MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2KHW		Solution Structure of the human Polymerase iota UBM2-Ubiquitin Complex
2KOX		NMR residual dipolar couplings identify long range correlated motions in the backbone of the protein ubiquitin
2KTF		Solution NMR structure of human polymerase iota UBM2 in complex with ubiquitin
2KWU		Solution Structure of UBM2 of murine Polymerase iota in Complex with Ubiquitin
2KWV		Solution Structure of UBM1 of murine Polymerase iota in Complex with Ubiquitin
2L0F		Solution NMR structure of human polymerase iota UBM2 (P692A mutant) in complex with ubiquitin
2L0T		Solution structure of the complex of ubiquitin and the VHS domain of Stam2
2XK5	3.0	Crystal structure of K6-linked diubiquitin
3AXC	2.19	Crystal structure of linear diubiquitin
3I3T	2.59	Crystal structure of covalent ubiquitin-USP21 complex
3K9P	2.8	The crystal structure of E2-25K and ubiquitin complex
3N30	3.0	Crystal Structure of cubic Zn3-hUb (human ubiquitin) adduct
3N32	1.795	The crystal structure of human Ubiquitin adduct with Zeise's salt
3NHE	1.26	High Resolution Structure (1.26A) of USP2a in Complex with Ubiquitin
3NOB	2.19	Structure of K11-linked di-ubiquitin
3NS8	1.707	Crystal structure of an open conformation of Lys48-linked diubiquitin at pH 7.5
3PHD	3.0	Crystal structure of human HDAC6 in complex with ubiquitin
3PHW	2.0	OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with Ubiquitin
3TBL	2.903	Structure of Mono-ubiquitinated PCNA: Implications for DNA Polymerase Switching and Okazaki Fragment Maturation
3VDZ	2.4	Tailoring Encodable Lanthanide-Binding Tags as MRI Contrast Agents: xq-dSE3-Ubiquitin at 2.4 Angstroms
4R62	2.28	Structure of Rad6~Ub
4UG0	3.6	STRUCTURE OF THE HUMAN 80S RIBOSOME
4V6X	5.0	Structure of the human 80S ribosome
5A2Q	3.9	Structure of the HCV IRES bound to the human ribosome
5AJ0	3.5	Cryo electron microscopy of actively translating human polysomes (POST state).
5FLX	3.9	Mammalian 40S HCV-IRES complex
5LKS	3.6	Structure-function insights reveal the human ribosome as a cancer target for antibiotics
5T2C	3.6	CryoEM structure of the human ribosome at 3.6 Angstrom resolution
5WVO	1.997	Crystal structure of DNMT1 RFTS domain in complex with K18/K23 mono-ubiquitylated histone H3
5YDK	2.505	Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, tetrameric form
6DC6	3.14	Crystal structure of human ubiquitin activating enzyme E1 (Uba1) in complex with ubiquitin
6FEC	6.3	Human cap-dependent 48S pre-initiation complex
6G18	3.6	Cryo-EM structure of a late human pre-40S ribosomal subunit - State C
6G51	4.1	Cryo-EM structure of a late human pre-40S ribosomal subunit - State D
6G53	4.5	Cryo-EM structure of a late human pre-40S ribosomal subunit - State E
6G5H	3.6	Cryo-EM structure of a late human pre-40S ribosomal subunit - Mature
6G5I	3.5	Cryo-EM structure of a late human pre-40S ribosomal subunit - State R
6IP5	3.9	Cryo-EM structure of the CMV-stalled human 80S ribosome (Structure ii)
6IP6	4.5	Cryo-EM structure of the CMV-stalled human 80S ribosome with HCV IRES (Structure iii)
6IP8	3.9	Cryo-EM structure of the HCV IRES dependently initiated CMV-stalled 80S ribosome (Structure iv)
6J99	4.1	Cryo-EM structure of human DOT1L in complex with an H2B-monoubiquitinated nucleosome
6KFP	2.92	Crystal structure of MavC ternary complex
6KG6	2.39	Crystal structure of MavC/UBE2N-Ub complex
6KIU	3.2	Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom)
6KIV	4.0	Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom)
6KIW	4.0	Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom)
6OLE	3.1	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AP and PE tRNAs
