Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.6.4.12
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
DNA helicase.
3.6.4.13
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
RNA helicase
PDB | Resolution (Å) | PDB name |
---|---|---|
3Q90 | 1.7 | Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1 |
4FCJ | 1.62 | Crystal structure of the NTF2-like domain of human G3BP1 |
4FCM | 2.69 | Crystal structure of the NTF2-like domain of human G3BP1 in complex with a peptide |
4IIA | 3.3 | Low resolution crystal structure of the NTF2-like domain of human G3BP1 |
5FW5 | 1.92 | Crystal structure of human G3BP1 in complex with Semliki Forest Virus nsP3-25 comprising two FGDF motives |
6TA7 | 1.93 | CRYSTAL STRUCTURE OF HUMAN G3BP1-NTF2 IN COMPLEX WITH HUMAN CAPRIN1-DERIVED SOLOMON MOTIF |
7S17 | 2.36 | Crystal structure of human G3BP1-NTF2 with three mutations- F15W, F33W, and F124W |
7SUO | 2.35 | Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein |
7XHF | 2.68 | Crystal structure of the NTF2L domain of human G3BP1 in complex with the USP10 derived peptide |
7XHG | 2.46 | Crystal structure of the NTF2L domain of human G3BP1 in complex with the Caprin-1 derived peptide |
GO ontology | GO term | GO description |
---|---|---|
Biological Process | GO:0007265 | Ras protein signal transduction |
Biological Process | GO:0051607 | defense response to virus |
Biological Process | GO:0045087 | innate immune response |
Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
Biological Process | GO:0062029 | positive regulation of stress granule assembly |
Biological Process | GO:0032481 | positive regulation of type I interferon production |
Biological Process | GO:0034063 | stress granule assembly |
Molecular Function | GO:0005524 | ATP binding |
Molecular Function | GO:0016887 | ATP hydrolysis activity |
Molecular Function | GO:0003677 | DNA binding |
Molecular Function | GO:0003678 | DNA helicase activity |
Molecular Function | GO:0033677 | DNA/RNA helicase activity |
Molecular Function | GO:0003723 | RNA binding |
Molecular Function | GO:0003724 | RNA helicase activity |
Molecular Function | GO:0004519 | endonuclease activity |
Molecular Function | GO:0003729 | mRNA binding |
Molecular Function | GO:0140693 | molecular condensate scaffold activity |
Molecular Function | GO:0043024 | ribosomal small subunit binding |
Cellular Component | GO:0005737 | cytoplasm |
Cellular Component | GO:0010494 | cytoplasmic stress granule |
Cellular Component | GO:0005829 | cytosol |
Cellular Component | GO:0005925 | focal adhesion |
Cellular Component | GO:0005634 | nucleus |
Cellular Component | GO:0043204 | perikaryon |
Cellular Component | GO:1990904 | ribonucleoprotein complex |
InterPro | InterPro name |
---|---|
IPR000504 | RNA recognition motif domain |
IPR002075 | Nuclear transport factor 2 domain |
IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
IPR018222 | Nuclear transport factor 2, eukaryote |
IPR032710 | NTF2-like domain superfamily |
IPR034374 | G3BP1, RNA recognition motif |
IPR035979 | RNA-binding domain superfamily |
IPR039539 | Ras GTPase-activating protein-binding protein |
Pfam | Pfam name |
---|---|
PF00076 | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
PF02136 | Nuclear transport factor 2 (NTF2) domain |
Reactome | Reactome Name | Node type | Reactome Root | Reactome Root Name |
---|---|---|---|---|
R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | Leaf | R-HSA-1643685 | Disease |
Location | ECO term | Pubmed |
---|---|---|
Cytoplasm, Stress granule | ECO:0000269 | PubMed:12642610 |
Cytoplasm, Stress granule | ECO:0000269 | PubMed:17210633 |
Cytoplasm, Stress granule | ECO:0000269 | PubMed:20180778 |
Cytoplasm, Stress granule | ECO:0000269 | PubMed:23953116 |
Cytoplasm, Stress granule | ECO:0000269 | PubMed:30404792 |
Cytoplasm, cytosol | ECO:0000269 | PubMed:20180778 |
Cytoplasm, cytosol | ECO:0000269 | PubMed:30510222 |
Nucleus | ECO:0000269 | PubMed:11604510 |
Perikaryon | ECO:0000250 |