MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
1.17.3.-	Oxidoreductases; Acting on CH or CH2 groups; With oxygen as acceptor;
1.2.3.1	Oxidoreductases; Acting on the aldehyde or oxo group of donors; With oxygen as acceptor; aldehyde oxidase

PDB	Resolution (Å)	PDB name
4UHW	2.6	Human aldehyde oxidase
4UHX	2.7	Human aldehyde oxidase in complex with phthalazine and thioridazine
5EPG	3.39	Human aldehyde oxidase SNP S1271L
6Q6Q	3.10004	Human aldehyde oxidase SNP G1269R
7OPN	2.6	Human Aldehyde Oxidase SNP R1231H in complex with Raloxifene
7ORC	2.7	Human Aldehyde Oxidase in complex with Raloxifene

GO ontology	GO term	GO description
Biological Process	GO:0006629	lipid metabolic process
Biological Process	GO:0006805	xenobiotic metabolic process
Molecular Function	GO:0051537	2 iron, 2 sulfur cluster binding
Molecular Function	GO:0071949	FAD binding
Molecular Function	GO:0051287	NAD binding
Molecular Function	GO:0004031	aldehyde oxidase activity
Molecular Function	GO:0050660	flavin adenine dinucleotide binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0005506	iron ion binding
Molecular Function	GO:0043546	molybdopterin cofactor binding
Molecular Function	GO:0042803	protein homodimerization activity
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome

InterPro	InterPro name
IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain
IPR002346	Molybdopterin dehydrogenase, FAD-binding
IPR002888	[2Fe-2S]-binding
IPR005107	CO dehydrogenase flavoprotein, C-terminal
IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site
IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain
IPR012675	Beta-grasp domain superfamily
IPR014313	Aldehyde oxidase
IPR016166	FAD-binding domain, PCMH-type
IPR016167	FAD-binding, type PCMH, subdomain 1
IPR016169	FAD-binding, type PCMH, subdomain 2
IPR016208	Aldehyde oxidase/xanthine dehydrogenase
IPR022407	Oxidoreductase, molybdopterin binding site
IPR036010	2Fe-2S ferredoxin-like superfamily
IPR036318	FAD-binding, type PCMH-like superfamily
IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily
IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
IPR036884	[2Fe-2S]-binding domain superfamily
IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily
IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain

Pfam	Pfam name
PF00111	2Fe-2S iron-sulfur cluster binding domain
PF00941	FAD binding domain in molybdopterin dehydrogenase
PF01315	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
PF01799	[2Fe-2S] binding domain
PF02738	Molybdopterin cofactor-binding domain
PF03450	CO dehydrogenase flavoprotein C-terminal domain
PF20256	Molybdopterin cofactor-binding domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-964975	Vitamins B6 activation to pyridoxal phosphate	Leaf	R-HSA-1430728	Metabolism

Tissue	Cell type	Expression level	Reliability
adrenal gland	glandular cells	High	Enhanced
endometrium 2	glandular cells	Low	Enhanced
gallbladder	glandular cells	Low	Enhanced
kidney	proximal tubules (cell body)	Low	Enhanced
liver	hepatocytes	High	Enhanced
pancreas	exocrine glandular cells	Low	Enhanced
seminal vesicle	glandular cells	Low	Enhanced
testis	Leydig cells	High	Enhanced