6OLF	3.9	Human ribosome nascent chain complex (CDH1-RNC) stalled by a drug-like molecule with AA and PE tRNAs
6OLG	3.4	Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)
6OLI	3.5	Structure of human ribosome nascent chain complex selectively stalled by a drug-like small molecule (USO1-RNC)
6OLZ	3.9	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA
6OM0	3.1	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with AP and PE tRNAs
6OM7	3.7	Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs
6QZP	2.9	High-resolution cryo-EM structure of the human 80S ribosome
6SQO	1.41	Crystal structure of human MDM2 RING domain homodimer bound to UbcH5B-Ub
6SQR	2.18	Crystal structure of Cat MDM2-S429E RING domain bound to UbcH5B-Ub
6SQS	1.83	Crystal structure of cat phospho-Ser429 MDM2 RING domain bound to UbcH5B-Ub
6XA1	2.8	Structure of a drug-like compound stalled human translation termination complex
6Y0G	3.2	Structure of human ribosome in classical-PRE state
6Y57	3.5	Structure of human ribosome in hybrid-PRE state
6YBS	3.1	Structure of a human 48S translational initiation complex - head
6Z6L	3.0	Cryo-EM structure of human CCDC124 bound to 80S ribosomes
6Z6M	3.1	Cryo-EM structure of human 80S ribosomes bound to EBP1, eEF2 and SERBP1
6Z6N	2.9	Cryo-EM structure of human EBP1-80S ribosomes (focus on EBP1)
6ZLW	2.6	SARS-CoV-2 Nsp1 bound to the human 40S ribosomal subunit
6ZM7	2.7	SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex
6ZME	3.0	SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-eERF1 ribosome complex
6ZMI	2.6	SARS-CoV-2 Nsp1 bound to the human LYAR-80S ribosome complex
6ZMO	3.1	SARS-CoV-2 Nsp1 bound to the human LYAR-80S-eEF1a ribosome complex
6ZMT	3.0	SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex
6ZMW	3.7	Structure of a human 48S translational initiation complex
6ZN5	3.2	SARS-CoV-2 Nsp1 bound to a pre-40S-like ribosome complex - state 2
6ZOJ	2.8	SARS-CoV-2-Nsp1-40S complex, composite map
6ZOL	2.8	SARS-CoV-2-Nsp1-40S complex, focused on head
6ZON	3.0	SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1
6ZP4	2.9	SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 2
6ZUO	3.1	Human RIO1(kd)-StHA late pre-40S particle, structural state A (pre 18S rRNA cleavage)
6ZV6	2.9	Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage)
6ZVH	2.9	EDF1-ribosome complex
6ZVJ	3.8	Structure of a human ABCE1-bound 43S pre-initiation complex - State II
6ZXD	3.2	Cryo-EM structure of a late human pre-40S ribosomal subunit - State F1
6ZXE	3.0	Cryo-EM structure of a late human pre-40S ribosomal subunit - State F2
6ZXF	3.7	Cryo-EM structure of a late human pre-40S ribosomal subunit - State G
6ZXG	2.6	Cryo-EM structure of a late human pre-40S ribosomal subunit - State H1
6ZXH	2.7	Cryo-EM structure of a late human pre-40S ribosomal subunit - State H2
7A09	3.5	Structure of a human ABCE1-bound 43S pre-initiation complex - State III
7BWD	4.32	Structure of Dot1L-H2BK34ub Nucleosome Complex
7JQB	2.7	SARS-CoV-2 Nsp1 and rabbit 40S ribosome complex
7JQC	3.3	SARS-CoV-2 Nsp1, CrPV IRES and rabbit 40S ribosome complex
7K5I	2.9	SARS-COV-2 nsp1 in complex with human 40S ribosome
7MQ9	3.87	Cryo-EM structure of the human SSU processome, state pre-A1*
7MQA	2.7	Cryo-EM structure of the human SSU processome, state post-A1
7OOJ	2.6	Structure of D-Thr53 Ubiquitin
7QP6	4.7	Structure of the human 48S initiation complex in open state (h48S AUG open)
7QP7	3.7	Structure of the human 48S initiation complex in closed state (h48S AUG closed)
7R4X	2.15	Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map
7TQL	3.2	CryoEM structure of the human 40S small ribosomal subunit in complex with translation initiation factors eIF1A and eIF5B.
