Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.7.10.2
Transferases;
Transferring phosphorus-containing groups;
Protein-tyrosine kinases;
non-specific protein-tyrosine kinase
2.7.11.13
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
protein kinase C
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0042100 | B cell proliferation |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| Biological Process | GO:0032147 | activation of protein kinase activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0060326 | cell chemotaxis |
| Biological Process | GO:0007049 | cell cycle |
| Biological Process | GO:0034644 | cellular response to UV |
| Biological Process | GO:1904385 | cellular response to angiotensin |
| Biological Process | GO:0070301 | cellular response to hydrogen peroxide |
| Biological Process | GO:0071447 | cellular response to hydroperoxide |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0042742 | defense response to bacterium |
| Biological Process | GO:0016064 | immunoglobulin mediated immune response |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process | GO:0043407 | negative regulation of MAP kinase activity |
| Biological Process | GO:0030837 | negative regulation of actin filament polymerization |
| Biological Process | GO:0051490 | negative regulation of filopodium assembly |
| Biological Process | GO:0034351 | negative regulation of glial cell apoptotic process |
| Biological Process | GO:0050728 | negative regulation of inflammatory response |
| Biological Process | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| Biological Process | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation |
| Biological Process | GO:0090331 | negative regulation of platelet aggregation |
| Biological Process | GO:0032091 | negative regulation of protein binding |
| Biological Process | GO:0042119 | neutrophil activation |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:0018107 | peptidyl-threonine phosphorylation |
| Biological Process | GO:2001235 | positive regulation of apoptotic signaling pathway |
| Biological Process | GO:2000304 | positive regulation of ceramide biosynthetic process |
| Biological Process | GO:0032079 | positive regulation of endodeoxyribonuclease activity |
| Biological Process | GO:2000753 | positive regulation of glucosylceramide catabolic process |
| Biological Process | GO:1900163 | positive regulation of phospholipid scramblase activity |
| Biological Process | GO:0035307 | positive regulation of protein dephosphorylation |
| Biological Process | GO:0042307 | positive regulation of protein import into nucleus |
| Biological Process | GO:2000755 | positive regulation of sphingomyelin catabolic process |
| Biological Process | GO:0032930 | positive regulation of superoxide anion generation |
| Biological Process | GO:0043687 | post-translational protein modification |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0032956 | regulation of actin cytoskeleton organization |
| Biological Process | GO:2000303 | regulation of ceramide biosynthetic process |
| Biological Process | GO:0043488 | regulation of mRNA stability |
| Biological Process | GO:0010469 | regulation of signaling receptor activity |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0023021 | termination of signal transduction |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004698 | calcium-dependent protein kinase C activity |
| Molecular Function | GO:0004699 | calcium-independent protein kinase C activity |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0043560 | insulin receptor substrate binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| Molecular Function | GO:0004697 | protein kinase C activity |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0036019 | endolysosome |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0016363 | nuclear matrix |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000008 | C2 domain |
| IPR000719 | Protein kinase domain |
| IPR000961 | AGC-kinase, C-terminal |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| IPR008271 | Serine/threonine-protein kinase, active site |
