Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
2.7.10.2
Transferases;
Transferring phosphorus-containing groups;
Protein-tyrosine kinases;
non-specific protein-tyrosine kinase
2.7.11.1
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases;
non-specific serine/threonine protein kinase
PDB | Resolution (Å) | PDB name |
---|---|---|
1CF4 | CDC42/ACK GTPASE-BINDING DOMAIN COMPLEX | |
1U46 | 2.0 | Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1 |
1U4D | 2.1 | Structure of the ACK1 Kinase Domain bound to Debromohymenialdisine |
1U54 | 2.8 | Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the CDC42-associated Tyrosine Kinase ACK1 bound to AMP-PCP |
3EQP | 2.3 | Crystal Structure of Ack1 with compound T95 |
3EQR | 2.0 | Crystal Structure of Ack1 with compound T74 |
4EWH | 2.5 | Co-crystal structure of ACK1 with inhibitor |
4HZR | 1.31 | Crystal structure of Ack1 kinase domain |
4HZS | 3.23 | Crystal structure of Ack1 kinase domain with C-terminal SH3 domain |
4ID7 | 3.0 | ACK1 kinase in complex with the inhibitor cis-3-[8-amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]cyclobutanol |
5ZXB | 2.198 | Crystal structure of ACK1 with compound 10d |
6VQM | 2.87 | Crystal Structure Analysis of human ACK1 |
7KP6 | 1.79 | Structure of Ack1 kinase in complex with a selective inhibitor |
8FE9 | 3.2 | Crystal structure of Ack1 kinase K161Q mutant in complex with the selective inhibitor (R)-9b |
8FZ3 | 2.784 | Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0007166 | cell surface receptor signaling pathway |
Biological Process | GO:0006897 | endocytosis |
Biological Process | GO:0016310 | phosphorylation |
Biological Process | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
Biological Process | GO:0006468 | protein phosphorylation |
Biological Process | GO:2000369 | regulation of clathrin-dependent endocytosis |
Biological Process | GO:0007264 | small GTPase mediated signal transduction |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0005095 | GTPase inhibitor activity |
Molecular Function | GO:0050699 | WW domain binding |
Molecular Function | GO:0005154 | epidermal growth factor receptor binding |
Molecular Function | GO:0042802 | identical protein binding |
Molecular Function | GO:0046872 | metal ion binding |
Molecular Function | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
Molecular Function | GO:0106310 | protein serine kinase activity |
Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
Molecular Function | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
Molecular Function | GO:0004713 | protein tyrosine kinase activity |
Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
Cellular Component | GO:0070436 | Grb2-EGFR complex |
Cellular Component | GO:0005912 | adherens junction |
Cellular Component | GO:0005905 | clathrin-coated pit |
Cellular Component | GO:0030136 | clathrin-coated vesicle |
Cellular Component | GO:0097268 | cytoophidium |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0030659 | cytoplasmic vesicle membrane |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005768 | endosome |
Cellular Component | GO:0043231 | intracellular membrane-bounded organelle |
Cellular Component | GO:0016020 | membrane |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
Cellular Component | GO:0005886 | plasma membrane |
InterPro | InterPro name |
---|---|
IPR000719 | Protein kinase domain |
IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
IPR001452 | SH3 domain |
IPR008266 | Tyrosine-protein kinase, active site |
IPR011009 | Protein kinase-like domain superfamily |
IPR015116 | Cdc42 binding domain-like |
IPR017441 | Protein kinase, ATP binding site |
IPR020635 | Tyrosine-protein kinase, catalytic domain |
IPR021619 | Mig-6 domain |
IPR030220 | Activated CDC42 kinase 1, UBA domain |
IPR036028 | SH3-like domain superfamily |
IPR037085 | Cdc42 binding domain-like superfamily |
Pfam | Pfam name |
---|---|
PF07714 | Protein tyrosine and serine/threonine kinase |
PF09027 | GTPase binding |
PF11555 | EGFR receptor inhibitor Mig-6 |
PF14604 | Variant SH3 domain |
Location | ECO term | Pubmed |
---|---|---|
Cell junction, adherens junction | ECO:0000305 | |
Cell membrane | ECO:0000269 | PubMed:20333297 |
Cell membrane | ECO:0000269 | PubMed:20979614 |
Cytoplasm, cytosol | ECO:0000250 | |
Cytoplasm, perinuclear region | ECO:0000269 | PubMed:20110370 |
Cytoplasmic vesicle membrane | PubMed:16137687 | |
Cytoplasmic vesicle, clathrin-coated vesicle | ECO:0000269 | PubMed:16137687 |
Cytoplasmic vesicle, clathrin-coated vesicle | ECO:0000269 | PubMed:18262180 |
Endosome | ECO:0000250 | |
Membrane, clathrin-coated pit | ECO:0000269 | PubMed:21169560 |
Nucleus | ECO:0000269 | PubMed:14733946 |
Nucleus | ECO:0000269 | PubMed:20333297 |
Disease name | MONDO ID | ICD10 | ICD10 chapter | OMIM | Orphanet |
---|---|---|---|---|---|
infantile-onset mesial temporal lobe epilepsy with severe cognitive regression | MONDO:0018314 | G40 | chapter6, Diseases of the nervous system | Orphanet:391316 |