7WTT	3.1	Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (with CK1)
7WTU	3.0	Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A1 (without CK1)
7WTV	3.5	Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A2
7WTW	3.2	Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A3
7WTX	3.1	Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B1
7WTZ	3.0	Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B2
7WU0	3.3	Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-B3

GO term

GO ontology	GO term	GO description
Biological Process	GO:0002181	cytoplasmic translation
Biological Process	GO:0019941	modification-dependent protein catabolic process
Biological Process	GO:0016567	protein ubiquitination
Biological Process	GO:0042274	ribosomal small subunit biogenesis
Biological Process	GO:0006412	translation
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0031386	protein tag
Molecular Function	GO:0003735	structural constituent of ribosome
Molecular Function	GO:0031625	ubiquitin protein ligase binding
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0022626	cytosolic ribosome
Cellular Component	GO:0022627	cytosolic small ribosomal subunit
Cellular Component	GO:0030666	endocytic vesicle membrane
Cellular Component	GO:0005789	endoplasmic reticulum membrane
Cellular Component	GO:0010008	endosome membrane
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005741	mitochondrial outer membrane
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0015935	small ribosomal subunit
Cellular Component	GO:0032040	small-subunit processome
Cellular Component	GO:0031982	vesicle

InterPro / Pfam

InterPro	InterPro name
IPR000626	Ubiquitin-like domain
IPR002906	Ribosomal protein S27a
IPR011332	Zinc-binding ribosomal protein
IPR019954	Ubiquitin conserved site
IPR019956	Ubiquitin domain
IPR029071	Ubiquitin-like domain superfamily
IPR038582	S27a-like superfamily

Pfam	Pfam name
PF00240	Ubiquitin family
PF01599	Ribosomal protein S27a

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-5357905	Regulation of TNFR1 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-180585	Vif-mediated degradation of APOBEC3G	Leaf	R-HSA-1643685	Disease
R-HSA-69541	Stabilization of p53	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-1236974	ER-Phagosome pathway	Leaf	R-HSA-168256	Immune System
R-HSA-174490	Membrane binding and targetting of GAG proteins	Leaf	R-HSA-1643685	Disease
R-HSA-9762114	GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-6783310	Fanconi Anemia Pathway	Internal node	R-HSA-73894	DNA Repair
R-HSA-8866654	E3 ubiquitin ligases ubiquitinate target proteins	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-2672351	Stimuli-sensing channels	Internal node	R-HSA-382551	Transport of small molecules
R-HSA-5689880	Ub-specific processing proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9735869	SARS-CoV-1 modulates host translation machinery	Leaf	R-HSA-1643685	Disease
R-HSA-9664873	Pexophagy	Leaf	R-HSA-9612973	Autophagy
R-HSA-5689896	Ovarian tumor domain proteases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-917937	Iron uptake and transport	Internal node	R-HSA-382551	Transport of small molecules
R-HSA-5678895	Defective CFTR causes cystic fibrosis	Leaf	R-HSA-1643685	Disease
R-HSA-69481	G2/M Checkpoints	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-69017	CDK-mediated phosphorylation and removal of Cdc6	Leaf	R-HSA-69306	DNA Replication
R-HSA-68949	Orc1 removal from chromatin	Leaf	R-HSA-69306	DNA Replication
R-HSA-4641257	Degradation of AXIN	Leaf	R-HSA-162582	Signal Transduction
R-HSA-156902	Peptide chain elongation	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5205685	PINK1-PRKN Mediated Mitophagy	Leaf	R-HSA-9612973	Autophagy
R-HSA-175474	Assembly Of The HIV Virion	Internal node	R-HSA-1643685	Disease
R-HSA-2173795	Downregulation of SMAD2/3:SMAD4 transcriptional activity	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-174048	APC/C:Cdc20 mediated degradation of Cyclin B	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-5676590	NIK-->noncanonical NF-kB signaling	Leaf	R-HSA-168256	Immune System
