MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
2H2B	1.6	Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTYL)
2H2C	2.0	Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV)
2H3M	2.9	Crystal Structure of ZO-1 PDZ1
2JWE		Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping
2KXR		ZO1 ZU5 domain MC/AA mutation
2KXS		ZO1 ZU5 domain in complex with GRINL1A peptide
2RCZ	1.7	Structure of the second PDZ domain of ZO-1
3CYY	2.4	The crystal structure of ZO-1 PDZ2 in complex with the Cx43 peptide
3LH5	2.6	Crystal Structure of the SH3-Guanylate kinase core domain of ZO-1
3SHU	2.75	Crystal structure of ZO-1 PDZ3
3SHW	2.9	Crystal structure of ZO-1 PDZ3-SH3-Guk supramodule complex with Connexin-45 peptide
3TSV	1.989	crystal structure of the third PDZ domain of the human ZO-1 MAGUK protein
3TSW	2.847	crystal structure of the PDZ3-SH3-GUK core module of Human ZO-1
3TSZ	2.502	crystal structure of PDZ3-SH3-GUK core module from human ZO-1 in complex with 12mer peptide from human JAM-A cytoplasmic tail
4OEO	1.9	High resolution crystal structure of the unliganded ZO-1 PDZ1 domain
4OEP	2.35	Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin1 C-terminal tail
4Q2Q	1.45	ZO1 PDZ3 in Complex with a Phage-Derived Peptide
4YYX	1.79	Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail

GO term

GO ontology	GO term	GO description
Biological Process	GO:0030036	actin cytoskeleton organization
Biological Process	GO:0031032	actomyosin structure organization
Biological Process	GO:0034334	adherens junction maintenance
Biological Process	GO:0098609	cell-cell adhesion
Biological Process	GO:0007043	cell-cell junction assembly
Biological Process	GO:0045216	cell-cell junction organization
Biological Process	GO:0090557	establishment of endothelial intestinal barrier
Biological Process	GO:0035633	maintenance of blood-brain barrier
Biological Process	GO:0043066	negative regulation of apoptotic process
Biological Process	GO:0051497	negative regulation of stress fiber assembly
Biological Process	GO:1905605	positive regulation of blood-brain barrier permeability
Biological Process	GO:0030335	positive regulation of cell migration
Biological Process	GO:0008284	positive regulation of cell population proliferation
Biological Process	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis
Biological Process	GO:0071896	protein localization to adherens junction
Biological Process	GO:1902396	protein localization to bicellular tight junction
Biological Process	GO:0150105	protein localization to cell-cell junction
Biological Process	GO:2000810	regulation of bicellular tight junction assembly
Biological Process	GO:1901888	regulation of cell junction assembly
Biological Process	GO:0051493	regulation of cytoskeleton organization
Molecular Function	GO:0045296	cadherin binding
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0050839	cell adhesion molecule binding
Cellular Component	GO:0005912	adherens junction
Cellular Component	GO:0043296	apical junction complex
Cellular Component	GO:0045177	apical part of cell
Cellular Component	GO:0016323	basolateral plasma membrane
Cellular Component	GO:0005923	bicellular tight junction
Cellular Component	GO:0030054	cell junction
Cellular Component	GO:0042995	cell projection
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005921	gap junction
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0002102	podosome
Cellular Component	GO:0032991	protein-containing complex
Cellular Component	GO:0070160	tight junction

InterPro / Pfam

InterPro	InterPro name
IPR000906	ZU5 domain
IPR001452	SH3 domain
IPR001478	PDZ domain
IPR005417	Tight junction protein ZO
IPR005418	Tight junction protein ZO-1
IPR008144	Guanylate kinase-like domain
IPR008145	Guanylate kinase/L-type calcium channel beta subunit
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR035597	ZO-1, SH3 domain
IPR036028	SH3-like domain superfamily
IPR036034	PDZ superfamily

Pfam	Pfam name
PF00595	PDZ domain
PF00625	Guanylate kinase
PF00791	ZU5 domain
PF07653	Variant SH3 domain

