MultifacetedProtDB - Bologna Biocomputing Group

Summary of Q05655

Gene: PRKCD, PKCD
Protein: Protein kinase C delta type

Protein family
Protein sequence
Protein function

Catalytic activity

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EC number	EC number description
2.7.10.2	Transferases; Transferring phosphorus-containing groups; Protein-tyrosine kinases; non-specific protein-tyrosine kinase
2.7.11.13	Transferases; Transferring phosphorus-containing groups; Protein-serine/threonine kinases; protein kinase C

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Publications

Structure

GO term

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GO ontology	GO term	GO description
Biological Process	GO:0042100	B cell proliferation
Biological Process	GO:0006974	DNA damage response
Biological Process	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
Biological Process	GO:0032147	activation of protein kinase activity
Biological Process	GO:0006915	apoptotic process
Biological Process	GO:0060326	cell chemotaxis
Biological Process	GO:0007049	cell cycle
Biological Process	GO:0034644	cellular response to UV
Biological Process	GO:1904385	cellular response to angiotensin
Biological Process	GO:0070301	cellular response to hydrogen peroxide

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InterPro / Pfam

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InterPro	InterPro name
IPR000008	C2 domain
IPR000719	Protein kinase domain
IPR000961	AGC-kinase, C-terminal
IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR008271	Serine/threonine-protein kinase, active site
IPR011009	Protein kinase-like domain superfamily
IPR014376	Protein kinase C, delta/epsilon/eta/theta types
IPR017441	Protein kinase, ATP binding site
IPR017892	Protein kinase, C-terminal
IPR020454	Diacylglycerol/phorbol-ester binding

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Pfam	Pfam name
PF00069	Protein kinase domain
PF00130	Phorbol esters/diacylglycerol binding domain (C1 domain)
PF00433	Protein kinase C terminal domain

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Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

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Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Enhanced
adrenal gland	glandular cells	Medium	Enhanced
appendix	glandular cells	High	Enhanced
appendix	lymphoid tissue	High	Enhanced
bone marrow	hematopoietic cells	High	Enhanced
breast	adipocytes	Low	Enhanced
bronchus	respiratory epithelial cells	High	Enhanced
caudate	glial cells	Low	Enhanced
caudate	neuronal cells	Medium	Enhanced
cerebellum	Purkinje cells - cytoplasm/membrane	Medium	Enhanced

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Disease

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Disease name	MONDO ID	ICD10	ICD10 chapter	OMIM	Orphanet
autoimmune lymphoproliferative syndrome type 3	MONDO:0014253	D47	chapter2, Neoplasms
autosomal systemic lupus erythematosus type 16	MONDO:0013743	M32	chapter13, Diseases of the musculoskeletal system and connective tissue	OMIM:614420	Orphanet:300345
common variable immunodeficiency	MONDO:0015517	D83	chapter3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	OMIMPS:607594	Orphanet:1572

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