R-HSA-8941858	Regulation of RUNX3 expression and activity	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9694493	Maturation of protein E	Leaf	R-HSA-1643685	Disease
R-HSA-168638	NOD1/2 Signaling Pathway	Leaf	R-HSA-168256	Immune System
R-HSA-195253	Degradation of beta-catenin by the destruction complex	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5696397	Gap-filling DNA repair synthesis and ligation in GG-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-5675221	Negative regulation of MAPK pathway	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5610780	Degradation of GLI1 by the proteasome	Leaf	R-HSA-162582	Signal Transduction
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9758274	Regulation of NF-kappa B signaling	Leaf	R-HSA-168256	Immune System
R-HSA-2559580	Oxidative Stress Induced Senescence	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-9755511	KEAP1-NFE2L2 pathway	Internal node	R-HSA-8953897	Cellular responses to stimuli
R-HSA-9013507	NOTCH3 Activation and Transmission of Signal to the Nucleus	Internal node	R-HSA-162582	Signal Transduction
R-HSA-72689	Formation of a pool of free 40S subunits	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-2559582	Senescence-Associated Secretory Phenotype (SASP)	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	Internal node	R-HSA-392499	Metabolism of proteins
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-1169408	ISG15 antiviral mechanism	Leaf	R-HSA-168256	Immune System
R-HSA-9604323	Negative regulation of NOTCH4 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5607761	Dectin-1 mediated noncanonical NF-kB signaling	Leaf	R-HSA-168256	Immune System
R-HSA-192823	Viral mRNA Translation	Leaf	R-HSA-1643685	Disease
R-HSA-1234176	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-9680350	Signaling by CSF1 (M-CSF) in myeloid cells	Leaf	R-HSA-168256	Immune System
R-HSA-162588	Budding and maturation of HIV virion	Leaf	R-HSA-1643685	Disease
R-HSA-975144	IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Leaf	R-HSA-168256	Immune System
R-HSA-72702	Ribosomal scanning and start codon recognition	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-382556	ABC-family proteins mediated transport	Internal node	R-HSA-382551	Transport of small molecules
R-HSA-8856825	Cargo recognition for clathrin-mediated endocytosis	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-110312	Translesion synthesis by REV1	Leaf	R-HSA-73894	DNA Repair
R-HSA-901032	ER Quality Control Compartment (ERQC)	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-4608870	Asymmetric localization of PCP proteins	Leaf	R-HSA-162582	Signal Transduction
R-HSA-202424	Downstream TCR signaling	Leaf	R-HSA-168256	Immune System
R-HSA-977225	Amyloid fiber formation	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9633012	Response of EIF2AK4 (GCN2) to amino acid deficiency	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-9705462	Inactivation of CSF3 (G-CSF) signaling	Leaf	R-HSA-168256	Immune System
R-HSA-8866652	Synthesis of active ubiquitin: roles of E1 and E2 enzymes	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-3134975	Regulation of innate immune responses to cytosolic DNA	Internal node	R-HSA-168256	Immune System
R-HSA-2894862	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-110314	Recognition of DNA damage by PCNA-containing replication complex	Leaf	R-HSA-73894	DNA Repair
R-HSA-5693565	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Leaf	R-HSA-73894	DNA Repair
R-HSA-936964	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	Leaf	R-HSA-168256	Immune System
R-HSA-5654727	Negative regulation of FGFR2 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-6791226	Major pathway of rRNA processing in the nucleolus and cytosol	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-187577	SCF(Skp2)-mediated degradation of p27/p21	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-1799339	SRP-dependent cotranslational protein targeting to membrane	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9636383	Prevention of phagosomal-lysosomal fusion	Leaf	R-HSA-1643685	Disease