| IPR011009 | Protein kinase-like domain superfamily |
| IPR014376 | Protein kinase C, delta/epsilon/eta/theta types |
| IPR017441 | Protein kinase, ATP binding site |
| IPR017892 | Protein kinase, C-terminal |
| IPR020454 | Diacylglycerol/phorbol-ester binding |
| IPR027436 | Protein kinase C, delta |
| IPR034667 | Novel protein kinase C delta, catalytic domain |
| IPR035892 | C2 domain superfamily |
| IPR046349 | C1-like domain superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF00069 | Protein kinase domain |
| PF00130 | Phorbol esters/diacylglycerol binding domain (C1 domain) |
| PF00433 | Protein kinase C terminal domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-111465 | Apoptotic cleavage of cellular proteins | Internal node | R-HSA-5357801 | Programmed Cell Death |
| R-HSA-111933 | Calmodulin induced events | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-114508 | Effects of PIP2 hydrolysis | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-1250196 | SHC1 events in ERBB2 signaling | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-1489509 | DAG and IP3 signaling | Internal node | R-HSA-162582 | Signal Transduction |
| R-HSA-2029485 | Role of phospholipids in phagocytosis | Leaf | R-HSA-168256 | Immune System |
| R-HSA-418597 | G alpha (z) signalling events | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA | Leaf | R-HSA-8953854 | Metabolism of RNA |
| R-HSA-5218921 | VEGFR2 mediated cell proliferation | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-5607764 | CLEC7A (Dectin-1) signaling | Internal node | R-HSA-168256 | Immune System |
| R-HSA-5668599 | RHO GTPases Activate NADPH Oxidases | Leaf | R-HSA-162582 | Signal Transduction |
| R-HSA-6798695 | Neutrophil degranulation | Leaf | R-HSA-168256 | Immune System |
| R-HSA-877300 | Interferon gamma signaling | Internal node | R-HSA-168256 | Immune System |
| R-HSA-9755511 | KEAP1-NFE2L2 pathway | Internal node | R-HSA-8953897 | Cellular responses to stimuli |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell membrane | ECO:0000269 | PubMed:17303575 |
| Cell membrane | ECO:0000269 | PubMed:17603046 |
| Cytoplasm | ECO:0000269 | PubMed:15774464 |
| Cytoplasm | ECO:0000269 | PubMed:17303575 |
| Cytoplasm | ECO:0000269 | PubMed:17603046 |
| Cytoplasm | ECO:0000269 | PubMed:18285462 |
| Cytoplasm, perinuclear region | ECO:0000269 | PubMed:12649167 |
| Cytoplasm, perinuclear region | ECO:0000269 | PubMed:15774464 |
| Cytoplasm, perinuclear region | ECO:0000269 | PubMed:17603046 |
| Endomembrane system | ECO:0000269 | PubMed:17303575 |
| Mitochondrion | ECO:0000269 | PubMed:12649167 |
| Nucleus | ECO:0000269 | PubMed:15774464 |
| Nucleus | ECO:0000269 | PubMed:17603046 |
| Nucleus | ECO:0000269 | PubMed:18285462 |
| HPO ID
|
HPO name |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000010 | Recurrent urinary tract infections |
| HP:0000083 | Renal insufficiency |
| HP:0000099 | Glomerulonephritis |
| HP:0000100 | Nephrotic syndrome |
| HP:0000248 | Brachycephaly |
| HP:0000388 | Otitis media |
| HP:0000389 | Chronic otitis media |
| HP:0000403 | Recurrent otitis media |
| HP:0000554 | Uveitis |
| HP:0000854 | Thyroid adenoma |
| HP:0000978 | Bruising susceptibility |
| HP:0000979 | Purpura |
| HP:0001025 | Urticaria |
| HP:0001250 | Seizure |
| HP:0001369 | Arthritis |
| HP:0001392 | Abnormality of the liver |
| HP:0001402 | Hepatocellular carcinoma |
| HP:0001433 | Hepatosplenomegaly |
| HP:0001531 | Failure to thrive in infancy |
| HP:0001596 | Alopecia |
| HP:0001744 | Splenomegaly |
| HP:0001789 | Hydrops fetalis |
| HP:0001878 | Hemolytic anemia |
| HP:0001880 | Eosinophilia |
| HP:0001888 | Lymphopenia |
| HP:0001890 | Autoimmune hemolytic anemia |
| HP:0001892 | Abnormal bleeding |
| HP:0001904 | Neutropenia in presence of anti-neutropil antibodies |
| HP:0001923 | Reticulocytosis |
| HP:0001954 | Recurrent fever |
| HP:0001971 | Hypersplenism |
| HP:0001973 | Autoimmune thrombocytopenia |
| HP:0002023 | Anal atresia |
| HP:0002090 | Pneumonia |
| HP:0002091 | Restrictive ventilatory defect |
| HP:0002097 | Emphysema |
| HP:0002110 | Bronchiectasis |
| HP:0002113 | Pulmonary infiltrates |
| HP:0002205 | Recurrent respiratory infections |
