MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.1.1.-	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor;
1.1.1.112	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; indanol dehydrogenase
1.1.1.149	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 20α-hydroxysteroid dehydrogenase
1.1.1.209	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3(or 17)α-hydroxysteroid dehydrogenase
1.1.1.210	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3α(or 20β)-hydroxysteroid dehydrogenase
1.1.1.357	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3α-hydroxysteroid 3-dehydrogenase
1.1.1.51	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3(or 17)α-hydroxysteroid dehydrogenase
1.1.1.53	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 3α(or 20β)-hydroxysteroid dehydrogenase
1.1.1.62	Oxidoreductases; Acting on the CH-OH group of donors; With NAD+ or NADP+ as acceptor; 17β-estradiol 17-dehydrogenase
1.3.1.20	Oxidoreductases; Acting on the CH-CH group of donors; With NAD+ or NADP+ as acceptor; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

Structure

PDB	Resolution (Å)	PDB name
1MRQ	1.59	Crystal structure of human 20alpha-HSD in ternary complex with NADP and 20alpha-hydroxy-progesterone
3C3U	1.8	Crystal structure of AKR1C1 in complex with NADP and 3,5-dichlorosalicylic acid
3GUG	1.9	Crystal structure of AKR1C1 L308V mutant in complex with NADP and 3,5-dichlorosalicylic acid
3NTY	1.87	Crystal structure of AKR1C1 in complex with NADP and 5-Phenyl,3-chlorosalicylic acid
4YVP	2.6	Crystal Structure of AKR1C1 complexed with glibenclamide
6A7A	2.37	AKR1C1 complexed with new inhibitor with novel scaffold
6IJX	2.2	Crystal Structure of AKR1C1 complexed with meclofenamic acid

GO term

GO ontology	GO term	GO description
Biological Process	GO:0015721	bile acid and bile salt transport
Biological Process	GO:0008206	bile acid metabolic process
Biological Process	GO:0071395	cellular response to jasmonic acid stimulus
Biological Process	GO:0042632	cholesterol homeostasis
Biological Process	GO:0044597	daunorubicin metabolic process
Biological Process	GO:0007586	digestion
Biological Process	GO:0044598	doxorubicin metabolic process
Biological Process	GO:0030855	epithelial cell differentiation
Biological Process	GO:0030299	intestinal cholesterol absorption
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process
Biological Process	GO:0042448	progesterone metabolic process
Biological Process	GO:0006693	prostaglandin metabolic process
Biological Process	GO:0046683	response to organophosphorus
Biological Process	GO:0042574	retinal metabolic process
Biological Process	GO:0001523	retinoid metabolic process
Biological Process	GO:0006805	xenobiotic metabolic process
Molecular Function	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity
Molecular Function	GO:0044594	17-beta-hydroxysteroid dehydrogenase (NAD+) activity
Molecular Function	GO:0033703	3beta-hydroxy-5beta-steroid dehydrogenase activity
Molecular Function	GO:0047024	5alpha-androstane-3beta,17beta-diol dehydrogenase activity
Molecular Function	GO:0004032	alditol:NADP+ 1-oxidoreductase activity
Molecular Function	GO:0004033	aldo-keto reductase (NADP) activity
Molecular Function	GO:0047044	androstan-3-alpha,17-beta-diol dehydrogenase activity
Molecular Function	GO:0047042	androsterone dehydrogenase (B-specific) activity
Molecular Function	GO:0047023	androsterone dehydrogenase activity
Molecular Function	GO:0032052	bile acid binding
Molecular Function	GO:0031406	carboxylic acid binding
Molecular Function	GO:0035410	dihydrotestosterone 17-beta-dehydrogenase activity
Molecular Function	GO:0004303	estradiol 17-beta-dehydrogenase NAD(P) activity
Molecular Function	GO:0047718	indanol dehydrogenase activity
Molecular Function	GO:0047086	ketosteroid monooxygenase activity
Molecular Function	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Molecular Function	GO:0018636	phenanthrene 9,10-monooxygenase activity
Molecular Function	GO:0033764	steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Molecular Function	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity
Molecular Function	GO:003028	testosterone dehydrogenase NAD(P) activity
Molecular Function	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome

