Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.6.5.-
Hydrolases;
Acting on acid anhydrides;
Acting on GTP to facilitate cellular and subcellular movement;
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0071364 | cellular response to epidermal growth factor stimulus |
| Biological Process | GO:0044829 | positive regulation by host of viral genome replication |
| Biological Process | GO:1900022 | regulation of D-erythro-sphingosine kinase activity |
| Biological Process | GO:1904714 | regulation of chaperone-mediated autophagy |
| Biological Process | GO:0006412 | translation |
| Biological Process | GO:0006414 | translational elongation |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0003924 | GTPase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0060090 | molecular adaptor activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0000049 | tRNA binding |
| Molecular Function | GO:0003746 | translation elongation factor activity |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098574 | cytoplasmic side of lysosomal membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0022626 | cytosolic ribosome |
| Cellular Component | GO:0005853 | eukaryotic translation elongation factor 1 complex |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1904813 | ficolin-1-rich granule lumen |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0032587 | ruffle membrane |
| Cellular Component | GO:0034774 | secretory granule lumen |
| InterPro
|
InterPro name |
|---|---|
| IPR000795 | Translational (tr)-type GTP-binding domain |
| IPR004160 | Translation elongation factor EFTu/EF1A, C-terminal |
| IPR004161 | Translation elongation factor EFTu-like, domain 2 |
| IPR004539 | Translation elongation factor EF1A, eukaryotic/archaeal |
| IPR009000 | Translation protein, beta-barrel domain superfamily |
| IPR009001 | Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR031157 | Tr-type G domain, conserved site |
| Pfam
|
Pfam name |
|---|---|
| PF00009 | Elongation factor Tu GTP binding domain |
| PF03143 | Elongation factor Tu C-terminal domain |
| PF03144 | Elongation factor Tu domain 2 |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-156842 | Eukaryotic Translation Elongation | Internal node | R-HSA-392499 | Metabolism of proteins |
| R-HSA-156902 | Peptide chain elongation | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-3371511 | HSF1 activation | Leaf | R-HSA-8953897 | Cellular responses to stimuli |
| R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-8876725 | Protein methylation | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-9613829 | Chaperone Mediated Autophagy | Leaf | R-HSA-9612973 | Autophagy |
| R-HSA-9735869 | SARS-CoV-1 modulates host translation machinery | Leaf | R-HSA-1643685 | Disease |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000269 | PubMed:26497934 |
| Cytoplasm | ECO:0000269 | PubMed:19158340 |
| Cytoplasm | ECO:0000269 | PubMed:8650580 |
| Nucleus | ECO:0000269 | PubMed:17177976 |
| Nucleus | ECO:0000269 | PubMed:8650580 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:8650580 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adrenal gland | glandular cells | High | Supported |
| appendix | glandular cells | Medium | Supported |
| bone marrow | hematopoietic cells | Medium | Supported |
| breast | glandular cells | High | Supported |
| breast | myoepithelial cells | Medium | Supported |
| bronchus | respiratory epithelial cells | High | Supported |
| caudate | glial cells | Medium | Supported |
| caudate | neuronal cells | Medium | Supported |
| cerebellum | Purkinje cells | High | Supported |
| cerebellum | cells in molecular layer | High | Supported |
| cerebral cortex | endothelial cells | Low | Supported |
| cerebral cortex | glial cells | Medium | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| cerebral cortex | neuropil | Low | Supported |
| cervix | glandular cells | High | Supported |
| cervix | squamous epithelial cells | High | Supported |
| colon | endothelial cells | Medium | Supported |
| colon | glandular cells | High | Supported |
| colon | peripheral nerve/ganglion | High | Supported |
| duodenum | glandular cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | Medium | Supported |
| endometrium 1 | glandular cells | High | Supported |
| endometrium 2 | cells in endometrial stroma | Medium | Supported |
| endometrium 2 | glandular cells | High | Supported |
| epididymis | glandular cells | High | Supported |
| esophagus | squamous epithelial cells | High | Supported |
| fallopian tube | glandular cells | High | Supported |
| gallbladder | glandular cells | High | Supported |
| hippocampus | glial cells | Low | Supported |
| hippocampus | neuronal cells | Medium | Supported |
| kidney | cells in glomeruli | Low | Supported |
| kidney | cells in tubules | Medium | Supported |
| liver | cholangiocytes | Low | Supported |
| liver | hepatocytes | Medium | Supported |
| lung | alveolar cells | Medium | Supported |
| lung | macrophages | Low | Supported |
| lymph node | germinal center cells | Medium | Supported |
| nasopharynx | respiratory epithelial cells | High | Supported |
| oral mucosa | squamous epithelial cells | High | Supported |
| ovary | follicle cells | Medium | Supported |
| ovary | ovarian stroma cells | Low | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| pancreas | pancreatic endocrine cells | Medium | Supported |
| parathyroid gland | glandular cells | Medium | Supported |
| placenta | trophoblastic cells | Medium | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | High | Supported |
| seminal vesicle | glandular cells | High | Supported |
| skeletal muscle | myocytes | High | Supported |
| skin 1 | Langerhans | Low | Supported |
| skin 1 | fibroblasts | High | Supported |
| skin 1 | keratinocytes | High | Supported |
| skin 1 | melanocytes | High | Supported |
| skin 2 | epidermal cells | High | Supported |
| small intestine | glandular cells | High | Supported |
| smooth muscle | smooth muscle cells | High | Supported |
| soft tissue 1 | chondrocytes | Medium | Supported |
| soft tissue 1 | fibroblasts | Medium | Supported |
| soft tissue 2 | fibroblasts | Medium | Supported |
| spleen | cells in red pulp | Medium | Supported |
| spleen | cells in white pulp | Low | Supported |
| stomach 1 | glandular cells | High | Supported |
| stomach 2 | glandular cells | High | Supported |
| testis | Leydig cells | Medium | Supported |
| testis | elongated or late spermatids | Medium | Supported |
| testis | spermatogonia cells | Medium | Supported |
| thyroid gland | glandular cells | High | Supported |
| tonsil | germinal center cells | Medium | Supported |
| tonsil | non-germinal center cells | Medium | Supported |
| tonsil | squamous epithelial cells | High | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | High | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|