| HP:0002206 | Pulmonary fibrosis |
| HP:0002240 | Hepatomegaly |
| HP:0002315 | Headache |
| HP:0002583 | Colitis |
| HP:0002633 | Vasculitis |
| HP:0002665 | Lymphoma |
| HP:0002671 | Basal cell carcinoma |
| HP:0002716 | Lymphadenopathy |
| HP:0002719 | Recurrent infections |
| HP:0002721 | Immunodeficiency |
| HP:0002725 | Systemic lupus erythematosus |
| HP:0002729 | Follicular hyperplasia |
| HP:0002730 | Chronic noninfectious lymphadenopathy |
| HP:0002783 | Recurrent lower respiratory tract infections |
| HP:0002788 | Recurrent upper respiratory tract infections |
| HP:0002829 | Arthralgia |
| HP:0002837 | Recurrent bronchitis |
| HP:0002848 | Decreased specific anti-polysaccharide antibody level |
| HP:0002850 | Decreased circulating total IgM |
| HP:0002851 | Elevated proportion of CD4-negative, CD8-negative, alpha-beta regulatory T cells |
| HP:0002890 | Thyroid carcinoma |
| HP:0002910 | Elevated hepatic transaminase |
| HP:0002923 | Rheumatoid factor positive |
| HP:0002960 | Autoimmunity |
| HP:0003212 | Increased circulating IgE level |
| HP:0003237 | Increased circulating IgG level |
| HP:0003261 | Increased circulating IgA level |
| HP:0003453 | Antineutrophil antibody positivity |
| HP:0003493 | Antinuclear antibody positivity |
| HP:0003565 | Elevated erythrocyte sedimentation rate |
| HP:0003613 | Antiphospholipid antibody positivity |
| HP:0003774 | Stage 5 chronic kidney disease |
| HP:0004313 | Decreased circulating antibody level |
| HP:0004315 | Decreased circulating IgG level |
| HP:0004844 | Coombs-positive hemolytic anemia |
| HP:0005263 | Gastritis |
| HP:0005404 | Increased B cell count |
| HP:0005407 | Decreased proportion of CD4-positive helper T cells |
| HP:0005421 | Decreased circulating complement C3 concentration |
| HP:0005523 | Lymphoproliferative disorder |
| HP:0005528 | Bone marrow hypocellularity |
| HP:0006783 | Posterior pharyngeal cleft |
| HP:0008069 | Neoplasm of the skin |
| HP:0008209 | Premature ovarian insufficiency |
| HP:0008940 | Generalized lymphadenopathy |
| HP:0010619 | Fibroadenoma of the breast |
| HP:0010702 | Increased circulating antibody level |
| HP:0011107 | Recurrent aphthous stomatitis |
| HP:0011108 | Recurrent sinusitis |
| HP:0011227 | Elevated circulating C-reactive protein concentration |
| HP:0012115 | Hepatitis |
| HP:0012178 | Reduced natural killer cell activity |
| HP:0012189 | Hodgkin lymphoma |
| HP:0012190 | T-cell lymphoma |
| HP:0012191 | B-cell lymphoma |
| HP:0012490 | Panniculitis |
| HP:0012539 | Non-Hodgkin lymphoma |
| HP:0012578 | Membranous nephropathy |
| HP:0020072 | Persistent EBV viremia |
| HP:0020136 | Anticardiolipin IgG antibody positivity |
| HP:0025475 | Erythematous macule |
| HP:0030080 | Burkitt lymphoma |
| HP:0030374 | Decreased proportion of memory B cells |
| HP:0030388 | Decreased proportion of class-switched memory B cells |
| HP:0030782 | Abnormal circulating interleukin concentration |
| HP:0031020 | Bone marrow hypercellularity |
| HP:0031041 | Obstruction of the superior vena cava |
| HP:0031392 | Abnormal proportion of CD4-positive T cells |
| HP:0031393 | Abnormal proportion of CD8-positive T cells |
| HP:0031956 | Elevated circulating aspartate aminotransferase concentration |
| HP:0031964 | Elevated circulating alanine aminotransferase concentration |
| HP:0033207 | Increased proportion autoreactive unresponsive CD21-/low B cells |
| HP:0040126 | Abnormal vitamin B12 level |
| HP:0045042 | Decreased circulating complement C4 concentration |
| HP:0100646 | Thyroiditis |
| HP:0100648 | Neoplasm of the tongue |
| HP:0100721 | Mediastinal lymphadenopathy |
| HP:0100723 | Gastrointestinal stroma tumor |
| HP:0100827 | Lymphocytosis |
| HP:0410293 | Absent isohemagglutinin level |
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Low | Enhanced |
| adrenal gland | glandular cells | Medium | Enhanced |
| appendix | glandular cells | High | Enhanced |
| appendix | lymphoid tissue | High | Enhanced |
| bone marrow | hematopoietic cells | High | Enhanced |
| breast | adipocytes | Low | Enhanced |
| bronchus | respiratory epithelial cells | High | Enhanced |
