MultifacetedProtDB - Bologna Biocomputing Group

Structure

PDB	Resolution (Å)	PDB name
4Z1F	2.703	Crystal structure of human Trap1 with PU-H71
4Z1G	3.1	Crystal structure of human Trap1 with BIIB-021
4Z1H	2.9	Crystal structure of human Trap1 with SMTIN-P01
4Z1I	3.3	Crystal structure of human Trap1 with AMPPNP
5F3K	1.82	X-Ray Crystallographic Structure of hTrap1 N-terminal Domain-apo
5F5R	1.85	TRAP1N-ADPNP
5HPH	2.429	Structure of TRAP1 fragment
5Y3N	2.4	Structure of TRAP1 complexed with DN401
5Y3O	2.7	Structure of TRAP1 complexed with DN320
6XG6	3.2	Full-length human mitochondrial Hsp90 (TRAP1) with ADP-BeF3
7C04	1.7	Crystal structure of human Trap1 with DN203492
7C05	2.59	Crystal structure of human Trap1 with DN203495
7C7B	1.5	Crystal structure of human TRAP1 with SJT009
7C7C	3.0	Crystal structure of human TRAP1 with SJT104
7KCK	3.26	Full-length human mitochondrial Hsp90 (TRAP1) with AMP-PNP
7KCL	3.14	Full-length human mitochondrial Hsp90 (TRAP1) in complex with SdhB in the presence of AMP-PNP
7KCM	3.43	Full-length human mitochondrial Hsp90 (TRAP1) in complex with SdhB in the presence of AMP-PNP
7KLU	3.5	Tetrameric human mitochondrial Hsp90 (TRAP1) in the presence of AMP-PNP
7KLV	3.1	Full-length human mitochondrial Hsp90 (TRAP1) SpyCatcher/SpyTag-SdhB heterodimer in the presence of AMP-PNP

GO term

GO ontology	GO term	GO description
Biological Process	GO:0061077	chaperone-mediated protein folding
Biological Process	GO:1901856	negative regulation of cellular respiration
Biological Process	GO:1903751	negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
Biological Process	GO:1903427	negative regulation of reactive oxygen species biosynthetic process
Biological Process	GO:0006457	protein folding
Biological Process	GO:0009386	translational attenuation
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0016887	ATP hydrolysis activity
Molecular Function	GO:0140662	ATP-dependent protein folding chaperone
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0019901	protein kinase binding
Molecular Function	GO:0005164	tumor necrosis factor receptor binding
Molecular Function	GO:0051082	unfolded protein binding
Cellular Component	GO:0071944	cell periphery
Cellular Component	GO:0016020	membrane
Cellular Component	GO:0005743	mitochondrial inner membrane
Cellular Component	GO:0005758	mitochondrial intermembrane space
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005654	nucleoplasm

InterPro / Pfam

InterPro	InterPro name
IPR001404	Heat shock protein Hsp90 family
IPR003594	Histidine kinase/HSP90-like ATPase
IPR020568	Ribosomal protein S5 domain 2-type fold
IPR020575	Heat shock protein Hsp90, N-terminal
IPR036890	Histidine kinase/HSP90-like ATPase superfamily
IPR037196	HSP90, C-terminal domain

Pfam	Pfam name
PF00183	Hsp90 protein
PF13589	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Reactome

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-611105	Respiratory electron transport	Internal node	R-HSA-1430728	Metabolism

Subcellular location

Location	ECO term	Pubmed
Mitochondrion	ECO:0000269	PubMed:23564345
Mitochondrion inner membrane	ECO:0000269	PubMed:23564345
Mitochondrion matrix	ECO:0000269	PubMed:23564345