R-HSA-69601	Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-6804760	Regulation of TP53 Activity through Methylation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-8856828	Clathrin-mediated endocytosis	Internal node	R-HSA-5653656	Vesicle-mediated transport
R-HSA-72695	Formation of the ternary complex, and subsequently, the 43S complex	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-936440	Negative regulators of DDX58/IFIH1 signaling	Leaf	R-HSA-168256	Immune System
R-HSA-349425	Autodegradation of the E3 ubiquitin ligase COP1	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-209560	NF-kB is activated and signals survival	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5358346	Hedgehog ligand biogenesis	Internal node	R-HSA-162582	Signal Transduction
R-HSA-400253	Circadian Clock	Root	R-HSA-400253	Circadian Clock
R-HSA-174154	APC/C:Cdc20 mediated degradation of Securin	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9020702	Interleukin-1 signaling	Internal node	R-HSA-168256	Immune System
R-HSA-8939236	RUNX1 regulates transcription of genes involved in differentiation of HSCs	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-69231	Cyclin D associated events in G1	Internal node	R-HSA-1640170	Cell Cycle
R-HSA-2122947	NOTCH1 Intracellular Domain Regulates Transcription	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5357956	TNFR1-induced NFkappaB signaling pathway	Leaf	R-HSA-162582	Signal Transduction
R-HSA-975163	IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Leaf	R-HSA-168256	Immune System
R-HSA-8876493	InlA-mediated entry of Listeria monocytogenes into host cells	Leaf	R-HSA-1643685	Disease
R-HSA-1169091	Activation of NF-kappaB in B cells	Leaf	R-HSA-168256	Immune System
R-HSA-937072	TRAF6-mediated induction of TAK1 complex within TLR4 complex	Leaf	R-HSA-168256	Immune System
R-HSA-937042	IRAK2 mediated activation of TAK1 complex	Leaf	R-HSA-168256	Immune System
R-HSA-3785653	Myoclonic epilepsy of Lafora	Leaf	R-HSA-1643685	Disease
R-HSA-5696400	Dual Incision in GG-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-5689901	Metalloprotease DUBs	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-917729	Endosomal Sorting Complex Required For Transport (ESCRT)	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-2408557	Selenocysteine synthesis	Leaf	R-HSA-1430728	Metabolism
R-HSA-9708530	Regulation of BACH1 activity	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-2173788	Downregulation of TGF-beta receptor signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9692916	SARS-CoV-1 activates/modulates innate immune responses	Leaf	R-HSA-1643685	Disease
R-HSA-9637628	Modulation by Mtb of host immune system	Leaf	R-HSA-1643685	Disease
R-HSA-5654733	Negative regulation of FGFR4 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-8875360	InlB-mediated entry of Listeria monocytogenes into host cell	Leaf	R-HSA-1643685	Disease
R-HSA-2979096	NOTCH2 Activation and Transmission of Signal to the Nucleus	Leaf	R-HSA-162582	Signal Transduction
R-HSA-9033241	Peroxisomal protein import	Internal node	R-HSA-9609507	Protein localization
R-HSA-5684264	MAP3K8 (TPL2)-dependent MAPK1/3 activation	Leaf	R-HSA-168256	Immune System
R-HSA-110320	Translesion Synthesis by POLH	Leaf	R-HSA-73894	DNA Repair
R-HSA-6782135	Dual incision in TC-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-9706377	FLT3 signaling by CBL mutants	Leaf	R-HSA-1643685	Disease
R-HSA-201681	TCF dependent signaling in response to WNT	Internal node	R-HSA-162582	Signal Transduction
R-HSA-8852276	The role of GTSE1 in G2/M progression after G2 checkpoint	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2565942	Regulation of PLK1 Activity at G2/M Transition	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-983168	Antigen processing: Ubiquitination & Proteasome degradation	Leaf	R-HSA-168256	Immune System
