MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.3.2.27	Transferases; Acyltransferases; Aminoacyltransferases; RING-type E3 ubiquitin transferase
2.3.2.32	Transferases; Acyltransferases; Aminoacyltransferases; cullin-RING-type E3 NEDD8 transferase

Structure

PDB	Resolution (Å)	PDB name
1LDJ	3.0	Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
1LDK	3.1	Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF Ubiquitin Ligase Complex
1U6G	3.1	Crystal Structure of The Cand1-Cul1-Roc1 Complex
2HYE	3.1	Crystal Structure of the DDB1-Cul4A-Rbx1-SV5V Complex
2LGV		Rbx1
3DPL	2.6	Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation.
3DQV	3.0	Structural Insights into NEDD8 Activation of Cullin-RING Ligases: Conformational Control of Conjugation
3RTR	3.21	A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases
4F52	3.0	Structure of a Glomulin-RBX1-CUL1 complex
4P5O	3.1071	Structure of an RBX1-UBC12~NEDD8-CUL1-DCN1 complex: a RING-E3-E2~ubiquitin-like protein-substrate intermediate trapped in action
5N4W	3.9	Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex
6R6H	8.4	Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
6R7F	8.2	Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
6R7H	8.8	Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
6R7I	5.9	Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
6R7N	6.5	Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
6TTU	3.7	Ubiquitin Ligation to substrate by a cullin-RING E3 ligase at 3.7A resolution: NEDD8-CUL1-RBX1 N98R-SKP1-monomeric b-TRCP1dD-IkBa-UB~UBE2D2
7B5L	3.8	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-Cyclin A-CDK2-p27-UBE2L3~Ub~ARIH1. Transition State 1
7B5M	3.91	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-SKP1-SKP2-CKSHS1-p27~Ub~ARIH1. Transition State 2
7B5N	3.6	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: NEDD8-CUL1-RBX1-UBE2L3~Ub~ARIH1.
7B5S	3.6	Ubiquitin ligation to F-box protein substrates by SCF-RBR E3-E3 super-assembly: CUL1-RBX1-ARIH1 Ariadne. Transition State 1
7OKQ	8.4	Cryo-EM Structure of the DDB1-DCAF1-CUL4A-RBX1 Complex
7PLO	2.8	H. sapiens replisome-CUL2/LRR1 complex
7Z8B	2.8	Structure of CRL7FBXW8 reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0006281	DNA repair
Biological Process	GO:0000165	MAPK cascade
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:0034644	cellular response to UV
Biological Process	GO:0062197	cellular response to chemical stress
Biological Process	GO:0090090	negative regulation of canonical Wnt signaling pathway
Biological Process	GO:0032480	negative regulation of type I interferon production
Biological Process	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:1902499	positive regulation of protein autoubiquitination
Biological Process	GO:0045732	positive regulation of protein catabolic process
Biological Process	GO:0043687	post-translational protein modification
Biological Process	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
Biological Process	GO:0070936	protein K48-linked ubiquitination
Biological Process	GO:0006513	protein monoubiquitination
Biological Process	GO:0045116	protein neddylation
Biological Process	GO:0000209	protein polyubiquitination
Biological Process	GO:0016567	protein ubiquitination
Biological Process	GO:0006511	ubiquitin-dependent protein catabolic process
Molecular Function	GO:0061663	NEDD8 ligase activity
Molecular Function	GO:0019788	NEDD8 transferase activity
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function	GO:0097602	cullin family protein binding
Molecular Function	GO:0060090	molecular adaptor activity
Molecular Function	GO:0061630	ubiquitin protein ligase activity
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Molecular Function	GO:0034450	ubiquitin-ubiquitin ligase activity
Molecular Function	GO:0008270	zinc ion binding
Cellular Component	GO:0031462	Cul2-RING ubiquitin ligase complex
Cellular Component	GO:0031463	Cul3-RING ubiquitin ligase complex
Cellular Component	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex
Cellular Component	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex
Cellular Component	GO:0031466	Cul5-RING ubiquitin ligase complex
Cellular Component	GO:0031467	Cul7-RING ubiquitin ligase complex
Cellular Component	GO:0019005	SCF ubiquitin ligase complex
Cellular Component	GO:0031461	cullin-RING ubiquitin ligase complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus

InterPro / Pfam

InterPro	InterPro name
IPR001841	Zinc finger, RING-type
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR024766	Zinc finger, RING-H2-type

Pfam	Pfam name
PF12678	RING-H2 zinc finger domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	Leaf	R-HSA-73894	DNA Repair
R-HSA-1170546	Prolactin receptor signaling	Leaf	R-HSA-168256	Immune System
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-180585	Vif-mediated degradation of APOBEC3G	Leaf	R-HSA-1643685	Disease
R-HSA-195253	Degradation of beta-catenin by the destruction complex	Internal node	R-HSA-162582	Signal Transduction
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-2644607	Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	Leaf	R-HSA-1643685	Disease
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-4641258	Degradation of DVL	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5610780	Degradation of GLI1 by the proteasome	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5610783	Degradation of GLI2 by the proteasome	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5632684	Hedgehog 'on' state	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5658442	Regulation of RAS by GAPs	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5696394	DNA Damage Recognition in GG-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-5696395	Formation of Incision Complex in GG-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-5696400	Dual Incision in GG-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	Leaf	R-HSA-73894	DNA Repair
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	Internal node	R-HSA-73894	DNA Repair
R-HSA-6782135	Dual incision in TC-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-68949	Orc1 removal from chromatin	Leaf	R-HSA-69306	DNA Replication
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-8939902	Regulation of RUNX2 expression and activity	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8951664	Neddylation	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-9020702	Interleukin-1 signaling	Internal node	R-HSA-168256	Immune System
R-HSA-9604323	Negative regulation of NOTCH4 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9679191	Potential therapeutics for SARS	Leaf	R-HSA-1643685	Disease
R-HSA-9708530	Regulation of BACH1 activity	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-9725371	Nuclear events stimulated by ALK signaling in cancer	Leaf	R-HSA-1643685	Disease
R-HSA-9755511	KEAP1-NFE2L2 pathway	Internal node	R-HSA-8953897	Cellular responses to stimuli
R-HSA-9762114	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	Leaf	R-HSA-168256	Immune System

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:11027288
Nucleus	ECO:0000269	PubMed:11027288

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P62877

Gene: RBX1, RNF75, ROC1
Protein: E3 ubiquitin-protein ligase RBX1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P62877

Gene: RBX1, RNF75, ROC1 Protein: E3 ubiquitin-protein ligase RBX1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: RBX1, RNF75, ROC1
Protein: E3 ubiquitin-protein ligase RBX1