Structure
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 4UG0 | 3.6 | STRUCTURE OF THE HUMAN 80S RIBOSOME |
| 4V6X | 5.0 | Structure of the human 80S ribosome |
| 5AJ0 | 3.5 | Cryo electron microscopy of actively translating human polysomes (POST state). |
| 5LKS | 3.6 | Structure-function insights reveal the human ribosome as a cancer target for antibiotics |
| 5T2C | 3.6 | CryoEM structure of the human ribosome at 3.6 Angstrom resolution |
| 6IP5 | 3.9 | Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii) |
| 6IP6 | 4.5 | Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii) |
| 6IP8 | 3.9 | Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv) |
| 6LQM | 3.09 | Cryo-EM structure of a pre-60S ribosomal subunit - state C |
| 6LSR | 3.13 | Cryo-EM structure of a pre-60S ribosomal subunit - state B |
Showing 1 to 10 of 35 entries
GO term
GO ontology
| GO term | GO description |
|---|---|---|
| Biological Process | GO:0070314 | G1 to G0 transition |
| Biological Process | GO:0072717 | cellular response to actinomycin D |
| Biological Process | GO:0002181 | cytoplasmic translation |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:1904667 | negative regulation of ubiquitin protein ligase activity |
| Biological Process | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0010628 | positive regulation of gene expression |
| Biological Process | GO:1901798 | positive regulation of signal transduction by p53 class mediator |
| Biological Process | GO:0050821 | protein stabilization |
Showing 1 to 10 of 32 entries
Reactome
| Reactome
| Reactome Name | Node type
| Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-156902 | Peptide chain elongation | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-192823 | Viral mRNA Translation | Leaf | R-HSA-1643685 | Disease |
| R-HSA-2408557 | Selenocysteine synthesis | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-72689 | Formation of a pool of free 40S subunits | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-72764 | Eukaryotic Translation Termination | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | Leaf | R-HSA-1266738 | Developmental Biology |
Showing 1 to 10 of 13 entries
Subcellular location
| Location
| ECO term
| Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:23636399 |
Showing 1 to 1 of 1 entries
Interactor | Variant | Drug
Tissue and cell type
| Tissue
| Cell type
| Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | Medium | Approved |
| appendix | glandular cells | High | Approved |
| appendix | lymphoid tissue | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | adipocytes | Low | Approved |
| breast | glandular cells | High | Approved |
| breast | myoepithelial cells | High | Approved |
| bronchus | respiratory epithelial cells | High | Approved |
| caudate | neuronal cells | High | Approved |
Showing 1 to 10 of 74 entries