R-HSA-2467813	Separation of Sister Chromatids	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2173791	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	Leaf	R-HSA-162582	Signal Transduction
R-HSA-8948751	Regulation of PTEN stability and activity	Leaf	R-HSA-162582	Signal Transduction
R-HSA-2559585	Oncogene Induced Senescence	Leaf	R-HSA-8953897	Cellular responses to stimuli
R-HSA-9014325	TICAM1,TRAF6-dependent induction of TAK1 complex	Leaf	R-HSA-168256	Immune System
R-HSA-5689877	Josephin domain DUBs	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-450302	activated TAK1 mediates p38 MAPK activation	Leaf	R-HSA-168256	Immune System
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-8863795	Downregulation of ERBB2 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-8939902	Regulation of RUNX2 expression and activity	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-75815	Ubiquitin-dependent degradation of Cyclin D	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-2691232	Constitutive Signaling by NOTCH1 HD Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-174178	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-4641263	Regulation of FZD by ubiquitination	Leaf	R-HSA-162582	Signal Transduction
R-HSA-450321	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	Leaf	R-HSA-168256	Immune System
R-HSA-179409	APC-Cdc20 mediated degradation of Nek2A	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-8948747	Regulation of PTEN localization	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5655862	Translesion synthesis by POLK	Leaf	R-HSA-73894	DNA Repair
R-HSA-5654726	Negative regulation of FGFR1 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-174184	Cdc20:Phospho-APC/C mediated degradation of Cyclin A	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-1253288	Downregulation of ERBB4 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5654732	Negative regulation of FGFR3 signaling	Internal node	R-HSA-162582	Signal Transduction
R-HSA-2173796	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9705671	SARS-CoV-2 activates/modulates innate and adaptive immune responses	Leaf	R-HSA-1643685	Disease
R-HSA-8854050	FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-174113	SCF-beta-TrCP mediated degradation of Emi1	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-5696395	Formation of Incision Complex in GG-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-5656169	Termination of translesion DNA synthesis	Leaf	R-HSA-73894	DNA Repair
R-HSA-72649	Translation initiation complex formation	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5696394	DNA Damage Recognition in GG-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-937039	IRAK1 recruits IKK complex	Leaf	R-HSA-168256	Immune System
R-HSA-9013973	TICAM1-dependent activation of IRF3/IRF7	Leaf	R-HSA-168256	Immune System
R-HSA-9646399	Aggrephagy	Leaf	R-HSA-9612973	Autophagy
R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5668541	TNFR2 non-canonical NF-kB pathway	Internal node	R-HSA-168256	Immune System
R-HSA-5675482	Regulation of necroptotic cell death	Internal node	R-HSA-5357801	Programmed Cell Death
R-HSA-9706369	Negative regulation of FLT3	Leaf	R-HSA-168256	Immune System
R-HSA-9648002	RAS processing	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5610783	Degradation of GLI2 by the proteasome	Leaf	R-HSA-162582	Signal Transduction
R-HSA-6807004	Negative regulation of MET activity	Internal node	R-HSA-162582	Signal Transduction
R-HSA-3322077	Glycogen synthesis	Leaf	R-HSA-1430728	Metabolism
R-HSA-168927	TICAM1, RIP1-mediated IKK complex recruitment	Leaf	R-HSA-168256	Immune System
R-HSA-8951664	Neddylation	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5632684	Hedgehog 'on' state	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5607764	CLEC7A (Dectin-1) signaling	Internal node	R-HSA-168256	Immune System
