Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3TU5 | 3.0 | Actin complex with Gelsolin Segment 1 fused to Cobl segment |
| 4PL7 | 2.3 | Structure of Komagataella pastoris actin-thymosin beta4 hybrid |
| 4PL8 | 2.0 | Structure of rabbit skeletal muscle actin in complex with a hybrid peptide comprising thymosin beta4 and the lysine-rich region of Cordon-Bleu |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0007253 | cytoplasmic sequestering of NF-kappaB |
| Biological Process | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| Biological Process | GO:1901223 | negative regulation of NIK/NF-kappaB signaling |
| Biological Process | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding |
| Biological Process | GO:1902807 | negative regulation of cell cycle G1/S phase transition |
| Biological Process | GO:1902037 | negative regulation of hematopoietic stem cell differentiation |
| Biological Process | GO:0032717 | negative regulation of interleukin-8 production |
| Biological Process | GO:2001171 | positive regulation of ATP biosynthetic process |
| Biological Process | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| Biological Process | GO:2001028 | positive regulation of endothelial cell chemotaxis |
| Biological Process | GO:1905273 | positive regulation of proton-transporting ATP synthase activity, rotational mechanism |
| Biological Process | GO:1901222 | regulation of NIK/NF-kappaB signaling |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:0050727 | regulation of inflammatory response |
| Biological Process | GO:0042989 | sequestering of actin monomers |
| Biological Process | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003785 | actin monomer binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031093 | platelet alpha granule lumen |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-114608 | Platelet degranulation | Leaf | R-HSA-109582 | Hemostasis |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, cytoskeleton | ECO:0000269 | PubMed:1999398 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | Low | Enhanced |
| appendix | glandular cells | Low | Enhanced |
| appendix | lymphoid tissue | Medium | Enhanced |
| bone marrow | hematopoietic cells | High | Enhanced |
| caudate | glial cells | Low | Enhanced |
| caudate | neuronal cells | Medium | Enhanced |
| cerebral cortex | glial cells | Low | Enhanced |
| cerebral cortex | neuronal cells | Medium | Enhanced |
| cerebral cortex | neuropil | Medium | Enhanced |
| colon | endothelial cells | Medium | Enhanced |
| colon | glandular cells | Medium | Enhanced |
| endometrium 2 | cells in endometrial stroma | Low | Enhanced |
| epididymis | glandular cells | Low | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| kidney | cells in glomeruli | Low | Enhanced |
| kidney | cells in tubules | Low | Enhanced |
| lung | macrophages | Medium | Enhanced |
| lymph node | germinal center cells | Low | Enhanced |
| lymph node | non-germinal center cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Low | Enhanced |
| rectum | glandular cells | Low | Enhanced |
| seminal vesicle | glandular cells | Medium | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 1 | Langerhans | Medium | Enhanced |
| skin 1 | fibroblasts | Medium | Enhanced |
| skin 1 | keratinocytes | Low | Enhanced |
| skin 2 | epidermal cells | Low | Enhanced |
| soft tissue 1 | fibroblasts | Medium | Enhanced |
| soft tissue 2 | fibroblasts | Medium | Enhanced |
| spleen | cells in red pulp | Low | Enhanced |
| stomach 2 | glandular cells | Low | Enhanced |
| testis | Leydig cells | Low | Enhanced |
| testis | spermatogonia cells | Medium | Enhanced |
| tonsil | germinal center cells | Medium | Enhanced |
| tonsil | non-germinal center cells | Medium | Enhanced |
| urinary bladder | urothelial cells | Medium | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|