Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
3.6.4.13
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
RNA helicase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3LLM | 2.8 | Crystal Structure Analysis of a RNA Helicase |
| 3VYX | 2.29 | Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase (DHX9) |
| 3VYY | 2.9 | Structural insights into RISC assembly facilitated by dsRNA binding domains of human RNA helicase A (DHX9) |
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0070934 | CRD-mediated mRNA stabilization |
| Biological Process | GO:0032508 | DNA duplex unwinding |
| Biological Process | GO:0006260 | DNA replication |
| Biological Process | GO:0006353 | DNA-templated transcription termination |
| Biological Process | GO:0039695 | DNA-templated viral transcription |
| Biological Process | GO:0044806 | G-quadruplex DNA unwinding |
| Biological Process | GO:0070922 | RISC complex assembly |
| Biological Process | GO:0010501 | RNA secondary structure unwinding |
| Biological Process | GO:0000380 | alternative mRNA splicing, via spliceosome |
| Biological Process | GO:0071360 | cellular response to exogenous dsRNA |
| Biological Process | GO:0071356 | cellular response to tumor necrosis factor |
| Biological Process | GO:0098795 | global gene silencing by mRNA cleavage |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:1900152 | negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| Biological Process | GO:0001649 | osteoblast differentiation |
| Biological Process | GO:0045739 | positive regulation of DNA repair |
| Biological Process | GO:0045740 | positive regulation of DNA replication |
| Biological Process | GO:2000373 | positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity |
| Biological Process | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| Biological Process | GO:0046833 | positive regulation of RNA export from nucleus |
| Biological Process | GO:2000767 | positive regulation of cytoplasmic translation |
| Biological Process | GO:0048146 | positive regulation of fibroblast proliferation |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0045089 | positive regulation of innate immune response |
| Biological Process | GO:0032727 | positive regulation of interferon-alpha production |
| Biological Process | GO:0032728 | positive regulation of interferon-beta production |
| Biological Process | GO:0032741 | positive regulation of interleukin-18 production |
| Biological Process | GO:0032755 | positive regulation of interleukin-6 production |
| Biological Process | GO:2000637 | positive regulation of miRNA-mediated gene silencing |
| Biological Process | GO:1905698 | positive regulation of polysome binding |
| Biological Process | GO:0060760 | positive regulation of response to cytokine stimulus |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0032760 | positive regulation of tumor necrosis factor production |
| Biological Process | GO:0050434 | positive regulation of viral transcription |
| Biological Process | GO:1904973 | positive regulation of viral translation |
| Biological Process | GO:1903608 | protein localization to cytoplasmic stress granule |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0070269 | pyroptosis |
| Biological Process | GO:2000765 | regulation of cytoplasmic translation |
| Biological Process | GO:0050691 | regulation of defense response to virus by host |
| Biological Process | GO:0050684 | regulation of mRNA processing |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0048511 | rhythmic process |
| Molecular Function | GO:0043138 | 3'-5' DNA helicase activity |
| Molecular Function | GO:0033679 | 3'-5' DNA/RNA helicase activity |
| Molecular Function | GO:0034458 | 3'-5' RNA helicase activity |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003678 | DNA helicase activity |
| Molecular Function | GO:0003688 | DNA replication origin binding |
| Molecular Function | GO:1905172 | RISC complex binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003724 | RNA helicase activity |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0000993 | RNA polymerase II complex binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0070063 | RNA polymerase binding |
| Molecular Function | GO:0035613 | RNA stem-loop binding |