InterPro / Pfam

InterPro	InterPro name
IPR018170	Aldo/keto reductase, conserved site
IPR020471	Aldo-keto reductase
IPR023210	NADP-dependent oxidoreductase domain
IPR036812	NADP-dependent oxidoreductase domain superfamily
IPR044482	Aldo-keto reductase family 1 member C

Pfam	Pfam name
PF00248	Aldo/keto reductase family

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-193368	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Leaf	R-HSA-1430728	Metabolism
R-HSA-193775	Synthesis of bile acids and bile salts via 24-hydroxycholesterol	Leaf	R-HSA-1430728	Metabolism
R-HSA-193807	Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Leaf	R-HSA-1430728	Metabolism
R-HSA-975634	Retinoid metabolism and transport	Leaf	R-HSA-9709957	Sensory Perception
R-HSA-9757110	Prednisone ADME	Leaf	R-HSA-9748784	Drug ADME

Subcellular location

Location	ECO term	Pubmed
Cytoplasm, cytosol	ECO:0000269	PubMed:8486699

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Enhanced
adrenal gland	glandular cells	Low	Enhanced
bone marrow	hematopoietic cells	Medium	Enhanced
breast	adipocytes	Medium	Enhanced
bronchus	respiratory epithelial cells	High	Enhanced
caudate	neuronal cells	Low	Enhanced
cerebellum	cells in molecular layer	Low	Enhanced
cervix	glandular cells	Low	Enhanced
colon	endothelial cells	Medium	Enhanced
colon	glandular cells	Low	Enhanced
colon	peripheral nerve/ganglion	Low	Enhanced
duodenum	glandular cells	Medium	Enhanced
esophagus	squamous epithelial cells	Low	Enhanced
fallopian tube	glandular cells	Medium	Enhanced
gallbladder	glandular cells	Low	Enhanced
heart muscle	cardiomyocytes	Low	Enhanced
hippocampus	glial cells	Low	Enhanced
hippocampus	neuronal cells	Medium	Enhanced
kidney	proximal tubules (cell body)	High	Enhanced
liver	cholangiocytes	Medium	Enhanced
liver	hepatocytes	High	Enhanced
nasopharynx	respiratory epithelial cells	Medium	Enhanced
oral mucosa	squamous epithelial cells	Medium	Enhanced
pancreas	exocrine glandular cells	High	Enhanced
rectum	glandular cells	Low	Enhanced
salivary gland	glandular cells	Low	Enhanced
skeletal muscle	myocytes	Medium	Enhanced
skin 1	fibrohistiocytic cells	Medium	Enhanced
skin 2	cells in spinous layer	Low	Enhanced
skin 2	fibrohistiocytic cells	Medium	Enhanced
skin 2	hair follicles	Low	Enhanced
small intestine	glandular cells	High	Enhanced
soft tissue 1	fibroblasts	Low	Enhanced
soft tissue 2	chondrocytes	Medium	Enhanced
soft tissue 2	fibroblasts	Medium	Enhanced
stomach 1	glandular cells	High	Enhanced
stomach 2	glandular cells	High	Enhanced
testis	Leydig cells	High	Enhanced
testis	cells in seminiferous ducts	Low	Enhanced
tonsil	germinal center cells	Low	Enhanced
tonsil	squamous epithelial cells	Medium	Enhanced
urinary bladder	urothelial cells	High	Enhanced

Disease

Summary of Q04828

Gene: AKR1C1, DDH, DDH1
Protein: Aldo-keto reductase family 1 member C1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q04828

Gene: AKR1C1, DDH, DDH1 Protein: Aldo-keto reductase family 1 member C1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: AKR1C1, DDH, DDH1
Protein: Aldo-keto reductase family 1 member C1