R-HSA-1236382	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	Leaf	R-HSA-1643685	Disease
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	Leaf	R-HSA-73894	DNA Repair
R-HSA-182971	EGFR downregulation	Leaf	R-HSA-162582	Signal Transduction
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-68867	Assembly of the pre-replicative complex	Internal node	R-HSA-69306	DNA Replication
R-HSA-9613829	Chaperone Mediated Autophagy	Leaf	R-HSA-9612973	Autophagy
R-HSA-1295596	Spry regulation of FGF signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5687128	MAPK6/MAPK4 signaling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5685942	HDR through Homologous Recombination (HRR)	Internal node	R-HSA-73894	DNA Repair
R-HSA-5362768	Hh mutants are degraded by ERAD	Leaf	R-HSA-1643685	Disease
R-HSA-9754678	SARS-CoV-2 modulates host translation machinery	Leaf	R-HSA-1643685	Disease
R-HSA-9615710	Late endosomal microautophagy	Leaf	R-HSA-9612973	Autophagy
R-HSA-2644606	Constitutive Signaling by NOTCH1 PEST Domain Mutants	Leaf	R-HSA-1643685	Disease
R-HSA-205043	NRIF signals cell death from the nucleus	Leaf	R-HSA-162582	Signal Transduction
R-HSA-4641258	Degradation of DVL	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5656121	Translesion synthesis by POLI	Leaf	R-HSA-73894	DNA Repair
R-HSA-912631	Regulation of signaling by CBL	Leaf	R-HSA-168256	Immune System
R-HSA-445989	TAK1-dependent IKK and NF-kappa-B activation	Internal node	R-HSA-168256	Immune System
R-HSA-2871837	FCERI mediated NF-kB activation	Leaf	R-HSA-168256	Immune System
R-HSA-937041	IKK complex recruitment mediated by RIP1	Leaf	R-HSA-168256	Immune System
R-HSA-8866427	VLDLR internalisation and degradation	Leaf	R-HSA-382551	Transport of small molecules
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-5693607	Processing of DNA double-strand break ends	Leaf	R-HSA-73894	DNA Repair
R-HSA-3769402	Deactivation of the beta-catenin transactivating complex	Leaf	R-HSA-162582	Signal Transduction
R-HSA-180534	Vpu mediated degradation of CD4	Leaf	R-HSA-1643685	Disease
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	Leaf	R-HSA-73894	DNA Repair
R-HSA-72764	Eukaryotic Translation Termination	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-5658442	Regulation of RAS by GAPs	Leaf	R-HSA-162582	Signal Transduction
R-HSA-174084	Autodegradation of Cdh1 by Cdh1:APC/C	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	Internal node	R-HSA-73894	DNA Repair
R-HSA-975110	TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	Leaf	R-HSA-168256	Immune System
R-HSA-209543	p75NTR recruits signalling complexes	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5610785	GLI3 is processed to GLI3R by the proteasome	Leaf	R-HSA-162582	Signal Transduction
R-HSA-211733	Regulation of activated PAK-2p34 by proteasome mediated degradation	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-6804757	Regulation of TP53 Degradation	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9645460	Alpha-protein kinase 1 signaling pathway	Leaf	R-HSA-168256	Immune System
R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus	Leaf	R-HSA-162582	Signal Transduction
R-HSA-5689603	UCH proteinases	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-168928	DDX58/IFIH1-mediated induction of interferon-alpha/beta	Internal node	R-HSA-168256	Immune System
R-HSA-9683683	Maturation of protein E	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000250
Nucleus	ECO:0000250
Nucleus, nucleolus	ECO:0000269	PubMed:34516797

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Supported
adrenal gland	glandular cells	High	Supported
appendix	glandular cells	Medium	Supported
bone marrow	hematopoietic cells	Medium	Supported
breast	adipocytes	Medium	Supported
breast	glandular cells	High	Supported
breast	myoepithelial cells	Medium	Supported
bronchus	respiratory epithelial cells	High	Supported
caudate	glial cells	High	Supported
caudate	neuronal cells	Medium	Supported
cerebellum	Purkinje cells	Medium	Supported
