Protein family
Protein sequence
Protein function
Catalytic activity
EC number
EC number description
3.6.4.12
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
DNA helicase.
3.6.4.13
Hydrolases;
Acting on acid anhydrides;
Acting on acid anhydrides to facilitate cellular and subcellular movement;
RNA helicase
| PDB | Resolution (Å) | PDB name |
|---|---|---|
| 3Q90 | 1.7 | Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1 |
| 4FCJ | 1.62 | Crystal structure of the NTF2-like domain of human G3BP1 |
| 4FCM | 2.69 | Crystal structure of the NTF2-like domain of human G3BP1 in complex with a peptide |
| 4IIA | 3.3 | Low resolution crystal structure of the NTF2-like domain of human G3BP1 |
| 5FW5 | 1.92 | Crystal structure of human G3BP1 in complex with Semliki Forest Virus nsP3-25 comprising two FGDF motives |
| 6TA7 | 1.93 | CRYSTAL STRUCTURE OF HUMAN G3BP1-NTF2 IN COMPLEX WITH HUMAN CAPRIN1-DERIVED SOLOMON MOTIF |
| 7S17 | 2.36 | Crystal structure of human G3BP1-NTF2 with three mutations- F15W, F33W, and F124W |
| 7SUO | 2.35 | Crystal Structure of the G3BP1 NTF2-like domain bound to the IDR1 of SARS-CoV-2 nucleocapsid protein |
| 7XHF | 2.68 | Crystal structure of the NTF2L domain of human G3BP1 in complex with the USP10 derived peptide |
| 7XHG | 2.46 | Crystal structure of the NTF2L domain of human G3BP1 in complex with the Caprin-1 derived peptide |
| GO ontology
|
GO term | GO description |
|---|---|---|
| Biological Process | GO:0007265 | Ras protein signal transduction |
| Biological Process | GO:0051607 | defense response to virus |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0062029 | positive regulation of stress granule assembly |
| Biological Process | GO:0032481 | positive regulation of type I interferon production |
| Biological Process | GO:0034063 | stress granule assembly |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003678 | DNA helicase activity |
| Molecular Function | GO:0033677 | DNA/RNA helicase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0003724 | RNA helicase activity |
| Molecular Function | GO:0004519 | endonuclease activity |
| Molecular Function | GO:0003729 | mRNA binding |
| Molecular Function | GO:0140693 | molecular condensate scaffold activity |
| Molecular Function | GO:0043024 | ribosomal small subunit binding |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0010494 | cytoplasmic stress granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| InterPro
|
InterPro name |
|---|---|
| IPR000504 | RNA recognition motif domain |
| IPR002075 | Nuclear transport factor 2 domain |
| IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| IPR018222 | Nuclear transport factor 2, eukaryote |
| IPR032710 | NTF2-like domain superfamily |
| IPR034374 | G3BP1, RNA recognition motif |
| IPR035979 | RNA-binding domain superfamily |
| IPR039539 | Ras GTPase-activating protein-binding protein |
| Pfam
|
Pfam name |
|---|---|
| PF00076 | RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) |
| PF02136 | Nuclear transport factor 2 (NTF2) domain |
| Reactome
|
Reactome Name | Node type
|
Reactome Root | Reactome Root Name |
|---|---|---|---|---|
| R-HSA-9705671 | SARS-CoV-2 activates/modulates innate and adaptive immune responses | Leaf | R-HSA-1643685 | Disease |
| Location
|
ECO term
|
Pubmed |
|---|---|---|
| Cytoplasm, Stress granule | ECO:0000269 | PubMed:12642610 |
| Cytoplasm, Stress granule | ECO:0000269 | PubMed:17210633 |
| Cytoplasm, Stress granule | ECO:0000269 | PubMed:20180778 |
| Cytoplasm, Stress granule | ECO:0000269 | PubMed:23953116 |
| Cytoplasm, Stress granule | ECO:0000269 | PubMed:30404792 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:20180778 |
| Cytoplasm, cytosol | ECO:0000269 | PubMed:30510222 |
| Nucleus | ECO:0000269 | PubMed:11604510 |
| Perikaryon | ECO:0000250 |