MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
1LJ2	2.38	Recognition of eIF4G by Rotavirus NSP3 reveals a basis for mRNA circularization
1UG3	2.24	C-terminal portion of human eIF4GI
2W97	2.29	Crystal Structure of eIF4E Bound to Glycerol and eIF4G1 peptide
4AZA	2.16	Improved eIF4E binding peptides by phage display guided design.
4F02	2.0	Crystal structure of the PABP-binding site of eIF4G in complex with RRM1-2 of PABP and poly(A)
5EHC	2.4	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
5EI3	1.71	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
5EIR	2.69	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor.
5T46	1.53	Crystal structure of the human eIF4E-eIF4G complex
5ZK5	2.25	Stapled-peptides tailored against initiation of translation
6ZMW	3.7	Structure of a human 48S translational initiation complex

GO term

GO ontology	GO term	GO description
Biological Process	GO:0001662	behavioral fear response
Biological Process	GO:0002191	cap-dependent translational initiation
Biological Process	GO:0031669	cellular response to nutrient levels
Biological Process	GO:0097009	energy homeostasis
Biological Process	GO:0030324	lung development
Biological Process	GO:0009059	macromolecule biosynthetic process
Biological Process	GO:0035278	miRNA-mediated gene silencing by inhibition of translation
Biological Process	GO:0010507	negative regulation of autophagy
Biological Process	GO:1901215	negative regulation of neuron death
Biological Process	GO:0010801	negative regulation of peptidyl-threonine phosphorylation
Biological Process	GO:0030182	neuron differentiation
Biological Process	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
Biological Process	GO:0010942	positive regulation of cell death
Biological Process	GO:0030307	positive regulation of cell growth
Biological Process	GO:1905537	positive regulation of eukaryotic translation initiation factor 4F complex assembly
Biological Process	GO:1905612	positive regulation of mRNA cap binding
Biological Process	GO:0045666	positive regulation of neuron differentiation
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation
Biological Process	GO:0051247	positive regulation of protein metabolic process
Biological Process	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress
Biological Process	GO:0080135	regulation of cellular response to stress
Biological Process	GO:0060964	regulation of miRNA-mediated gene silencing
Biological Process	GO:1905696	regulation of polysome binding
Biological Process	GO:1905606	regulation of presynapse assembly
Biological Process	GO:0006446	regulation of translational initiation
Biological Process	GO:0045471	response to ethanol
Biological Process	GO:0006412	translation
Biological Process	GO:0006413	translational initiation
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0008190	eukaryotic initiation factor 4E binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0003729	mRNA binding
Molecular Function	GO:0060090	molecular adaptor activity
Molecular Function	GO:0008135	translation factor activity, RNA binding
Molecular Function	GO:0003743	translation initiation factor activity
Molecular Function	GO:0031369	translation initiation factor binding
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0010494	cytoplasmic stress granule
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0016281	eukaryotic translation initiation factor 4F complex
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0005844	polysome
Cellular Component	GO:0098794	postsynapse

InterPro / Pfam

InterPro	InterPro name
IPR003307	W2 domain
IPR003890	MIF4G-like, type 3
IPR003891	Initiation factor eIF-4 gamma, MA3
IPR016024	Armadillo-type fold
IPR045208	Initiation factor 4G

Pfam	Pfam name
PF02020	eIF4-gamma/eIF5/eIF2-epsilon
PF02847	MA3 domain
PF02854	MIF4G domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1169408	ISG15 antiviral mechanism	Leaf	R-HSA-168256	Immune System
R-HSA-156827	L13a-mediated translational silencing of Ceruloplasmin expression	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-166208	mTORC1-mediated signalling	Leaf	R-HSA-162582	Signal Transduction
R-HSA-429947	Deadenylation of mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-450408	AUF1 (hnRNP D0) binds and destabilizes mRNA	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-72649	Translation initiation complex formation	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-72662	Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Internal node	R-HSA-392499	Metabolism of proteins
R-HSA-72702	Ribosomal scanning and start codon recognition	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-72706	GTP hydrolysis and joining of the 60S ribosomal subunit	Leaf	R-HSA-392499	Metabolism of proteins
R-HSA-9010553	Regulation of expression of SLITs and ROBOs	Leaf	R-HSA-1266738	Developmental Biology
R-HSA-975956	Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	Leaf	R-HSA-8953854	Metabolism of RNA
R-HSA-975957	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Leaf	R-HSA-8953854	Metabolism of RNA

Subcellular location

Location	ECO term	Pubmed
Cytoplasm	ECO:0000269	PubMed:17984221
Cytoplasm, Stress granule	ECO:0000269	PubMed:22872150
Nucleus	ECO:0000269	PubMed:17984221

