Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.5.1.18
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date);
glutathione transferase
4.4.1.20
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date);
leukotriene-C4 synthase
PDB | Resolution (Å) | PDB name |
---|---|---|
4GTU | 3.3 | LIGAND-FREE HOMODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M4-4 |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0006749 | glutathione metabolic process |
Biological Process | GO:0042759 | long-chain fatty acid biosynthetic process |
Biological Process | GO:0018916 | nitrobenzene metabolic process |
Biological Process | GO:0042178 | xenobiotic catabolic process |
Molecular Function | GO:0019899 | enzyme binding |
Molecular Function | GO:0043295 | glutathione binding |
Molecular Function | GO:0004364 | glutathione transferase activity |
Molecular Function | GO:0004464 | leukotriene-C4 synthase activity |
Molecular Function | GO:0042803 | protein homodimerization activity |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0045171 | intercellular bridge |
InterPro | InterPro name |
---|---|
IPR003081 | Glutathione S-transferase, Mu class |
IPR004045 | Glutathione S-transferase, N-terminal |
IPR004046 | Glutathione S-transferase, C-terminal |
IPR010987 | Glutathione S-transferase, C-terminal-like |
IPR036249 | Thioredoxin-like superfamily |
IPR036282 | Glutathione S-transferase, C-terminal domain superfamily |
IPR040079 | Glutathione transferase family |
Pfam | Pfam name |
---|---|
PF02798 | Glutathione S-transferase, N-terminal domain |
PF14497 | Glutathione S-transferase, C-terminal domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-156590 | Glutathione conjugation | Internal node | R-HSA-1430728 | Metabolism |
R-HSA-9026762 | Biosynthesis of maresin conjugates in tissue regeneration (MCTR) | Leaf | R-HSA-1430728 | Metabolism |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm | ECO:0000305 | PubMed:8373352 |