MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.5.1.23	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides; ceramidase
3.5.1.60	Hydrolases; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides; N-(long-chain-acyl)ethanolamine deacylase

PDB	Resolution (Å)	PDB name
6DXW	2.3	Human N-acylethanolamine-hydrolyzing acid amidase (NAAA) precursor (C126A)
6DXX	2.7	Human N-acylethanolamine-hydrolyzing acid amidase (NAAA) in complex with non-covalent benzothiazole-piperazine inhibitor ARN19702, in presence of Triton X-100

GO ontology	GO term	GO description
Biological Process	GO:0070291	N-acylethanolamine metabolic process
Biological Process	GO:0070292	N-acylphosphatidylethanolamine metabolic process
Biological Process	GO:0006631	fatty acid metabolic process
Biological Process	GO:0016042	lipid catabolic process
Biological Process	GO:0006670	sphingosine metabolic process
Molecular Function	GO:0140297	DNA-binding transcription factor binding
Molecular Function	GO:0047412	N-(long-chain-acyl)ethanolamine deacylase activity
Molecular Function	GO:0017040	N-acylsphingosine amidohydrolase activity
Molecular Function	GO:0102121	ceramidase activity
Molecular Function	GO:0017064	fatty acid amide hydrolase activity
Molecular Function	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0019898	extrinsic component of membrane
Cellular Component	GO:0043202	lysosomal lumen
Cellular Component	GO:0005764	lysosome

InterPro	InterPro name
IPR016699	Acid ceramidase-like
IPR029130	Acid ceramidase, N-terminal
IPR029132	Choloylglycine hydrolase/NAAA C-terminal

Pfam	Pfam name
PF02275	Linear amide C-N hydrolases, choloylglycine hydrolase family
PF15508	beta subunit of N-acylethanolamine-hydrolyzing acid amidase

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-112310	Neurotransmitter release cycle	Internal node	R-HSA-112316	Neuronal System

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	Low	Approved
appendix	glandular cells	Low	Approved
bone marrow	hematopoietic cells	Low	Approved
breast	adipocytes	Medium	Approved
breast	glandular cells	Low	Approved
caudate	neuronal cells	Low	Approved
cerebral cortex	neuronal cells	Low	Approved
colon	glandular cells	Medium	Approved
duodenum	glandular cells	Medium	Approved
endometrium 1	glandular cells	Medium	Approved
endometrium 2	glandular cells	Medium	Approved
fallopian tube	ciliated cells (cell body)	Low	Approved
fallopian tube	non-ciliated cells	Low	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Low	Approved
kidney	cells in tubules	Medium	Approved
liver	hepatocytes	Medium	Approved
lung	macrophages	High	Approved
lymph node	germinal center cells	Low	Approved
lymph node	non-germinal center cells	Medium	Approved
oral mucosa	squamous epithelial cells	Low	Approved
pancreas	exocrine glandular cells	Medium	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
placenta	decidual cells	Low	Approved
prostate	glandular cells	Medium	Approved
rectum	glandular cells	Low	Approved
salivary gland	glandular cells	Low	Approved
seminal vesicle	glandular cells	Medium	Approved
small intestine	glandular cells	Medium	Approved
spleen	cells in red pulp	Low	Approved
spleen	cells in white pulp	Low	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Low	Approved
testis	Leydig cells	Medium	Approved
thyroid gland	glandular cells	Low	Approved
tonsil	non-germinal center cells	Medium	Approved