Interactor | Variant | Drug

Phenotype

HPO ID	HPO name
HP:0000006	Autosomal dominant inheritance
HP:0000338	Hypomimic face
HP:0000651	Diplopia
HP:0000713	Agitation
HP:0000716	Depression
HP:0000726	Dementia
HP:0000741	Apathy
HP:0000744	Low frustration tolerance
HP:0001268	Mental deterioration
HP:0001300	Parkinsonism
HP:0001332	Dystonia
HP:0001824	Weight loss
HP:0002015	Dysphagia
HP:0002063	Rigidity
HP:0002067	Bradykinesia
HP:0002120	Cerebral cortical atrophy
HP:0002171	Gliosis
HP:0002172	Postural instability
HP:0002304	Akinesia
HP:0002322	Resting tremor
HP:0002359	Frequent falls
HP:0002360	Sleep disturbance
HP:0002362	Shuffling gait
HP:0002367	Visual hallucinations
HP:0002548	Parkinsonism with favorable response to dopaminergic medication
HP:0003394	Muscle spasm
HP:0003584	Late onset
HP:0003587	Insidious onset
HP:0003596	Middle age onset
HP:0004409	Hyposmia
HP:0004926	Orthostatic hypotension due to autonomic dysfunction
HP:0005340	Spastic/hyperactive bladder
HP:0012450	Chronic constipation
HP:0031435	Monotonic speech
HP:0100315	Lewy bodies
HP:0100660	Dyskinesia
HP:0100710	Impulsivity
HP:0100753	Schizophrenia

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Approved
adrenal gland	glandular cells	High	Approved
appendix	glandular cells	High	Approved
appendix	lymphoid tissue	Medium	Approved
bone marrow	hematopoietic cells	High	Approved
breast	glandular cells	High	Approved
breast	myoepithelial cells	Medium	Approved
bronchus	respiratory epithelial cells	Medium	Approved
caudate	glial cells	Low	Approved
caudate	neuronal cells	Low	Approved
cerebellum	Purkinje cells	High	Approved
cerebellum	cells in granular layer	Medium	Approved
cerebellum	cells in molecular layer	Medium	Approved
cerebral cortex	endothelial cells	Low	Approved
cerebral cortex	glial cells	Low	Approved
cerebral cortex	neuronal cells	High	Approved
cervix	glandular cells	Medium	Approved
cervix	squamous epithelial cells	High	Approved
colon	endothelial cells	Low	Approved
colon	glandular cells	High	Approved
colon	peripheral nerve/ganglion	Medium	Approved
duodenum	glandular cells	High	Approved
endometrium 1	cells in endometrial stroma	Medium	Approved
endometrium 1	glandular cells	High	Approved
endometrium 2	glandular cells	High	Approved
epididymis	glandular cells	High	Approved
esophagus	squamous epithelial cells	High	Approved
fallopian tube	glandular cells	High	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Low	Approved
hippocampus	neuronal cells	Low	Approved
kidney	cells in glomeruli	Medium	Approved
kidney	cells in tubules	Medium	Approved
liver	cholangiocytes	Low	Approved
liver	hepatocytes	Medium	Approved
lung	alveolar cells type I	Low	Approved
lung	alveolar cells type II	Medium	Approved
lung	macrophages	Low	Approved
lymph node	germinal center cells	High	Approved
lymph node	non-germinal center cells	High	Approved
nasopharynx	respiratory epithelial cells	Medium	Approved
oral mucosa	squamous epithelial cells	High	Approved
ovary	ovarian stroma cells	Low	Approved
pancreas	exocrine glandular cells	High	Approved
pancreas	pancreatic endocrine cells	Medium	Approved
parathyroid gland	glandular cells	Medium	Approved
placenta	decidual cells	High	Approved
placenta	trophoblastic cells	High	Approved
prostate	glandular cells	High	Approved
rectum	glandular cells	High	Approved
salivary gland	glandular cells	Medium	Approved
seminal vesicle	glandular cells	Medium	Approved
skeletal muscle	myocytes	Medium	Approved
skin 1	Langerhans	Low	Approved
skin 1	fibroblasts	Medium	Approved
skin 1	keratinocytes	Medium	Approved
skin 1	melanocytes	Medium	Approved
skin 2	epidermal cells	High	Approved
small intestine	glandular cells	High	Approved
smooth muscle	smooth muscle cells	Medium	Approved
soft tissue 1	fibroblasts	Medium	Approved
soft tissue 2	fibroblasts	Medium	Approved
spleen	cells in red pulp	Medium	Approved
spleen	cells in white pulp	Medium	Approved
stomach 1	glandular cells	High	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Medium	Approved
testis	cells in seminiferous ducts	Medium	Approved
thyroid gland	glandular cells	Medium	Approved
tonsil	germinal center cells	High	Approved
tonsil	non-germinal center cells	High	Approved
tonsil	squamous epithelial cells	High	Approved
urinary bladder	urothelial cells	Medium	Approved
vagina	squamous epithelial cells	High	Approved

Summary of Q04637

Gene: EIF4G1, EIF4F, EIF4G, EIF4GI
Protein: Eukaryotic translation initiation factor 4 gamma 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q04637

Gene: EIF4G1, EIF4F, EIF4G, EIF4GI Protein: Eukaryotic translation initiation factor 4 gamma 1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: EIF4G1, EIF4F, EIF4G, EIF4GI
Protein: Eukaryotic translation initiation factor 4 gamma 1