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Tissue	Cell type	Expression level	Reliability
adipose tissue	adipocytes	Medium	Enhanced
adrenal gland	glandular cells	High	Enhanced
appendix	glandular cells	High	Enhanced
bone marrow	hematopoietic cells	High	Enhanced
breast	adipocytes	High	Enhanced
breast	glandular cells	High	Enhanced
breast	myoepithelial cells	High	Enhanced
bronchus	respiratory epithelial cells	High	Enhanced
caudate	glial cells	High	Enhanced
caudate	neuronal cells	High	Enhanced
cerebellum	Purkinje cells	High	Enhanced
cerebellum	cells in granular layer	High	Enhanced
cerebellum	cells in molecular layer	High	Enhanced
cerebral cortex	endothelial cells	High	Enhanced
cerebral cortex	glial cells	High	Enhanced
cerebral cortex	neuronal cells	High	Enhanced
cerebral cortex	neuropil	High	Enhanced
cervix	glandular cells	High	Enhanced
cervix	squamous epithelial cells	High	Enhanced
colon	endothelial cells	Medium	Enhanced
colon	glandular cells	High	Enhanced
colon	peripheral nerve/ganglion	Medium	Enhanced
duodenum	glandular cells	High	Enhanced
endometrium 1	cells in endometrial stroma	High	Enhanced
endometrium 1	glandular cells	High	Enhanced
endometrium 2	cells in endometrial stroma	High	Enhanced
endometrium 2	glandular cells	High	Enhanced
epididymis	glandular cells	High	Enhanced
esophagus	squamous epithelial cells	High	Enhanced
fallopian tube	glandular cells	High	Enhanced
gallbladder	glandular cells	High	Enhanced
heart muscle	cardiomyocytes	High	Enhanced
hippocampus	glial cells	High	Enhanced
hippocampus	neuronal cells	High	Enhanced
kidney	cells in glomeruli	Medium	Enhanced
kidney	cells in tubules	High	Enhanced
liver	cholangiocytes	High	Enhanced
liver	hepatocytes	High	Enhanced
lung	alveolar cells type I	High	Enhanced
lung	alveolar cells type II	High	Enhanced
lung	endothelial cells	High	Enhanced
lung	macrophages	High	Enhanced
nasopharynx	respiratory epithelial cells	High	Enhanced
oral mucosa	squamous epithelial cells	High	Enhanced
ovary	follicle cells	High	Enhanced
ovary	ovarian stroma cells	High	Enhanced
pancreas	exocrine glandular cells	High	Enhanced
pancreas	pancreatic endocrine cells	High	Enhanced
parathyroid gland	glandular cells	High	Enhanced
placenta	decidual cells	High	Enhanced
placenta	trophoblastic cells	High	Enhanced
prostate	glandular cells	High	Enhanced
rectum	glandular cells	High	Enhanced
salivary gland	glandular cells	High	Enhanced
seminal vesicle	glandular cells	High	Enhanced
skeletal muscle	myocytes	Medium	Enhanced
skin 1	cells in basal layer	Medium	Enhanced
skin 1	cells in granular layer	Medium	Enhanced
skin 1	cells in spinous layer	Medium	Enhanced
skin 1	endothelial cells	High	Enhanced
skin 1	fibrohistiocytic cells	High	Enhanced
skin 1	langerhans cells	Medium	Enhanced
skin 1	lymphocytes	High	Enhanced
skin 1	melanocytes	High	Enhanced
skin 1	vascular mural cells	Medium	Enhanced
skin 2	cells in basal layer	High	Enhanced
skin 2	cells in granular layer	Medium	Enhanced
skin 2	cells in spinous layer	Medium	Enhanced
skin 2	endothelial cells	High	Enhanced
skin 2	fibrohistiocytic cells	High	Enhanced
skin 2	langerhans cells	Medium	Enhanced
skin 2	lymphocytes	High	Enhanced
skin 2	melanocytes	High	Enhanced
small intestine	glandular cells	High	Enhanced
smooth muscle	smooth muscle cells	Medium	Enhanced
soft tissue 1	chondrocytes	Medium	Enhanced
soft tissue 1	fibroblasts	Medium	Enhanced
soft tissue 1	peripheral nerve	Medium	Enhanced
soft tissue 2	fibroblasts	Medium	Enhanced
soft tissue 2	peripheral nerve	Medium	Enhanced
spleen	cells in red pulp	High	Enhanced
spleen	cells in white pulp	High	Enhanced
stomach 1	glandular cells	High	Enhanced
stomach 2	glandular cells	High	Enhanced
testis	Leydig cells	High	Enhanced
testis	pachytene spermatocytes	High	Enhanced
testis	peritubular cells	Medium	Enhanced
testis	preleptotene spermatocytes	High	Enhanced
testis	round or early spermatids	High	Enhanced
testis	sertoli cells	High	Enhanced
testis	spermatogonia cells	High	Enhanced
thyroid gland	glandular cells	High	Enhanced
tonsil	germinal center cells	High	Enhanced
tonsil	non-germinal center cells	High	Enhanced
tonsil	squamous epithelial cells	High	Enhanced
urinary bladder	urothelial cells	High	Enhanced
vagina	squamous epithelial cells	High	Enhanced

Summary of Q12931

Gene: TRAP1, HSP75
Protein: Heat shock protein 75 kDa, mitochondrial

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Summary of Q12931

Gene: TRAP1, HSP75 Protein: Heat shock protein 75 kDa, mitochondrial

Structure

GO term

InterPro / Pfam

Reactome

Subcellular location

Interactor | Variant | Drug

Phenotype

Tissue and cell type

Disease

Gene: TRAP1, HSP75
Protein: Heat shock protein 75 kDa, mitochondrial