| Molecular Function | GO:0031490 | chromatin DNA binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0003725 | double-stranded RNA binding |
| Molecular Function | GO:0061676 | importin-alpha family protein binding |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0047429 | nucleoside triphosphate diphosphatase activity |
| Molecular Function | GO:1905538 | polysome binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Molecular Function | GO:0001069 | regulatory region RNA binding |
| Molecular Function | GO:0017111 | ribonucleoside triphosphate phosphatase activity |
| Molecular Function | GO:1990825 | sequence-specific mRNA binding |
| Molecular Function | GO:0035197 | siRNA binding |
| Molecular Function | GO:1990518 | single-stranded 3'-5' DNA helicase activity |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0003727 | single-stranded RNA binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Molecular Function | GO:0003712 | transcription coregulator activity |
| Molecular Function | GO:0045142 | triplex DNA binding |
| Cellular Component | GO:0070937 | CRD-mediated mRNA stability complex |
| Cellular Component | GO:0016442 | RISC complex |
| Cellular Component | GO:0070578 | RISC-loading complex |
| Cellular Component | GO:0015629 | actin cytoskeleton |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0097165 | nuclear stress granule |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005726 | perichromatin fibrils |
| Cellular Component | GO:0042788 | polysomal ribosome |
| Cellular Component | GO:0005844 | polysome |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| InterPro
|
InterPro name |
|---|---|
| IPR001650 | Helicase, C-terminal |
| IPR002464 | DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site |
| IPR007502 | Helicase-associated domain |
| IPR011545 | DEAD/DEAH box helicase domain |
| IPR011709 | DEAD-box helicase, OB fold |
| IPR014001 | Helicase superfamily 1/2, ATP-binding domain |
| IPR014720 | Double-stranded RNA-binding domain |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR044445 | DHX9, first double-stranded RNA binding domain |
| IPR044446 | DHX9, second double-stranded RNA binding domain |
| IPR044447 | DHX9, DEXH-box helicase domain |
| Pfam
|
Pfam name |
|---|---|
| PF00035 | Double-stranded RNA binding motif |
| PF00270 | DEAD/DEAH box helicase |
| PF00271 | Helicase conserved C-terminal domain |
| PF04408 | Helicase associated domain (HA2) |
| PF07717 | Oligonucleotide/oligosaccharide-binding (OB)-fold |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 | Leaf | R-HSA-168256 | Immune System |
| R-HSA-3134963 | DEx/H-box helicases activate type I IFN and inflammatory cytokines production | Leaf | R-HSA-168256 | Immune System |
| R-HSA-72163 | mRNA Splicing - Major Pathway | Leaf | R-HSA-8953854 | Metabolism of RNA |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm | ECO:0000269 | PubMed:10198287 |
| Cytoplasm | ECO:0000269 | PubMed:10207077 |
| Cytoplasm | ECO:0000269 | PubMed:16375861 |
| Cytoplasm | ECO:0000269 | PubMed:17289661 |
| Cytoplasm | ECO:0000269 | PubMed:19029303 |
| Cytoplasm | ECO:0000269 | PubMed:20696886 |
| Cytoplasm | ECO:0000269 | PubMed:8690889 |
| Cytoplasm | ECO:0000269 | PubMed:9162007 |
| Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | ECO:0000269 | PubMed:14654843 |
| Cytoplasm, cytoskeleton, microtubule organizing center, centrosome | ECO:0000269 | PubMed:17498979 |
| Nucleus | ECO:0000269 | PubMed:10198287 |
| Nucleus | ECO:0000269 | PubMed:10207077 |
| Nucleus | ECO:0000269 | PubMed:11687588 |
| Nucleus | ECO:0000269 | PubMed:16375861 |
| Nucleus | ECO:0000269 | PubMed:17303075 |
| Nucleus | ECO:0000269 | PubMed:9162007 |
| Nucleus, nucleolus | ECO:0000269 | PubMed:12429849 |
| Nucleus, nucleoplasm | ECO:0000269 | PubMed:28221134 |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Supported |
| adrenal gland | glandular cells | High | Supported |
| appendix | glandular cells | High | Supported |
| appendix | lymphoid tissue | Medium | Supported |
| bone marrow | hematopoietic cells | High | Supported |
| breast | glandular cells | High | Supported |
| breast | myoepithelial cells | High | Supported |
| bronchus | respiratory epithelial cells | Medium | Supported |
| caudate | glial cells | High | Supported |