cerebellum	cells in granular layer	High	Supported
cerebellum	cells in molecular layer	High	Supported
cerebral cortex	endothelial cells	Medium	Supported
cerebral cortex	glial cells	High	Supported
cerebral cortex	neuronal cells	Medium	Supported
cerebral cortex	neuropil	Low	Supported
cervix	glandular cells	High	Supported
cervix	squamous epithelial cells	High	Supported
colon	endothelial cells	Medium	Supported
colon	glandular cells	Medium	Supported
colon	peripheral nerve/ganglion	Medium	Supported
duodenum	glandular cells	Medium	Supported
endometrium 1	cells in endometrial stroma	Medium	Supported
endometrium 1	glandular cells	High	Supported
endometrium 2	cells in endometrial stroma	Medium	Supported
endometrium 2	glandular cells	Medium	Supported
epididymis	glandular cells	Medium	Supported
esophagus	squamous epithelial cells	High	Supported
fallopian tube	glandular cells	High	Supported
gallbladder	glandular cells	High	Supported
heart muscle	cardiomyocytes	Low	Supported
hippocampus	glial cells	Low	Supported
hippocampus	neuronal cells	Medium	Supported
kidney	cells in glomeruli	Medium	Supported
kidney	cells in tubules	Medium	Supported
liver	cholangiocytes	Medium	Supported
liver	hepatocytes	High	Supported
lung	alveolar cells	Medium	Supported
lung	macrophages	Medium	Supported
lymph node	germinal center cells	Medium	Supported
lymph node	non-germinal center cells	Medium	Supported
nasopharynx	respiratory epithelial cells	High	Supported
oral mucosa	squamous epithelial cells	High	Supported
ovary	ovarian stroma cells	Medium	Supported
pancreas	exocrine glandular cells	Medium	Supported
pancreas	pancreatic endocrine cells	Medium	Supported
parathyroid gland	glandular cells	High	Supported
placenta	decidual cells	Low	Supported
placenta	trophoblastic cells	Medium	Supported
prostate	glandular cells	High	Supported
rectum	glandular cells	Medium	Supported
salivary gland	glandular cells	High	Supported
seminal vesicle	glandular cells	Medium	Supported
skeletal muscle	myocytes	High	Supported
skin 1	arrector pili muscle cells	High	Supported
skin 1	cells in basal layer	Medium	Supported
skin 1	cells in granular layer	High	Supported
skin 1	cells in spinous layer	High	Supported
skin 1	endothelial cells	High	Supported
skin 1	fibrohistiocytic cells	Medium	Supported
skin 1	hair follicles	High	Supported
skin 1	langerhans cells	Medium	Supported
skin 1	lymphocytes	High	Supported
skin 1	melanocytes	Medium	Supported
skin 1	sebaceous glands	High	Supported
skin 2	cells in basal layer	Medium	Supported
skin 2	cells in corneal layer	Low	Supported
skin 2	cells in granular layer	High	Supported
skin 2	cells in spinous layer	High	Supported
skin 2	endothelial cells	High	Supported
skin 2	fibrohistiocytic cells	High	Supported
skin 2	langerhans cells	High	Supported
skin 2	lymphocytes	High	Supported
skin 2	melanocytes	High	Supported
small intestine	glandular cells	High	Supported
smooth muscle	smooth muscle cells	High	Supported
soft tissue 2	fibroblasts	Medium	Supported
soft tissue 2	peripheral nerve	High	Supported
spleen	cells in red pulp	High	Supported
spleen	cells in white pulp	Medium	Supported
stomach 1	glandular cells	Medium	Supported
stomach 2	glandular cells	High	Supported
testis	Leydig cells	Medium	Supported
testis	elongated or late spermatids	High	Supported
testis	pachytene spermatocytes	Low	Supported
testis	sertoli cells	High	Supported
thyroid gland	glandular cells	High	Supported
tonsil	germinal center cells	High	Supported
tonsil	non-germinal center cells	High	Supported
tonsil	squamous epithelial cells	Medium	Supported
urinary bladder	urothelial cells	High	Supported
vagina	squamous epithelial cells	High	Supported

Summary of P62979

Gene: RPS27A, UBA80, UBCEP1
Protein: Ubiquitin-ribosomal protein eS31 fusion protein

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of P62979

Gene: RPS27A, UBA80, UBCEP1 Protein: Ubiquitin-ribosomal protein eS31 fusion protein

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: RPS27A, UBA80, UBCEP1
Protein: Ubiquitin-ribosomal protein eS31 fusion protein