MultifacetedProtDB - Bologna Biocomputing Group

EC number	EC number description
2.7.1.134	Transferases; Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor; inositol-tetrakisphosphate 1-kinase
2.7.1.159	Transferases; Transferring phosphorus-containing groups; Phosphotransferases with an alcohol group as acceptor; inositol-1,3,4-trisphosphate 5/6-kinase

PDB	Resolution (Å)	PDB name
2ODT	2.01	Structure of human Inositol 1,3,4-trisphosphate 5/6-kinase
2Q7D	1.6	Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-kinase (ITPK1) in complex with AMPPNP and Mn2+
2QB5	1.8	Crystal Structure of Human Inositol 1,3,4-Trisphosphate 5/6-Kinase (ITPK1) in Complex with ADP and Mn2+

GO ontology	GO term	GO description
Biological Process	GO:0007596	blood coagulation
Biological Process	GO:0032957	inositol trisphosphate metabolic process
Biological Process	GO:0070266	necroptotic process
Biological Process	GO:0021915	neural tube development
Biological Process	GO:0016310	phosphorylation
Biological Process	GO:0007165	signal transduction
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0003824	catalytic activity
Molecular Function	GO:0016787	hydrolase activity
Molecular Function	GO:0047325	inositol tetrakisphosphate 1-kinase activity
Molecular Function	GO:0000825	inositol tetrakisphosphate 6-kinase activity
Molecular Function	GO:0052726	inositol-1,3,4-trisphosphate 5-kinase activity
Molecular Function	GO:0052725	inositol-1,3,4-trisphosphate 6-kinase activity
Molecular Function	GO:0016853	isomerase activity
Molecular Function	GO:0000287	magnesium ion binding
Cellular Component	GO:0016324	apical plasma membrane
Cellular Component	GO:0005829	cytosol

InterPro	InterPro name
IPR008656	Inositol-tetrakisphosphate 1-kinase
IPR011761	ATP-grasp fold
IPR040464	Inositol 1,3,4-trisphosphate 5/6-kinase, ATP-grasp domain
IPR041429	Inositol-tetrakisphosphate 1-kinase, N-terminal

Pfam	Pfam name
PF05770	Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain
PF17927	Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain

Reactome	Reactome Name	Node type	Reactome Root	Reactome Root Name
R-HSA-1855167	Synthesis of pyrophosphates in the cytosol	Leaf	R-HSA-1430728	Metabolism
R-HSA-1855204	Synthesis of IP3 and IP4 in the cytosol	Leaf	R-HSA-1430728	Metabolism
R-HSA-983231	Factors involved in megakaryocyte development and platelet production	Internal node	R-HSA-109582	Hemostasis

Tissue	Cell type	Expression level	Reliability
appendix	glandular cells	Low	Approved
bronchus	ciliated cells (ciliary rootlets)	Low	Approved
cerebellum	cells in granular layer	Medium	Approved
cerebral cortex	neuronal cells	Low	Approved
cerebral cortex	neuropil	Low	Approved
cervix	squamous epithelial cells	Low	Approved
colon	glandular cells	Low	Approved
duodenum	glandular cells	Medium	Approved
endometrium 2	glandular cells	Low	Approved
epididymis	glandular cells	Medium	Approved
esophagus	squamous epithelial cells	Low	Approved
fallopian tube	ciliated cells (ciliary rootlets)	Medium	Approved
gallbladder	glandular cells	Medium	Approved
heart muscle	cardiomyocytes	Medium	Approved
hippocampus	neuronal cells	Low	Approved
kidney	cells in tubules	Medium	Approved
nasopharynx	ciliated cells (ciliary rootlets)	High	Approved
oral mucosa	squamous epithelial cells	Low	Approved
pancreas	exocrine glandular cells	Low	Approved
rectum	glandular cells	Medium	Approved
salivary gland	glandular cells	Low	Approved
skin 2	epidermal cells	Low	Approved
small intestine	glandular cells	Medium	Approved
stomach 1	glandular cells	Medium	Approved
stomach 2	glandular cells	Medium	Approved
testis	Leydig cells	Low	Approved
thyroid gland	glandular cells	Medium	Approved
vagina	squamous epithelial cells	Low	Approved