Protein family
The protein has not catalytic activity
Protein sequence
Protein function
Publications
Catalytic activity
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 2E8P | Solution structure of the N-terminal SAM-domain of E74-like factor 3 |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0001824 | blastocyst development |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0030198 | extracellular matrix organization |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0060056 | mammary gland involution |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0003700 | DNA-binding transcription factor activity |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:1990837 | sequence-specific double-stranded DNA binding |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| InterPro
|
InterPro name |
|---|---|
| IPR000418 | Ets domain |
| IPR003118 | Pointed domain |
| IPR013761 | Sterile alpha motif/pointed domain superfamily |
| IPR036388 | Winged helix-like DNA-binding domain superfamily |
| IPR036390 | Winged helix DNA-binding domain superfamily |
| IPR042693 | ETS-related transcription factor Elf-3, pointed domain |
| IPR046328 | ETS family |
| Pfam
|
Pfam name |
|---|---|
| PF00178 | Ets-domain |
| PF02198 | Sterile alpha motif (SAM)/Pointed domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1912408 | Pre-NOTCH Transcription and Translation | Leaf | R-HSA-162582 | Signal Transduction |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:10391676 |
| Cytoplasm | ECO:0000269 | PubMed:15169914 |
| Cytoplasm | ECO:0000269 | PubMed:17060315 |
| Nucleus | ECO:0000255 | PubMed:10391676 |
| Nucleus | ECO:0000255 | PubMed:15169914 |
| Nucleus | ECO:0000255 | PubMed:17060315 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| appendix | endocrine cells | Medium | Enhanced |
| appendix | enterocytes | Medium | Enhanced |
| appendix | goblet cells | Medium | Enhanced |
| bronchus | ciliated cells (cell body) | High | Enhanced |
| bronchus | goblet cells | High | Enhanced |
| cervix | glandular cells | Low | Enhanced |
| colon | endocrine cells | Medium | Enhanced |
| colon | enterocytes | Medium | Enhanced |
| colon | goblet cells | Medium | Enhanced |
| duodenum | endocrine cells | Medium | Enhanced |
| duodenum | enterocytes | Medium | Enhanced |
| duodenum | enterocytes - Gradient | Descending | Enhanced |
| duodenum | goblet cells | Medium | Enhanced |
| duodenum | paneth cells | Medium | Enhanced |
| endometrium 1 | glandular cells | High | Enhanced |
| fallopian tube | ciliated cells (cell body) | Low | Enhanced |
| fallopian tube | non-ciliated cells | Low | Enhanced |
| gallbladder | glandular cells | Medium | Enhanced |
| kidney | collecting ducts | Low | Enhanced |
| kidney | distal tubules | Low | Enhanced |
| nasopharynx | ciliated cells (cell body) | High | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| pancreas | exocrine glandular cells | Low | Enhanced |
| parathyroid gland | glandular cells | Low | Enhanced |
| placenta | syncytiotrophoblasts - cell body | Medium | Enhanced |
| rectum | endocrine cells | Medium | Enhanced |
| rectum | enterocytes | Medium | Enhanced |
| rectum | goblet cells | Medium | Enhanced |
| salivary gland | glandular cells | Medium | Enhanced |
| seminal vesicle | glandular cells | Low | Enhanced |
| small intestine | endocrine cells | Medium | Enhanced |
| small intestine | enterocytes | Medium | Enhanced |
| small intestine | enterocytes - Gradient | Descending | Enhanced |
| small intestine | goblet cells | Medium | Enhanced |
| small intestine | paneth cells | Medium | Enhanced |
| stomach 1 | glandular cells | Low | Enhanced |
| stomach 2 | glandular cells | Medium | Enhanced |
| tonsil | squamous epithelial cells | High | Enhanced |
| urinary bladder | urothelial cells | High | Enhanced |
| vagina | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|