Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.10.2
Transferases;
Transferring phosphorus-containing groups;
Protein-tyrosine kinases;
non-specific protein-tyrosine kinase
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 1CF4 | CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX | |
| 1U46 | 2.0 | Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1 |
| 1U4D | 2.1 | Structure of the ACK1 Kinase Domain bound to Debromohymenialdisine |
| 1U54 | 2.8 | Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the CDC42-associated Tyrosine Kinase ACK1 bound to AMP-PCP |
| 3EQP | 2.3 | Crystal Structure of Ack1 with compound T95 |
| 3EQR | 2.0 | Crystal Structure of Ack1 with compound T74 |
| 4EWH | 2.5 | Co-crystal structure of ACK1 with inhibitor |
| 4HZR | 1.31 | Crystal structure of Ack1 kinase domain |
| 4HZS | 3.23 | Crystal structure of Ack1 kinase domain with C-terminal SH3 domain |
| 4ID7 | 3.0 | ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol |
| 5ZXB | 2.198 | Crystal structure of ACK1 with compound 10d |
| 6VQM | 2.87 | Crystal Structure Analysis of human ACK1 |
| 7KP6 | 1.79 | Structure of Ack1 kinase in complex with a selective inhibitor |
| 8FE9 | 3.2 | Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b |
| 8FZ3 | 2.784 | Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0006897 | endocytosis |
| Biological Process | GO:0016310 | phosphorylation |
| Biological Process | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:2000369 | regulation of clathrin-dependent endocytosis |
| Biological Process | GO:0007264 | small GTPase mediated signal transduction |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0005095 | GTPase inhibitor activity |
| Molecular Function | GO:0050699 | WW domain binding |
| Molecular Function | GO:0005154 | epidermal growth factor receptor binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| Molecular Function | GO:0004713 | protein tyrosine kinase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Cellular Component | GO:0070436 | Grb2-EGFR complex |
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0005905 | clathrin-coated pit |
| Cellular Component | GO:0030136 | clathrin-coated vesicle |
| Cellular Component | GO:0097268 | cytoophidium |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005768 | endosome |
| Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| InterPro
|
InterPro name |
|---|---|
| IPR000719 | Protein kinase domain |
| IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| IPR001452 | SH3 domain |
| IPR008266 | Tyrosine-protein kinase, active site |
| IPR011009 | Protein kinase-like domain superfamily |
| IPR015116 | Cdc42 binding domain-like |
| IPR017441 | Protein kinase, ATP binding site |
| IPR020635 | Tyrosine-protein kinase, catalytic domain |
| IPR021619 | Mig-6 domain |
| IPR030220 | Activated CDC42 kinase 1, UBA domain |
| IPR036028 | SH3-like domain superfamily |
| IPR037085 | Cdc42 binding domain-like superfamily |
| Pfam
|
Pfam name |
|---|---|
| PF07714 | Protein tyrosine and serine/threonine kinase |
| PF09027 | GTPase binding |
| PF11555 | EGFR receptor inhibitor Mig-6 |
| PF14604 | Variant SH3 domain |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cell junction, adherens junction | ECO:0000305 | |
| Cell membrane | ECO:0000269 | PubMed:20333297 |
| Cell membrane | ECO:0000269 | PubMed:20979614 |
| Cytoplasm, cytosol | ECO:0000250 | |
| Cytoplasm, perinuclear region | ECO:0000269 | PubMed:20110370 |
| Cytoplasmic vesicle membrane | PubMed:16137687 | |
| Cytoplasmic vesicle, clathrin-coated vesicle | ECO:0000269 | PubMed:16137687 |
| Cytoplasmic vesicle, clathrin-coated vesicle | ECO:0000269 | PubMed:18262180 |
| Endosome | ECO:0000250 | |
| Membrane, clathrin-coated pit | ECO:0000269 | PubMed:21169560 |
| Nucleus | ECO:0000269 | PubMed:14733946 |
| Nucleus | ECO:0000269 | PubMed:20333297 |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|---|---|---|---|---|
| infantile-onset mesial temporal lobe epilepsy with severe cognitive regression | MONDO:0018314 | G40 | chapter6, Diseases of the nervous system | Orphanet:391316 |