| caudate | glial cells | Low | Enhanced |
| caudate | neuronal cells | Medium | Enhanced |
| cerebellum | Purkinje cells - cytoplasm/membrane | Medium | Enhanced |
| cerebellum | Purkinje cells - dendrites | Medium | Enhanced |
| cerebellum | granular cells - cytoplasm/membrane | Medium | Enhanced |
| cerebral cortex | endothelial cells | Low | Enhanced |
| cerebral cortex | glial cells | Medium | Enhanced |
| cerebral cortex | neuronal cells | Low | Enhanced |
| cerebral cortex | neuropil | Low | Enhanced |
| cervix | glandular cells | Medium | Enhanced |
| cervix | squamous epithelial cells | Low | Enhanced |
| colon | endothelial cells | Low | Enhanced |
| colon | glandular cells | High | Enhanced |
| colon | peripheral nerve/ganglion | Low | Enhanced |
| duodenum | glandular cells | Medium | Enhanced |
| endometrium 1 | glandular cells | Medium | Enhanced |
| endometrium 2 | glandular cells | High | Enhanced |
| epididymis | glandular cells | High | Enhanced |
| esophagus | squamous epithelial cells | Medium | Enhanced |
| fallopian tube | glandular cells | High | Enhanced |
| gallbladder | glandular cells | High | Enhanced |
| heart muscle | cardiomyocytes | Low | Enhanced |
| hippocampus | glial cells | Low | Enhanced |
| hippocampus | neuronal cells | Low | Enhanced |
| kidney | cells in glomeruli | Medium | Enhanced |
| kidney | cells in tubules | Medium | Enhanced |
| liver | cholangiocytes | Low | Enhanced |
| liver | hepatocytes | Low | Enhanced |
| lung | alveolar cells type I | Medium | Enhanced |
| lung | alveolar cells type II | Medium | Enhanced |
| lung | macrophages | High | Enhanced |
| lymph node | germinal center cells | High | Enhanced |
| lymph node | non-germinal center cells | High | Enhanced |
| nasopharynx | respiratory epithelial cells | Medium | Enhanced |
| oral mucosa | squamous epithelial cells | Medium | Enhanced |
| ovary | follicle cells | Medium | Enhanced |
| ovary | ovarian stroma cells | Low | Enhanced |
| pancreas | exocrine glandular cells | Medium | Enhanced |
| pancreas | pancreatic endocrine cells | Medium | Enhanced |
| parathyroid gland | glandular cells | Medium | Enhanced |
| placenta | cytotrophoblasts | High | Enhanced |
| placenta | hofbauer cells | High | Enhanced |
| placenta | syncytiotrophoblasts - cell body | High | Enhanced |
| placenta | syncytiotrophoblasts - microvilli | Medium | Enhanced |
| prostate | glandular cells | Medium | Enhanced |
| rectum | glandular cells | High | Enhanced |
| salivary gland | glandular cells | Medium | Enhanced |
| seminal vesicle | glandular cells | High | Enhanced |
| skeletal muscle | myocytes | Low | Enhanced |
| skin 1 | Langerhans | Low | Enhanced |
| skin 1 | fibroblasts | Low | Enhanced |
| skin 1 | keratinocytes | Low | Enhanced |
| skin 1 | melanocytes | Low | Enhanced |
| skin 2 | epidermal cells | Low | Enhanced |
| small intestine | glandular cells | Medium | Enhanced |
| smooth muscle | smooth muscle cells | Low | Enhanced |
| soft tissue 1 | chondrocytes | Low | Enhanced |
| soft tissue 1 | fibroblasts | Low | Enhanced |
| soft tissue 2 | fibroblasts | Low | Enhanced |
| spleen | cells in red pulp | Medium | Enhanced |
| spleen | cells in white pulp | Medium | Enhanced |
| stomach 1 | glandular cells | High | Enhanced |
| stomach 2 | glandular cells | High | Enhanced |
| testis | sertoli cells | Medium | Enhanced |
| thyroid gland | glandular cells | Medium | Enhanced |
| tonsil | germinal center cells | High | Enhanced |
| tonsil | non-germinal center cells | High | Enhanced |
| tonsil | squamous epithelial cells | Medium | Enhanced |
| urinary bladder | urothelial cells | High | Enhanced |
| vagina | squamous epithelial cells | Low | Enhanced |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| autosomal systemic lupus erythematosus type 16 | MONDO:0013743 | M32 | chapter13, Diseases of the musculoskeletal system and connective tissue | OMIM:614420 | Orphanet:300345 |
| autoimmune lymphoproliferative syndrome type 3 | MONDO:0014253 | D47 | chapter2, Neoplasms | ||
| common variable immunodeficiency | MONDO:0015517 | D83 | chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | OMIMPS:607594 | Orphanet:1572 |