Structure
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1UR6 | NMR based structural model of the UbcH5B-CNOT4 complex | |
| 1W4U | NMR solution structure of the ubiquitin conjugating enzyme UbcH5B | |
| 2CLW | 1.945 | Crystal structure of human ubiquitin-conjugating enzyme UbcH5B |
| 2ESK | 1.36 | Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b, wild-type |
| 2ESO | 1.5 | Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ile37Ala |
| 2ESP | 1.52 | Human ubiquitin-conjugating enzyme (E2) UbcH5b mutant Ile88Ala |
| 2ESQ | 1.44 | Human Ubiquitin-Conjugating Enzyme (E2) UbcH5b mutant Ser94Gly |
| 3A33 | 2.2 | UbcH5b~Ubiquitin Conjugate |
| 3JVZ | 3.3 | E2~Ubiquitin-HECT |
| 3JW0 | 3.1 | E2~Ubiquitin-HECT |
Showing 1 to 10 of 47 entries
GO term
GO ontology
| GO term | GO description |
|---|---|---|
| Biological Process | GO:0070936 | protein K48-linked ubiquitination |
| Biological Process | GO:0051865 | protein autoubiquitination |
| Biological Process | GO:0036211 | protein modification process |
| Biological Process | GO:0000209 | protein polyubiquitination |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
Showing 1 to 10 of 17 entries
InterPro / Pfam
Reactome
| Reactome
| Reactome Name | Node type
| Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1234176 | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment | Leaf | R-HSA-168256 | Immune System |
| R-HSA-202424 | Downstream TCR signaling | Leaf | R-HSA-168256 | Immune System |
| R-HSA-2871837 | FCERI mediated NF-kB activation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-5357905 | Regulation of TNFR1 signaling | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | Internal node | R-HSA-168256 | Immune System |
| R-HSA-8866652 | Synthesis of active ubiquitin: roles of E1 and E2 enzymes | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-8866654 | E3 ubiquitin ligases ubiquitinate target proteins | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-8951664 | Neddylation | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-9033241 | Peroxisomal protein import | Internal node | R-HSA-9609507 | Protein localization |
Showing 1 to 10 of 14 entries
Interactor | Variant | Drug
Tissue and cell type
| Tissue
| Cell type
| Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| bone marrow | hematopoietic cells | Medium | Approved |
| breast | adipocytes | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Low | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebral cortex | neuronal cells | Low | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Low | Approved |
Showing 1 to 10 of 50 entries