Protein family
Protein sequence
Protein function
Publications
Catalytic activity
EC number
EC number description
2.4.3.2
Transferases;
Glycosyltransferases;
Sialyltransferases;
β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminide α-2,3-sialyltransferase
2.4.3.4
Transferases;
Glycosyltransferases;
Sialyltransferases;
β-galactoside α-2,3-sialyltransferase
| PDB | Resolution (Å) | PDB name |
|---|
GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0006054 | N-acetylneuraminate metabolic process |
| Biological Process | GO:0016266 | O-glycan processing |
| Biological Process | GO:0010706 | ganglioside biosynthetic process via lactosylceramide |
| Biological Process | GO:0018146 | keratan sulfate biosynthetic process |
| Biological Process | GO:0002319 | memory B cell differentiation |
| Biological Process | GO:1905403 | negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process |
| Biological Process | GO:0006487 | protein N-linked glycosylation |
| Biological Process | GO:0006486 | protein glycosylation |
| Biological Process | GO:0036211 | protein modification process |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:1990743 | protein sialylation |
| Biological Process | GO:0097503 | sialylation |
| Biological Process | GO:0019082 | viral protein processing |
| Molecular Function | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity |
| Molecular Function | GO:0047288 | monosialoganglioside sialyltransferase activity |
| Molecular Function | GO:0008373 | sialyltransferase activity |
| Cellular Component | GO:1990675 | Golgi medial cisterna membrane |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:1990676 | Golgi trans cisterna membrane |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0032588 | trans-Golgi network membrane |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-2022854 | Keratan sulfate biosynthesis | Leaf | R-HSA-1430728 | Metabolism |
| R-HSA-4085001 | Sialic acid metabolism | Leaf | R-HSA-392499 | Metabolism of proteins |
| R-HSA-9683673 | Maturation of protein 3a | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9694548 | Maturation of spike protein | Leaf | R-HSA-1643685 | Disease |
| R-HSA-9694719 | Maturation of protein 3a | Leaf | R-HSA-1643685 | Disease |
| R-HSA-977068 | Termination of O-glycan biosynthesis | Leaf | R-HSA-392499 | Metabolism of proteins |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Golgi apparatus, Golgi stack membrane | ECO:0000269 | PubMed:9182658 |
| Golgi apparatus, trans-Golgi network membrane | ECO:0000269 | PubMed:9182658 |
| Secreted |
| HPO ID
|
HPO name |
|---|
| Tissue
|
Cell type
|
Expression level | Reliability |
|---|---|---|---|
| adipose tissue | adipocytes | Medium | Approved |
| adrenal gland | glandular cells | High | Approved |
| appendix | glandular cells | Medium | Approved |
| bone marrow | hematopoietic cells | Low | Approved |
| breast | glandular cells | Medium | Approved |
| breast | myoepithelial cells | Medium | Approved |
| bronchus | respiratory epithelial cells | Low | Approved |
| caudate | neuronal cells | Low | Approved |
| cerebellum | Purkinje cells | Low | Approved |
| cerebellum | cells in granular layer | Low | Approved |
| cerebral cortex | endothelial cells | Low | Approved |
| cerebral cortex | neuropil | Low | Approved |
| cervix | glandular cells | Low | Approved |
| colon | glandular cells | High | Approved |
| duodenum | glandular cells | High | Approved |
| endometrium 1 | cells in endometrial stroma | Low | Approved |
| endometrium 1 | glandular cells | Medium | Approved |
| endometrium 2 | glandular cells | Medium | Approved |
| epididymis | glandular cells | High | Approved |
| esophagus | squamous epithelial cells | Medium | Approved |
| fallopian tube | glandular cells | Medium | Approved |
| gallbladder | glandular cells | High | Approved |
| heart muscle | cardiomyocytes | Medium | Approved |
| hippocampus | neuronal cells | Low | Approved |
| kidney | cells in glomeruli | Medium | Approved |
| kidney | cells in tubules | High | Approved |
| liver | cholangiocytes | Medium | Approved |
| liver | hepatocytes | High | Approved |
| lung | alveolar cells | Low | Approved |
| lung | macrophages | Medium | Approved |
| lymph node | germinal center cells | Medium | Approved |
| lymph node | non-germinal center cells | Medium | Approved |
| nasopharynx | respiratory epithelial cells | Medium | Approved |
| oral mucosa | squamous epithelial cells | Medium | Approved |
| ovary | ovarian stroma cells | Low | Approved |
| pancreas | exocrine glandular cells | Medium | Approved |
| pancreas | pancreatic endocrine cells | Low | Approved |
| parathyroid gland | glandular cells | Medium | Approved |
| placenta | decidual cells | Medium | Approved |
| placenta | trophoblastic cells | High | Approved |
| prostate | glandular cells | Low | Approved |
| rectum | glandular cells | Medium | Approved |
| salivary gland | glandular cells | Medium | Approved |
| seminal vesicle | glandular cells | High | Approved |
| skeletal muscle | myocytes | Medium | Approved |
| skin 1 | Langerhans | Medium | Approved |
| skin 1 | fibroblasts | Low | Approved |
| skin 1 | melanocytes | Low | Approved |
| skin 2 | epidermal cells | Low | Approved |
| small intestine | glandular cells | High | Approved |
| smooth muscle | smooth muscle cells | Low | Approved |
| soft tissue 1 | chondrocytes | Medium | Approved |
| soft tissue 1 | fibroblasts | Medium | Approved |
| soft tissue 1 | peripheral nerve | Low | Approved |
| soft tissue 2 | fibroblasts | Medium | Approved |
| soft tissue 2 | peripheral nerve | Medium | Approved |
| spleen | cells in white pulp | Low | Approved |
| stomach 1 | glandular cells | High | Approved |
| stomach 2 | glandular cells | Low | Approved |
| testis | Leydig cells | Medium | Approved |
| testis | spermatogonia cells | Medium | Approved |
| thyroid gland | glandular cells | Medium | Approved |
| tonsil | germinal center cells | Medium | Approved |
| tonsil | non-germinal center cells | Medium | Approved |
| tonsil | squamous epithelial cells | Medium | Approved |
| urinary bladder | urothelial cells | Medium | Approved |
| vagina | squamous epithelial cells | Low | Approved |
| Disease name | MONDO ID
|
ICD10
|
ICD10 chapter
|
OMIM
|
Orphanet
|
|---|