| caudate | neuronal cells | High | Supported |
| cerebellum | Purkinje cells | High | Supported |
| cerebellum | cells in granular layer | High | Supported |
| cerebellum | cells in molecular layer | High | Supported |
| cerebral cortex | endothelial cells | Low | Supported |
| cerebral cortex | glial cells | High | Supported |
| cerebral cortex | neuronal cells | High | Supported |
| cervix | glandular cells | High | Supported |
| cervix | squamous epithelial cells | High | Supported |
| colon | endothelial cells | High | Supported |
| colon | glandular cells | High | Supported |
| colon | peripheral nerve/ganglion | High | Supported |
| duodenum | glandular cells | High | Supported |
| endometrium 1 | cells in endometrial stroma | Medium | Supported |
| endometrium 1 | glandular cells | Medium | Supported |
| endometrium 2 | cells in endometrial stroma | Medium | Supported |
| endometrium 2 | glandular cells | Medium | Supported |
| epididymis | glandular cells | High | Supported |
| esophagus | squamous epithelial cells | High | Supported |
| fallopian tube | glandular cells | High | Supported |
| gallbladder | glandular cells | High | Supported |
| heart muscle | cardiomyocytes | Medium | Supported |
| hippocampus | glial cells | Medium | Supported |
| hippocampus | neuronal cells | High | Supported |
| kidney | cells in glomeruli | High | Supported |
| kidney | cells in tubules | High | Supported |
| liver | cholangiocytes | Low | Supported |
| liver | hepatocytes | Medium | Supported |
| lung | alveolar cells type I | High | Supported |
| lung | alveolar cells type II | High | Supported |
| lung | endothelial cells | Low | Supported |
| lung | macrophages | Medium | Supported |
| lymph node | germinal center cells | Medium | Supported |
| lymph node | non-germinal center cells | Medium | Supported |
| nasopharynx | respiratory epithelial cells | High | Supported |
| oral mucosa | squamous epithelial cells | Medium | Supported |
| ovary | follicle cells | High | Supported |
| ovary | ovarian stroma cells | Medium | Supported |
| pancreas | exocrine glandular cells | High | Supported |
| pancreas | pancreatic endocrine cells | High | Supported |
| parathyroid gland | glandular cells | High | Supported |
| placenta | cytotrophoblasts | High | Supported |
| placenta | endothelial cells | High | Supported |
| placenta | hofbauer cells | High | Supported |
| placenta | syncytiotrophoblasts - cell body | High | Supported |
| prostate | glandular cells | Medium | Supported |
| rectum | glandular cells | High | Supported |
| salivary gland | glandular cells | High | Supported |
| seminal vesicle | glandular cells | Medium | Supported |
| skeletal muscle | myocytes | High | Supported |
| skin 1 | Langerhans | Medium | Supported |
| skin 1 | fibroblasts | Medium | Supported |
| skin 1 | keratinocytes | Medium | Supported |
| skin 1 | melanocytes | Medium | Supported |
| skin 2 | epidermal cells | High | Supported |
| small intestine | glandular cells | High | Supported |
| smooth muscle | smooth muscle cells | Medium | Supported |
| soft tissue 1 | chondrocytes | Medium | Supported |
| soft tissue 1 | fibroblasts | Medium | Supported |
| soft tissue 1 | peripheral nerve | Medium | Supported |
| soft tissue 2 | fibroblasts | Medium | Supported |
| soft tissue 2 | peripheral nerve | Medium | Supported |
| spleen | cells in red pulp | Medium | Supported |
| spleen | cells in white pulp | Medium | Supported |
| stomach 1 | glandular cells | High | Supported |
| stomach 2 | glandular cells | High | Supported |
| testis | Leydig cells | High | Supported |
| testis | pachytene spermatocytes | High | Supported |
| testis | preleptotene spermatocytes | Low | Supported |
| testis | round or early spermatids | High | Supported |
| testis | sertoli cells | Medium | Supported |
| testis | spermatogonia cells | High | Supported |
| thyroid gland | glandular cells | High | Supported |
| tonsil | germinal center cells | Medium | Supported |
| tonsil | non-germinal center cells | Medium | Supported |
| tonsil | squamous epithelial cells | Medium | Supported |
| urinary bladder | urothelial cells | High | Supported |
| vagina | squamous epithelial cells | High | Supported |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|