MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
3.1.1.23	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; acylglycerol lipase
3.1.1.79	Hydrolases; Acting on ester bonds; Carboxylic-ester hydrolases; hormone-sensitive lipase

GO ontology	GO term	GO description
Biological Process	GO:0008203	cholesterol metabolic process
Biological Process	GO:0046340	diacylglycerol catabolic process
Biological Process	GO:0046485	ether lipid metabolic process
Biological Process	GO:0016042	lipid catabolic process
Biological Process	GO:0006468	protein phosphorylation
Biological Process	GO:0019433	triglyceride catabolic process
Molecular Function	GO:0102259	1,2-diacylglycerol acylhydrolase activity
Molecular Function	GO:0102258	1,3-diacylglycerol acylhydrolase activity
Molecular Function	GO:0047372	acylglycerol lipase activity
Molecular Function	GO:0047376	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
Molecular Function	GO:0033878	hormone-sensitive lipase activity
Molecular Function	GO:0050253	retinyl-palmitate esterase activity
Molecular Function	GO:0004771	sterol esterase activity
Molecular Function	GO:0004806	triglyceride lipase activity
Cellular Component	GO:0005901	caveola
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005811	lipid droplet
Cellular Component	GO:0016020	membrane

InterPro	InterPro name
IPR002168	Lipase, GDXG, putative histidine active site
IPR010468	Hormone-sensitive lipase, N-terminal
IPR013094	Alpha/beta hydrolase fold-3
IPR029058	Alpha/Beta hydrolase fold
IPR033140	Lipase, GDXG, putative serine active site

Pfam	Pfam name
PF06350	Hormone-sensitive lipase (HSL) N-terminus
PF07859	alpha/beta hydrolase fold

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-163560	Triglyceride catabolism	Leaf	R-HSA-1430728	Metabolism

HPO ID	HPO name
HP:0000007	Autosomal recessive inheritance
HP:0000147	Polycystic ovaries
HP:0000468	Increased adipose tissue around the neck
HP:0000819	Diabetes mellitus
HP:0000822	Hypertension
HP:0000831	Insulin-resistant diabetes mellitus
HP:0000855	Insulin resistance
HP:0000876	Oligomenorrhea
HP:0000956	Acanthosis nigricans
HP:0001010	Hypopigmentation of the skin
HP:0001324	Muscle weakness
HP:0001397	Hepatic steatosis
HP:0001761	Pes cavus
HP:0002155	Hypertriglyceridemia
HP:0002240	Hepatomegaly
HP:0002938	Lumbar hyperlordosis
HP:0003077	Hyperlipidemia
HP:0003119	Abnormal circulating lipid concentration
HP:0003198	Myopathy
HP:0003202	Skeletal muscle atrophy
HP:0003236	Elevated circulating creatine kinase concentration
HP:0003292	Decreased serum leptin
HP:0003551	Difficulty climbing stairs
HP:0003560	Muscular dystrophy
HP:0003635	Loss of subcutaneous adipose tissue in limbs
HP:0003701	Proximal muscle weakness
HP:0003712	Skeletal muscle hypertrophy
HP:0007340	Lower limb muscle weakness
HP:0008993	Increased intraabdominal fat
HP:0008994	Proximal muscle weakness in lower limbs
HP:0008997	Proximal muscle weakness in upper limbs
HP:0009017	Loss of gluteal subcutaneous adipose tissue
HP:0009125	Lipodystrophy
HP:0011462	Young adult onset
HP:0012743	Abdominal obesity
HP:0012881	Abnormal labia majora morphology
HP:0030685	Decreased adiponectin level

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	High	Enhanced
appendix	endocrine cells	Medium	Enhanced
appendix	enterocytes	Medium	Enhanced
appendix	goblet cells	Medium	Enhanced
breast	adipocytes	High	Enhanced
colon	endocrine cells	Medium	Enhanced
colon	enterocytes	Low	Enhanced
colon	goblet cells	Low	Enhanced
colon	mucosal lymphoid cells	Low	Enhanced
duodenum	endocrine cells	Medium	Enhanced
duodenum	enterocytes	Low	Enhanced
duodenum	goblet cells	Low	Enhanced
rectum	endocrine cells	Medium	Enhanced
rectum	enterocytes	Medium	Enhanced
rectum	goblet cells	Low	Enhanced
small intestine	endocrine cells	Medium	Enhanced
small intestine	enterocytes	Medium	Enhanced
small intestine	enterocytes - Microvilli	Medium	Enhanced
small intestine	goblet cells	Medium	Enhanced
testis	elongated or late spermatids	High	Enhanced
testis	pachytene spermatocytes	Low	Enhanced
testis	round or early spermatids	Medium	Enhanced