MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2C63	2.15	14-3-3 Protein Eta (Human) Complexed to Peptide
2C74	2.7	14-3-3 Protein Eta (Human) Complexed to Peptide
7NMZ	2.303	Structure of 14-3-3 eta in complex with Nedd4-2(335-455) containing two 14-3-3 binding motifs Ser342 and Ser448

GO term

GO ontology	GO term	GO description
Biological Process	GO:0006713	glucocorticoid catabolic process
Biological Process	GO:0042921	glucocorticoid receptor signaling pathway
Biological Process	GO:0006886	intracellular protein transport
Biological Process	GO:0086010	membrane depolarization during action potential
Biological Process	GO:0050774	negative regulation of dendrite morphogenesis
Biological Process	GO:0045893	positive regulation of DNA-templated transcription
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission
Biological Process	GO:0045664	regulation of neuron differentiation
Biological Process	GO:2000649	regulation of sodium ion transmembrane transporter activity
Biological Process	GO:0002028	regulation of sodium ion transport
Biological Process	GO:0048167	regulation of synaptic plasticity
Biological Process	GO:0007165	signal transduction
Biological Process	GO:0021762	substantia nigra development
Molecular Function	GO:0003779	actin binding
Molecular Function	GO:0019899	enzyme binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0005159	insulin-like growth factor receptor binding
Molecular Function	GO:0035259	nuclear glucocorticoid receptor binding
Molecular Function	GO:0019904	protein domain specific binding
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0017080	sodium channel regulator activity
Molecular Function	GO:0044325	transmembrane transporter binding
Cellular Component	GO:0150048	cerebellar granule cell to Purkinje cell synapse
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Cellular Component	GO:0014704	intercalated disc
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0098793	presynapse

InterPro / Pfam

InterPro	InterPro name
IPR000308	14-3-3 protein
IPR023409	14-3-3 protein, conserved site
IPR023410	14-3-3 domain
IPR036815	14-3-3 domain superfamily

Pfam	Pfam name
PF00244	14-3-3 protein

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-111447	Activation of BAD and translocation to mitochondria	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-5625740	RHO GTPases activate PKNs	Internal node	R-HSA-162582	Signal Transduction
R-HSA-5628897	TP53 Regulates Metabolic Genes	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-75035	Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Leaf	R-HSA-1640170	Cell Cycle
R-HSA-9735871	SARS-CoV-1 targets host intracellular signalling and regulatory pathways	Leaf	R-HSA-1643685	Disease
R-HSA-9755779	SARS-CoV-2 targets host intracellular signalling and regulatory pathways	Leaf	R-HSA-1643685	Disease

Summary of Q04917

Gene: YWHAH, YWHA1
Protein: 14-3-3 protein eta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q04917

Gene: YWHAH, YWHA1 Protein: 14-3-3 protein eta

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: YWHAH, YWHA1
Protein: 14-3-3 protein eta