196 | Short nose |
| HP:0004209 | Clinodactyly of the 5th finger |
| HP:0008736 | Hypoplasia of penis |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| appendix | lymphoid tissue | High | Approved |
| bone marrow | hematopoietic cells | High | Approved |
| breast | adipocytes | Medium | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Medium | Approved |
| caudate | glial cells | Medium | Approved |
| caudate | neuronal cells | High | Approved |
| cerebellum | Purkinje cells | Medium | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebellum | cells in molecular layer | High | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | glial cells | Medium | Approved |
| cerebral cortex | neuronal cells | High | Approved |
| cerebral cortex | neuropil | Medium | Approved |
| cervix | glandular cells | Medium | Approved |
| cervix | squamous epithelial cells | Low | Approved |
| colon | endothelial cells | Medium | Approved |
| colon | glandular cells | Medium | Approved |
| colon | peripheral nerve/ganglion | Medium | Approved |
| duodenum | glandular cells | Medium | Approved |
| endometrium 1 | cells in endometrial stroma | Medium | Approved |
| endometrium 1 | glandular cells | High | Approved |
| endometrium 2 | cells in endometrial stroma | Low | Approved |
| endometrium 2 | glandular cells | High | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | High | Approved |
| gallbladder | glandular cells | Medium | Approved |
| hippocampus | glial cells | Medium | Approved |
| hippocampus | neuronal cells | High | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | Medium | Approved |
| liver | cholangiocytes | High | Approved |
| lung | alveolar cells | Medium | Approved |
| lung | macrophages | Low | Approved |
| lymph node | germinal center cells | High | Approved |
| lymph node | non-germinal center cells | High | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | follicle cells | Low | Approved |
| ovary | ovarian stroma cells | Medium | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Medium | Approved |
| parathyroid gland | glandular cells | High | Approved |
| placenta | decidual cells | High | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Medium | Approved |
| rectum | glandular cells | High | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | High | Approved |
| skin 1 | keratinocytes | Medium | Approved |
| skin 1 | melanocytes | Medium | Approved |
| small intestine | glandular cells | Medium | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | chondrocytes | Low | Approved |
| soft tissue 1 | fibroblasts | Low | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Low | Approved |
| spleen | cells in red pulp | Medium | Approved |
| spleen | cells in white pulp | High | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | High | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | cells in seminiferous ducts | High | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | non-germinal center cells | High | Approved |
| tonsil | squamous epithelial cells | High | Approved |
| urinary bladder | urothelial cells | High | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|