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-191650	Regulation of gap junction activity	Leaf	R-HSA-5653656	Vesicle-mediated transport
R-HSA-2028269	Signaling by Hippo	Leaf	R-HSA-162582	Signal Transduction
R-HSA-351906	Apoptotic cleavage of cell adhesion proteins	Leaf	R-HSA-5357801	Programmed Cell Death
R-HSA-8935964	RUNX1 regulates expression of components of tight junctions	Leaf	R-HSA-74160	Gene expression (Transcription)
R-HSA-9705677	SARS-CoV-2 targets PDZ proteins in cell-cell junction	Leaf	R-HSA-1643685	Disease

Subcellular location

Location	ECO term	Pubmed
Cell junction	ECO:0000269	PubMed:28169360
Cell junction, gap junction	ECO:0000269
Cell junction, tight junction	ECO:0000269	PubMed:7798316
Cell membrane	ECO:0000269	PubMed:7798316
Cell projection, podosome	ECO:0000269	PubMed:20930113

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Low	Enhanced
adrenal gland	glandular cells	Low	Enhanced
appendix	glandular cells	Low	Enhanced
breast	glandular cells	Low	Enhanced
bronchus	respiratory epithelial cells	Medium	Enhanced
cerebral cortex	endothelial cells	High	Enhanced
cervix	glandular cells	Medium	Enhanced
cervix	squamous epithelial cells	Low	Enhanced
colon	endothelial cells	Medium	Enhanced
colon	glandular cells	Medium	Enhanced
colon	peripheral nerve/ganglion	Low	Enhanced
duodenum	glandular cells	Medium	Enhanced
endometrium 1	glandular cells	Medium	Enhanced
endometrium 2	glandular cells	Medium	Enhanced
epididymis	glandular cells	Medium	Enhanced
esophagus	squamous epithelial cells	Low	Enhanced
fallopian tube	glandular cells	Medium	Enhanced
gallbladder	glandular cells	Medium	Enhanced
heart muscle	cardiomyocytes	Low	Enhanced
kidney	cells in glomeruli	Medium	Enhanced
kidney	cells in tubules	Low	Enhanced
liver	cholangiocytes	Low	Enhanced
liver	hepatocytes	Low	Enhanced
lung	alveolar cells	Low	Enhanced
nasopharynx	respiratory epithelial cells	Medium	Enhanced
oral mucosa	squamous epithelial cells	Low	Enhanced
ovary	follicle cells	Low	Enhanced
pancreas	exocrine glandular cells	Medium	Enhanced
pancreas	pancreatic endocrine cells	Low	Enhanced
parathyroid gland	glandular cells	Low	Enhanced
prostate	glandular cells	Low	Enhanced
rectum	glandular cells	Medium	Enhanced
salivary gland	glandular cells	Medium	Enhanced
seminal vesicle	glandular cells	Low	Enhanced
skeletal muscle	myocytes	Medium	Enhanced
skin 1	cells in spinous layer	Low	Enhanced
skin 1	endothelial cells	Medium	Enhanced
skin 2	cells in granular layer	Low	Enhanced
skin 2	endothelial cells	Medium	Enhanced
small intestine	glandular cells	Medium	Enhanced
smooth muscle	smooth muscle cells	Low	Enhanced
spleen	cells in red pulp	Low	Enhanced
stomach 1	glandular cells	Low	Enhanced
stomach 2	glandular cells	Medium	Enhanced
testis	sertoli cells	High	Enhanced
thyroid gland	glandular cells	Medium	Enhanced
urinary bladder	urothelial cells	Low	Enhanced
vagina	squamous epithelial cells	Low	Enhanced

Summary of Q07157

Gene: TJP1, ZO1
Protein: Tight junction protein ZO-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q07157

Gene: TJP1, ZO1 Protein: Tight junction protein ZO-1

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: TJP1, ZO1
Protein: Tight junction protein ZO-1