Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.5.1.18
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date);
glutathione transferase
4.4.1.20
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date);
leukotriene-C4 synthase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 4GTU | 3.3 | LIGAND-FREE HOMODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M4-4 |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0042759 | long-chain fatty acid biosynthetic process |
| Biological Process | GO:0018916 | nitrobenzene metabolic process |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0043295 | glutathione binding |
| Molecular Function | GO:0004364 | glutathione transferase activity |
| Molecular Function | GO:0004464 | leukotriene-C4 synthase activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0045171 | intercellular bridge |
| InterPro
|
InterPro name |
|---|---|
| IPR003081 | Glutathione S-transferase, Mu class |
| IPR004045 | Glutathione S-transferase, N-terminal |
| IPR004046 | Glutathione S-transferase, C-terminal |
| IPR010987 | Glutathione S-transferase, C-terminal-like |
| IPR036249 | Thioredoxin-like superfamily |
| IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
| IPR040079 | Glutathione transferase family |
| Pfam
|
Pfam name |
|---|---|
| PF02798 | Glutathione S-transferase, N-terminal domain |
| PF14497 | Glutathione S-transferase, C-terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-156590 | Glutathione conjugation | Internal node | R-HSA-1430728 | Metabolism |
| R-HSA-9026762 | Biosynthesis of maresin conjugates in tissue regeneration (MCTR) | Leaf | R-HSA-1430728 | Metabolism |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000305 | PubMed:8373352 |